Identification of Ten Long Noncoding RNAs as Biomarkers for Hepatocellular Carcinoma
Abstract Long-chain non-encoded RNAs (lncRNAs) are important in many life activities and can participate in the occurrence of hepatocellular carcinoma (HCC). Moreover, lncRNAs can be used as basis for developing new strategies to hinder liver cancer. To investigate the utility of lncRNAs in HCC as p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto de Tecnologia do Paraná (Tecpar)
2020-10-01
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| Series: | Brazilian Archives of Biology and Technology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100325&tlng=en |
| _version_ | 1818978035693518848 |
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| author | Chao Lin Dan Zhang Xiaoxiao Yao Shui Liu Yien Xiang Xuewen Zhang |
| author_facet | Chao Lin Dan Zhang Xiaoxiao Yao Shui Liu Yien Xiang Xuewen Zhang |
| author_sort | Chao Lin |
| collection | DOAJ |
| description | Abstract Long-chain non-encoded RNAs (lncRNAs) are important in many life activities and can participate in the occurrence of hepatocellular carcinoma (HCC). Moreover, lncRNAs can be used as basis for developing new strategies to hinder liver cancer. To investigate the utility of lncRNAs in HCC as potential biomarkers for early detection and diagnosis, we mined genomic data from the Cancer Genome Atlas (TCGA), and analyzed the gene expressions from 374 tumor patients and 50 normal patients. The abnormal expressions of 387 differentially expressed lncRNAs (DElncRNAs) were identified from a total of 3099 lncRNAs. Moreover, 18 modules were divided based on WGCNA, and 2 of the 18 modules were positively correlated with stage and grade, and negatively correlated with survival time. Finally, 10 lncRNAs were found and their main functions are the enhancement of cellular metabolic capacity and cell proliferation. These 10 lncRNAs may serve as novel prognostic markers and therapeutic targets, and may help guide subsequent studies on HCC. |
| first_indexed | 2024-12-20T16:37:14Z |
| format | Article |
| id | doaj.art-6994ea88a89c470481d2b8ab545052c4 |
| institution | Directory Open Access Journal |
| issn | 1678-4324 |
| language | English |
| last_indexed | 2024-12-20T16:37:14Z |
| publishDate | 2020-10-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-6994ea88a89c470481d2b8ab545052c42022-12-21T19:33:07ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242020-10-016310.1590/1678-4324-2020190511Identification of Ten Long Noncoding RNAs as Biomarkers for Hepatocellular CarcinomaChao Linhttps://orcid.org/0000-0002-7658-9136Dan Zhanghttps://orcid.org/0000-0002-7363-4157Xiaoxiao Yaohttps://orcid.org/0000-0002-1045-8627Shui Liuhttps://orcid.org/0000-0002-6379-9230Yien Xianghttps://orcid.org/0000-0001-7994-1302Xuewen Zhanghttps://orcid.org/0000-0002-3619-2222Abstract Long-chain non-encoded RNAs (lncRNAs) are important in many life activities and can participate in the occurrence of hepatocellular carcinoma (HCC). Moreover, lncRNAs can be used as basis for developing new strategies to hinder liver cancer. To investigate the utility of lncRNAs in HCC as potential biomarkers for early detection and diagnosis, we mined genomic data from the Cancer Genome Atlas (TCGA), and analyzed the gene expressions from 374 tumor patients and 50 normal patients. The abnormal expressions of 387 differentially expressed lncRNAs (DElncRNAs) were identified from a total of 3099 lncRNAs. Moreover, 18 modules were divided based on WGCNA, and 2 of the 18 modules were positively correlated with stage and grade, and negatively correlated with survival time. Finally, 10 lncRNAs were found and their main functions are the enhancement of cellular metabolic capacity and cell proliferation. These 10 lncRNAs may serve as novel prognostic markers and therapeutic targets, and may help guide subsequent studies on HCC.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100325&tlng=enlong noncoding RNAshepatocellular carcinomabiomarkers |
| spellingShingle | Chao Lin Dan Zhang Xiaoxiao Yao Shui Liu Yien Xiang Xuewen Zhang Identification of Ten Long Noncoding RNAs as Biomarkers for Hepatocellular Carcinoma Brazilian Archives of Biology and Technology long noncoding RNAs hepatocellular carcinoma biomarkers |
| title | Identification of Ten Long Noncoding RNAs as Biomarkers for Hepatocellular Carcinoma |
| title_full | Identification of Ten Long Noncoding RNAs as Biomarkers for Hepatocellular Carcinoma |
| title_fullStr | Identification of Ten Long Noncoding RNAs as Biomarkers for Hepatocellular Carcinoma |
| title_full_unstemmed | Identification of Ten Long Noncoding RNAs as Biomarkers for Hepatocellular Carcinoma |
| title_short | Identification of Ten Long Noncoding RNAs as Biomarkers for Hepatocellular Carcinoma |
| title_sort | identification of ten long noncoding rnas as biomarkers for hepatocellular carcinoma |
| topic | long noncoding RNAs hepatocellular carcinoma biomarkers |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100325&tlng=en |
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