Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology
The dogma that thyroid-stimulating hormone (TSH) solely regulates the production of thyroid hormone from the thyroid gland has hampered research on its wider physiological roles. The action of pituitary TSH on the skeleton has now been well described; in particular, its action on osteoblasts and ost...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2017.00252/full |
| _version_ | 1818596192379994112 |
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| author | Ramkumarie Baliram Rauf Latif Mone Zaidi Terry F. Davies Terry F. Davies |
| author_facet | Ramkumarie Baliram Rauf Latif Mone Zaidi Terry F. Davies Terry F. Davies |
| author_sort | Ramkumarie Baliram |
| collection | DOAJ |
| description | The dogma that thyroid-stimulating hormone (TSH) solely regulates the production of thyroid hormone from the thyroid gland has hampered research on its wider physiological roles. The action of pituitary TSH on the skeleton has now been well described; in particular, its action on osteoblasts and osteoclasts. It has also been recently discovered that the bone marrow microenvironment acts as an endocrine circuit with bone marrow-resident macrophages capable of producing a novel TSH-β subunit variant (TSH-βv), which may modulate skeletal physiology. Interestingly, the production of this TSH-βv is positively regulated by T3 accentuating such modulation in the presence of thyroid overactivity. Furthermore, a number of small molecule ligands acting as TSH agonists, which allosterically modulate the TSH receptor have been identified and may have similar modulatory influences on bone cells suggesting therapeutic potential. This review summarizes our current understanding of the role of TSH, TSH-β, TSH-βv, and small molecule agonists in bone physiology. |
| first_indexed | 2024-12-16T11:28:00Z |
| format | Article |
| id | doaj.art-699aacf1739648cebfe1ef1fb75ead8f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-16T11:28:00Z |
| publishDate | 2017-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-699aacf1739648cebfe1ef1fb75ead8f2022-12-21T22:33:19ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922017-10-01810.3389/fendo.2017.00252289602Expanding the Role of Thyroid-Stimulating Hormone in Skeletal PhysiologyRamkumarie Baliram0Rauf Latif1Mone Zaidi2Terry F. Davies3Terry F. Davies4Thyroid Research Unit, Icahn School of Medicine at Mount Sinai and the James J. Peters VA Medical Center, New York, NY, United StatesThyroid Research Unit, Icahn School of Medicine at Mount Sinai and the James J. Peters VA Medical Center, New York, NY, United StatesThe Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesThyroid Research Unit, Icahn School of Medicine at Mount Sinai and the James J. Peters VA Medical Center, New York, NY, United StatesThe Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesThe dogma that thyroid-stimulating hormone (TSH) solely regulates the production of thyroid hormone from the thyroid gland has hampered research on its wider physiological roles. The action of pituitary TSH on the skeleton has now been well described; in particular, its action on osteoblasts and osteoclasts. It has also been recently discovered that the bone marrow microenvironment acts as an endocrine circuit with bone marrow-resident macrophages capable of producing a novel TSH-β subunit variant (TSH-βv), which may modulate skeletal physiology. Interestingly, the production of this TSH-βv is positively regulated by T3 accentuating such modulation in the presence of thyroid overactivity. Furthermore, a number of small molecule ligands acting as TSH agonists, which allosterically modulate the TSH receptor have been identified and may have similar modulatory influences on bone cells suggesting therapeutic potential. This review summarizes our current understanding of the role of TSH, TSH-β, TSH-βv, and small molecule agonists in bone physiology.http://journal.frontiersin.org/article/10.3389/fendo.2017.00252/fullTSH-βTSH-βvTSH-receptormacrophageosteoblastosteoclast |
| spellingShingle | Ramkumarie Baliram Rauf Latif Mone Zaidi Terry F. Davies Terry F. Davies Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology Frontiers in Endocrinology TSH-β TSH-βv TSH-receptor macrophage osteoblast osteoclast |
| title | Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology |
| title_full | Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology |
| title_fullStr | Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology |
| title_full_unstemmed | Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology |
| title_short | Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology |
| title_sort | expanding the role of thyroid stimulating hormone in skeletal physiology |
| topic | TSH-β TSH-βv TSH-receptor macrophage osteoblast osteoclast |
| url | http://journal.frontiersin.org/article/10.3389/fendo.2017.00252/full |
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