Polymorphisms in the Promoter Region of the Chinese Bovine Gene
The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis. The genetic variations within the PPARGC1A gene promoter region were scanned in 808 Chinese native bovines belonging to three cattle breeds a...
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| Format: | Article |
| Language: | English |
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Asian-Australasian Association of Animal Production Societies
2013-04-01
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| Series: | Asian-Australasian Journal of Animal Sciences |
| Subjects: | |
| Online Access: | http://www.ajas.info/upload/pdf/ajas-26-4-483-5.pdf |
| _version_ | 1818929337820250112 |
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| author | M. J. Li M. Liu D. Liu X. Y. Lan C. Z. Lei D. Y. Yang H. Chen |
| author_facet | M. J. Li M. Liu D. Liu X. Y. Lan C. Z. Lei D. Y. Yang H. Chen |
| author_sort | M. J. Li |
| collection | DOAJ |
| description | The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis. The genetic variations within the PPARGC1A gene promoter region were scanned in 808 Chinese native bovines belonging to three cattle breeds and yaks. A total of 6 SNPs and one 4 bp insertion variation in the promoter region of the bovine PPARGC1A gene were identified: SNP -259 T>A, -301_-298insCTTT, -915 A>G, -1175 T>G, -1590 C>T, -1665 C>T and -1690 G>A, which are in the binding sites of some important transcription factors: sex-determining region Y (SRY), myeloid-specific zinc finger-1 (MZF-1) and octamer factor 1(Oct-1). It is expected that these polymorphisms may regulate PPARGC1A gene transcription and might have consequences at a regulatory level. |
| first_indexed | 2024-12-20T03:43:12Z |
| format | Article |
| id | doaj.art-69a8fb3da2f042b8be539e11d74183d2 |
| institution | Directory Open Access Journal |
| issn | 1011-2367 1976-5517 |
| language | English |
| last_indexed | 2024-12-20T03:43:12Z |
| publishDate | 2013-04-01 |
| publisher | Asian-Australasian Association of Animal Production Societies |
| record_format | Article |
| series | Asian-Australasian Journal of Animal Sciences |
| spelling | doaj.art-69a8fb3da2f042b8be539e11d74183d22022-12-21T19:54:41ZengAsian-Australasian Association of Animal Production SocietiesAsian-Australasian Journal of Animal Sciences1011-23671976-55172013-04-0126448348710.5713/ajas.2012.125544672Polymorphisms in the Promoter Region of the Chinese Bovine GeneM. J. LiM. LiuD. LiuX. Y. LanC. Z. LeiD. Y. YangH. ChenThe peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis. The genetic variations within the PPARGC1A gene promoter region were scanned in 808 Chinese native bovines belonging to three cattle breeds and yaks. A total of 6 SNPs and one 4 bp insertion variation in the promoter region of the bovine PPARGC1A gene were identified: SNP -259 T>A, -301_-298insCTTT, -915 A>G, -1175 T>G, -1590 C>T, -1665 C>T and -1690 G>A, which are in the binding sites of some important transcription factors: sex-determining region Y (SRY), myeloid-specific zinc finger-1 (MZF-1) and octamer factor 1(Oct-1). It is expected that these polymorphisms may regulate PPARGC1A gene transcription and might have consequences at a regulatory level.http://www.ajas.info/upload/pdf/ajas-26-4-483-5.pdfBovine GenePromoter RegionPolymorphisms |
| spellingShingle | M. J. Li M. Liu D. Liu X. Y. Lan C. Z. Lei D. Y. Yang H. Chen Polymorphisms in the Promoter Region of the Chinese Bovine Gene Asian-Australasian Journal of Animal Sciences Bovine Gene Promoter Region Polymorphisms |
| title | Polymorphisms in the Promoter Region of the Chinese Bovine Gene |
| title_full | Polymorphisms in the Promoter Region of the Chinese Bovine Gene |
| title_fullStr | Polymorphisms in the Promoter Region of the Chinese Bovine Gene |
| title_full_unstemmed | Polymorphisms in the Promoter Region of the Chinese Bovine Gene |
| title_short | Polymorphisms in the Promoter Region of the Chinese Bovine Gene |
| title_sort | polymorphisms in the promoter region of the chinese bovine gene |
| topic | Bovine Gene Promoter Region Polymorphisms |
| url | http://www.ajas.info/upload/pdf/ajas-26-4-483-5.pdf |
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