Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies

Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies

Abstract There is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. A major barrier to developing useful markers for this is biological heterogeneity, where many different pathological mechanisms may underly the same set...

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Bibliographic Details
Main Authors: Amanda Worker, Pierre Berthert, Andrew J. Lawrence, Seyed Mostafa Kia, Celso Arango, Richard Dinga, Silvana Galderisi, Birte Glenthøj, René S. Kahn, Anoushka Leslie, Robin M. Murray, Carmine M. Pariante, Christos Pantelis, Mark Weiser, Inge Winter-van Rossum, Philip McGuire, Paola Dazzan, Andre F. Marquand
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02661-6

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