Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks
The Wnt pathway is an integral cell-to-cell signaling hub which regulates crucial development processes and maintenance of tissue homeostasis by coordinating cell proliferation, differentiation, cell polarity, cell movement, and stem cell renewal. When dysregulated, it is associated with various dev...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/21/8018 |
| _version_ | 1797549597156966400 |
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| author | Monica Sharma Kevin Pruitt |
| author_facet | Monica Sharma Kevin Pruitt |
| author_sort | Monica Sharma |
| collection | DOAJ |
| description | The Wnt pathway is an integral cell-to-cell signaling hub which regulates crucial development processes and maintenance of tissue homeostasis by coordinating cell proliferation, differentiation, cell polarity, cell movement, and stem cell renewal. When dysregulated, it is associated with various developmental diseases, fibrosis, and tumorigenesis. We now better appreciate the complexity and crosstalk of the Wnt pathway with other signaling cascades. Emerging roles of the Wnt signaling in the cancer stem cell niche and drug resistance have led to development of therapeutics specifically targeting various Wnt components, with some agents currently in clinical trials. This review highlights historical and recent findings on key mediators of Wnt signaling and how they impact antitumor immunity and maintenance of cancer stem cells. This review also examines current therapeutics being developed that modulate Wnt signaling in cancer and discusses potential shortcomings associated with available therapeutics. |
| first_indexed | 2024-03-10T15:16:52Z |
| format | Article |
| id | doaj.art-699a2894d6dd4b4981db11f23f00c1bf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:16:52Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-699a2894d6dd4b4981db11f23f00c1bf2023-11-20T18:50:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012121801810.3390/ijms21218018Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling NetworksMonica Sharma0Kevin Pruitt1Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USADepartment of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USAThe Wnt pathway is an integral cell-to-cell signaling hub which regulates crucial development processes and maintenance of tissue homeostasis by coordinating cell proliferation, differentiation, cell polarity, cell movement, and stem cell renewal. When dysregulated, it is associated with various developmental diseases, fibrosis, and tumorigenesis. We now better appreciate the complexity and crosstalk of the Wnt pathway with other signaling cascades. Emerging roles of the Wnt signaling in the cancer stem cell niche and drug resistance have led to development of therapeutics specifically targeting various Wnt components, with some agents currently in clinical trials. This review highlights historical and recent findings on key mediators of Wnt signaling and how they impact antitumor immunity and maintenance of cancer stem cells. This review also examines current therapeutics being developed that modulate Wnt signaling in cancer and discusses potential shortcomings associated with available therapeutics.https://www.mdpi.com/1422-0067/21/21/8018Wnt signalinghuman diseasescancerantitumor immunitycancer stemnesstherapeutic strategies |
| spellingShingle | Monica Sharma Kevin Pruitt Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks International Journal of Molecular Sciences Wnt signaling human diseases cancer antitumor immunity cancer stemness therapeutic strategies |
| title | Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks |
| title_full | Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks |
| title_fullStr | Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks |
| title_full_unstemmed | Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks |
| title_short | Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks |
| title_sort | wnt pathway an integral hub for developmental and oncogenic signaling networks |
| topic | Wnt signaling human diseases cancer antitumor immunity cancer stemness therapeutic strategies |
| url | https://www.mdpi.com/1422-0067/21/21/8018 |
| work_keys_str_mv | AT monicasharma wntpathwayanintegralhubfordevelopmentalandoncogenicsignalingnetworks AT kevinpruitt wntpathwayanintegralhubfordevelopmentalandoncogenicsignalingnetworks |