The FABD domain is critical for the oncogenicity of BCR/ABL in chronic myeloid leukaemia

The FABD domain is critical for the oncogenicity of BCR/ABL in chronic myeloid leukaemia

Abstract Background Abnormally expressed BCR/ABL protein serves as the basis for the development of chronic myeloid leukaemia (CML). The F-actin binding domain (FABD), which is a crucial region of the BCR/ABL fusion protein, is also located at the carboxyl end of the c-ABL protein and regulates the...

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Bibliographic Details
Main Authors: Renren Zheng, Wei Wei, Suotian Liu, Dachuan Zeng, Zesong Yang, Jie Tang, Jinfeng Tan, Zhenglan Huang, Miao Gao
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Cell Communication and Signaling
Subjects:
F-actin binding domain
BCR/ABL
Chronic myeloid leukaemia
Oncogenicity
p73
Online Access:https://doi.org/10.1186/s12964-024-01694-8

Internet

https://doi.org/10.1186/s12964-024-01694-8

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