Peculiarities of Atypical Meningiomas: Literature Review
Introduction Meningiomas are common tumors of the central nervous system that represent around 30% of primary tumors. However, the incidence of atypical meningiomas (AMs) is lower, of approximately 15% of all meningiomas, and they present high rates of relapse and mortality. Aim To review...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2022-06-01
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| Series: | Brazilian Neurosurgery |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1742427 |
| _version_ | 1811326200919883776 |
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| author | Rafael Rodrigues Pinheiro dos Santos Ana Carla Mondek Rampazzo Carlos Alexandre Martins Zicarelli Leonardo Valente de Camargo |
| author_facet | Rafael Rodrigues Pinheiro dos Santos Ana Carla Mondek Rampazzo Carlos Alexandre Martins Zicarelli Leonardo Valente de Camargo |
| author_sort | Rafael Rodrigues Pinheiro dos Santos |
| collection | DOAJ |
| description | Introduction Meningiomas are common tumors of the central nervous system that represent around 30% of primary tumors. However, the incidence of atypical meningiomas (AMs) is lower, of approximately 15% of all meningiomas, and they present high rates of relapse and mortality.
Aim To review peculiarities of AMs.
Methodology A literature review of articles published in English between 2009 and 2020 on the PubMed and Biblioteca Virtual em Saúde (BVS) databases using the terms meningioma and atypical.
Results Atypical meningiomas are rare and more prevalent in older males. The clinical condition depends on the site of the tumor, and a definitive diagnosis of AM is only possible via anatomical pathology. Moreover, prominent studies have indicated a relationship between the presence of the anti-Ki67 antibody/mindbomb (Ki-67/MIB1) marker as an aid in the definition of AM and one of the determinants of tumor aggressiveness. Imaging studies have also advanced in terms of seeking criteria using magnetic resonance that may suggest the malignancy of a lesion. As far as treatment is concerned, total resection remains the main therapeutic option, and it has a direct relationship with survival and time until disease progression. Lastly, there are many factors involved in the prognosis of AM.
Conclusion Atypical meningiomas continue to be a challenge, requiring further and more specific studies to provide a better understanding of it. |
| first_indexed | 2024-04-13T14:46:00Z |
| format | Article |
| id | doaj.art-699c3b62ff6f49e6b41152c5e328edd1 |
| institution | Directory Open Access Journal |
| issn | 0103-5355 2359-5922 |
| language | English |
| last_indexed | 2024-04-13T14:46:00Z |
| publishDate | 2022-06-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Brazilian Neurosurgery |
| spelling | doaj.art-699c3b62ff6f49e6b41152c5e328edd12022-12-22T02:42:45ZengThieme Revinter Publicações Ltda.Brazilian Neurosurgery0103-53552359-59222022-06-014102e137e14410.1055/s-0042-1742427Peculiarities of Atypical Meningiomas: Literature ReviewRafael Rodrigues Pinheiro dos Santos0Ana Carla Mondek Rampazzo1Carlos Alexandre Martins Zicarelli2Leonardo Valente de Camargo3Department of Neuroscience, Pontifícia Universidade Católica do Paraná, Londrina, Paraná, BrazilDepartment of Neuroscience, Pontifícia Universidade Católica do Paraná, Londrina, Paraná, BrazilDepartment of Neurosurgery, Hospital Evangélico de Londrina, Londrina, Paraná, BrazilNeurology Residency Program, Hospital Evangélico de Londrina Londrina, BrazilIntroduction Meningiomas are common tumors of the central nervous system that represent around 30% of primary tumors. However, the incidence of atypical meningiomas (AMs) is lower, of approximately 15% of all meningiomas, and they present high rates of relapse and mortality. Aim To review peculiarities of AMs. Methodology A literature review of articles published in English between 2009 and 2020 on the PubMed and Biblioteca Virtual em Saúde (BVS) databases using the terms meningioma and atypical. Results Atypical meningiomas are rare and more prevalent in older males. The clinical condition depends on the site of the tumor, and a definitive diagnosis of AM is only possible via anatomical pathology. Moreover, prominent studies have indicated a relationship between the presence of the anti-Ki67 antibody/mindbomb (Ki-67/MIB1) marker as an aid in the definition of AM and one of the determinants of tumor aggressiveness. Imaging studies have also advanced in terms of seeking criteria using magnetic resonance that may suggest the malignancy of a lesion. As far as treatment is concerned, total resection remains the main therapeutic option, and it has a direct relationship with survival and time until disease progression. Lastly, there are many factors involved in the prognosis of AM. Conclusion Atypical meningiomas continue to be a challenge, requiring further and more specific studies to provide a better understanding of it.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1742427meningiomamalign meningiomaimmunohistochemistryprognosis |
| spellingShingle | Rafael Rodrigues Pinheiro dos Santos Ana Carla Mondek Rampazzo Carlos Alexandre Martins Zicarelli Leonardo Valente de Camargo Peculiarities of Atypical Meningiomas: Literature Review Brazilian Neurosurgery meningioma malign meningioma immunohistochemistry prognosis |
| title | Peculiarities of Atypical Meningiomas: Literature Review |
| title_full | Peculiarities of Atypical Meningiomas: Literature Review |
| title_fullStr | Peculiarities of Atypical Meningiomas: Literature Review |
| title_full_unstemmed | Peculiarities of Atypical Meningiomas: Literature Review |
| title_short | Peculiarities of Atypical Meningiomas: Literature Review |
| title_sort | peculiarities of atypical meningiomas literature review |
| topic | meningioma malign meningioma immunohistochemistry prognosis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1742427 |
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