Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst
CDC7 is a serine/threonine kinase which has an essential role in initiation of DNA proliferation and S phase. It increases the invasion and proliferation in many pathologic lesions. This study aimed to evaluate the expression of CDC7 in the most common odontogenic cysts. We evaluated 17 dentigerous...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karolinum Press
2018-07-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/61/1/0017/ |
| _version_ | 1811260040978366464 |
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| author | Zohreh Jaafari-Ashkavandi Ahmad Alipour Tuyeh Sepideh Assar |
| author_facet | Zohreh Jaafari-Ashkavandi Ahmad Alipour Tuyeh Sepideh Assar |
| author_sort | Zohreh Jaafari-Ashkavandi |
| collection | DOAJ |
| description | CDC7 is a serine/threonine kinase which has an essential role in initiation of DNA proliferation and S phase. It increases the invasion and proliferation in many pathologic lesions. This study aimed to evaluate the expression of CDC7 in the most common odontogenic cysts. We evaluated 17 dentigerous cysts, 18 odontogenic keratocysts (OKC) and 13 radicular cysts immunohistochemically. The mean expression of CDC7 was analyzed using ANOVA and Post-HOC methods. All specimens revealed CDC7 expression. Higher expression of CDC7 in OKC and radicular cyst was shown in comparison to dentigerous cyst (P < 0.001), while radicular cyst and OKC groups showed no difference in CDC7 expression (P = 0.738). The high expression of CDC7 in OKC suggests that this protein could be related to the higher proliferation rate and invasiveness of OKC. On the other hand, the higher CDC7 expression in radicular cyst may simply be related to inflammation as this cyst is neither aggressive nor invasive. |
| first_indexed | 2024-04-12T18:40:36Z |
| format | Article |
| id | doaj.art-699ce7cc7f8047758dbba4dc491345b2 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-04-12T18:40:36Z |
| publishDate | 2018-07-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-699ce7cc7f8047758dbba4dc491345b22022-12-22T03:20:47ZengKarolinum PressActa Medica1211-42861805-96942018-07-01611172110.14712/18059694.2018.187043Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular CystZohreh Jaafari-AshkavandiAhmad Alipour TuyehSepideh AssarCDC7 is a serine/threonine kinase which has an essential role in initiation of DNA proliferation and S phase. It increases the invasion and proliferation in many pathologic lesions. This study aimed to evaluate the expression of CDC7 in the most common odontogenic cysts. We evaluated 17 dentigerous cysts, 18 odontogenic keratocysts (OKC) and 13 radicular cysts immunohistochemically. The mean expression of CDC7 was analyzed using ANOVA and Post-HOC methods. All specimens revealed CDC7 expression. Higher expression of CDC7 in OKC and radicular cyst was shown in comparison to dentigerous cyst (P < 0.001), while radicular cyst and OKC groups showed no difference in CDC7 expression (P = 0.738). The high expression of CDC7 in OKC suggests that this protein could be related to the higher proliferation rate and invasiveness of OKC. On the other hand, the higher CDC7 expression in radicular cyst may simply be related to inflammation as this cyst is neither aggressive nor invasive.https://actamedica.lfhk.cuni.cz/61/1/0017/CDC7dentigerous cystodontogenic keratocystradicular cystimmunohistochemistry |
| spellingShingle | Zohreh Jaafari-Ashkavandi Ahmad Alipour Tuyeh Sepideh Assar Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst Acta Medica CDC7 dentigerous cyst odontogenic keratocyst radicular cyst immunohistochemistry |
| title | Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst |
| title_full | Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst |
| title_fullStr | Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst |
| title_full_unstemmed | Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst |
| title_short | Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst |
| title_sort | immunohistochemical expression of cdc7 in dentigerous cyst odontogenic keratocyst and radicular cyst |
| topic | CDC7 dentigerous cyst odontogenic keratocyst radicular cyst immunohistochemistry |
| url | https://actamedica.lfhk.cuni.cz/61/1/0017/ |
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