Clinical profiles of patients with wheat-induced anaphylaxis at various ages of onset
Background: Wheat-induced anaphylaxis (WIA) is a serious and potentially life-threatening wheat allergy, more common in adults than in children. Little is known about the differences in clinical profiles in WIA among patients of various ages in China. Methods: We analyzed data retrospectively from a...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | World Allergy Organization Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455123000273 |
| _version_ | 1797831056999579648 |
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| author | Zhirong Du, PhD Lun Li, MD Juan Liu, PhD Yingyang Xu, PhD Le Cui, PhD Jia Yin, MS |
| author_facet | Zhirong Du, PhD Lun Li, MD Juan Liu, PhD Yingyang Xu, PhD Le Cui, PhD Jia Yin, MS |
| author_sort | Zhirong Du, PhD |
| collection | DOAJ |
| description | Background: Wheat-induced anaphylaxis (WIA) is a serious and potentially life-threatening wheat allergy, more common in adults than in children. Little is known about the differences in clinical profiles in WIA among patients of various ages in China. Methods: We analyzed data retrospectively from an allergy department in a tertiary hospital that included 248 patients (208 adults and 40 children and adolescents) with a history of WIA. Results: We found that alcohol was more frequent in patients aged ≥50 years [older adults] (19.0%, 4/21) than in those aged 12–17 years [adolescents] (0%, 0/33; p = 0.019). The frequency of NSAID use in older adults (42.9%, 9/21) was significantly higher than that in adolescents (0%, 0/33; p < 0.001), and patients aged 18–49 years [young adults] (2.8%, 5/178; p < 0.001). During WIA, cardiovascular symptoms in children were less frequent than those in other age groups (children, 28.6%; adolescents, 87.9%; young adults, 93.0%; older adults, 95.2%; p < 0.001). The consciousness loss rate in adults (both age groups; p < 0.001) and the hypotension rate in older adults (p = 0.006) were higher than those in other age groups. Compared with adults (young and older adults), children had a higher rate of allergic comorbidities (p = 0.004, 0.001, respectively) and a higher rate of other food allergies (p < 0.001, <0.001, respectively). Compared with the mild-to-moderate anaphylaxis group, the severe anaphylaxis group had a higher onset age (p = 0.001), higher cofactor prevalence (p = 0.004), lower allergic comorbidity rate (p = 0.014), and higher positive rate of specific IgE to omega-5 gliadin (ω-5 gliadin) (p = 0.023). Conclusion: Clinical profiles of patients with WIA are different among various onset age/severity groups. An improved understanding of WIA symptoms in various age/severity groups could help accelerate diagnosis, suggest preventive measures, and contribute to improved patient care. |
| first_indexed | 2024-04-09T13:45:56Z |
| format | Article |
| id | doaj.art-69a9b9c2cee24bf1bbf620d2f1d8d1fc |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-04-09T13:45:56Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-69a9b9c2cee24bf1bbf620d2f1d8d1fc2023-05-09T04:05:04ZengElsevierWorld Allergy Organization Journal1939-45512023-04-01164100767Clinical profiles of patients with wheat-induced anaphylaxis at various ages of onsetZhirong Du, PhD0Lun Li, MD1Juan Liu, PhD2Yingyang Xu, PhD3Le Cui, PhD4Jia Yin, MS5Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, Beijing, 100730, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, ChinaDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, Beijing, 100730, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, ChinaDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, Beijing, 100730, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, ChinaDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, Beijing, 100730, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, ChinaDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, Beijing, 100730, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, ChinaDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, Beijing, 100730, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China; Corresponding author. Department of Allergy, Peking Union Medical College Hospital, No. 1 Shuaifuyuan Street, Wangfujing, Beijing, 100730, China.Background: Wheat-induced anaphylaxis (WIA) is a serious and potentially life-threatening wheat allergy, more common in adults than in children. Little is known about the differences in clinical profiles in WIA among patients of various ages in China. Methods: We analyzed data retrospectively from an allergy department in a tertiary hospital that included 248 patients (208 adults and 40 children and adolescents) with a history of WIA. Results: We found that alcohol was more frequent in patients aged ≥50 years [older adults] (19.0%, 4/21) than in those aged 12–17 years [adolescents] (0%, 0/33; p = 0.019). The frequency of NSAID use in older adults (42.9%, 9/21) was significantly higher than that in adolescents (0%, 0/33; p < 0.001), and patients aged 18–49 years [young adults] (2.8%, 5/178; p < 0.001). During WIA, cardiovascular symptoms in children were less frequent than those in other age groups (children, 28.6%; adolescents, 87.9%; young adults, 93.0%; older adults, 95.2%; p < 0.001). The consciousness loss rate in adults (both age groups; p < 0.001) and the hypotension rate in older adults (p = 0.006) were higher than those in other age groups. Compared with adults (young and older adults), children had a higher rate of allergic comorbidities (p = 0.004, 0.001, respectively) and a higher rate of other food allergies (p < 0.001, <0.001, respectively). Compared with the mild-to-moderate anaphylaxis group, the severe anaphylaxis group had a higher onset age (p = 0.001), higher cofactor prevalence (p = 0.004), lower allergic comorbidity rate (p = 0.014), and higher positive rate of specific IgE to omega-5 gliadin (ω-5 gliadin) (p = 0.023). Conclusion: Clinical profiles of patients with WIA are different among various onset age/severity groups. An improved understanding of WIA symptoms in various age/severity groups could help accelerate diagnosis, suggest preventive measures, and contribute to improved patient care.http://www.sciencedirect.com/science/article/pii/S1939455123000273AnaphylaxisWheat allergyWheat-induced anaphylaxisWheat-dependent exercise-induced anaphylaxisOmega-5 gliadin |
| spellingShingle | Zhirong Du, PhD Lun Li, MD Juan Liu, PhD Yingyang Xu, PhD Le Cui, PhD Jia Yin, MS Clinical profiles of patients with wheat-induced anaphylaxis at various ages of onset World Allergy Organization Journal Anaphylaxis Wheat allergy Wheat-induced anaphylaxis Wheat-dependent exercise-induced anaphylaxis Omega-5 gliadin |
| title | Clinical profiles of patients with wheat-induced anaphylaxis at various ages of onset |
| title_full | Clinical profiles of patients with wheat-induced anaphylaxis at various ages of onset |
| title_fullStr | Clinical profiles of patients with wheat-induced anaphylaxis at various ages of onset |
| title_full_unstemmed | Clinical profiles of patients with wheat-induced anaphylaxis at various ages of onset |
| title_short | Clinical profiles of patients with wheat-induced anaphylaxis at various ages of onset |
| title_sort | clinical profiles of patients with wheat induced anaphylaxis at various ages of onset |
| topic | Anaphylaxis Wheat allergy Wheat-induced anaphylaxis Wheat-dependent exercise-induced anaphylaxis Omega-5 gliadin |
| url | http://www.sciencedirect.com/science/article/pii/S1939455123000273 |
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