The Frequency of Natural Killer Cell Subsets in Patients with Acquired Immune Deficiency Syndrome with Deep Fungal Infections
Gao Chen, Chun-Jun Qin, Meng-Zheng Wu, Fei-Fei Liu, Shu-Shu Liu, Li Liu Department of Infectious Diseases, People’s Hospital of Deyang City, Deyang, 618000, People’s Republic of ChinaCorrespondence: Gao ChenDepartment of Infectious Diseases, People’s Hospital of Deyang...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-02-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-frequency-of-natural-killer-cell-subsets-in-patients-with-acquired-peer-reviewed-article-IDR |
| _version_ | 1819178187537514496 |
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| author | Chen G Qin CJ Wu MZ Liu FF Liu SS Liu L |
| author_facet | Chen G Qin CJ Wu MZ Liu FF Liu SS Liu L |
| author_sort | Chen G |
| collection | DOAJ |
| description | Gao Chen, Chun-Jun Qin, Meng-Zheng Wu, Fei-Fei Liu, Shu-Shu Liu, Li Liu Department of Infectious Diseases, People’s Hospital of Deyang City, Deyang, 618000, People’s Republic of ChinaCorrespondence: Gao ChenDepartment of Infectious Diseases, People’s Hospital of Deyang City, No. 173 of Sec. 1, Taishan North Road, Jingyang District, Deyang, 618000, People’s Republic of ChinaTel/Fax +86 8382418631Email chenchen99_dr@163.comObjective: This study aimed to investigate the expression of natural killer (NK) cell subsets in patients with acquired immune deficiency syndrome (AIDS) and deep fungal infections and the significance of such expression.Methods: A total of 829 patients with AIDS, who were treated in People’s Hospital of Deyang City our hospital between January 2011 and March 2019, were enrolled in the study. They were divided into two groups: those with human immunodeficiency virus (HIV) and invasive fungal infection (IFI) (HIV + IFI) (n = 390) and those with HIV and no IFI (HIV + non-IFI) (n = 439). Another 200 healthy volunteers were enrolled as the control group. The numbers of NK cell subsets in each group were compared.Results: The level of NK cells, number of NK cells in all lymphocytes, proportions of CD56bright, CD56dim, and CD56dim NK cells in NK cells, and the level of CD56–CD16+ NK cells were significantly lower in the HIV + IFI group than in the HIV + non-IFI group and control group (P < 0.05). Moreover, CD4+ T, CD4+/CD8+, and NK cells were negatively correlated with HIV-RNA expression (P < 0.05).Conclusion: A combination of AIDS and deep fungal infection can change the immune status of a patient. This condition can be diagnosed early through the detection of NK cell expression.Keywords: natural killer cells, AIDS, deep fungal infection, CD56, expression |
| first_indexed | 2024-12-22T21:38:34Z |
| format | Article |
| id | doaj.art-69abe2e3b4b84db9b755ef4492c17edf |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-22T21:38:34Z |
| publishDate | 2021-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-69abe2e3b4b84db9b755ef4492c17edf2022-12-21T18:11:41ZengDove Medical PressInfection and Drug Resistance1178-69732021-02-01Volume 1446747361866The Frequency of Natural Killer Cell Subsets in Patients with Acquired Immune Deficiency Syndrome with Deep Fungal InfectionsChen GQin CJWu MZLiu FFLiu SSLiu LGao Chen, Chun-Jun Qin, Meng-Zheng Wu, Fei-Fei Liu, Shu-Shu Liu, Li Liu Department of Infectious Diseases, People’s Hospital of Deyang City, Deyang, 618000, People’s Republic of ChinaCorrespondence: Gao ChenDepartment of Infectious Diseases, People’s Hospital of Deyang City, No. 173 of Sec. 1, Taishan North Road, Jingyang District, Deyang, 618000, People’s Republic of ChinaTel/Fax +86 8382418631Email chenchen99_dr@163.comObjective: This study aimed to investigate the expression of natural killer (NK) cell subsets in patients with acquired immune deficiency syndrome (AIDS) and deep fungal infections and the significance of such expression.Methods: A total of 829 patients with AIDS, who were treated in People’s Hospital of Deyang City our hospital between January 2011 and March 2019, were enrolled in the study. They were divided into two groups: those with human immunodeficiency virus (HIV) and invasive fungal infection (IFI) (HIV + IFI) (n = 390) and those with HIV and no IFI (HIV + non-IFI) (n = 439). Another 200 healthy volunteers were enrolled as the control group. The numbers of NK cell subsets in each group were compared.Results: The level of NK cells, number of NK cells in all lymphocytes, proportions of CD56bright, CD56dim, and CD56dim NK cells in NK cells, and the level of CD56–CD16+ NK cells were significantly lower in the HIV + IFI group than in the HIV + non-IFI group and control group (P < 0.05). Moreover, CD4+ T, CD4+/CD8+, and NK cells were negatively correlated with HIV-RNA expression (P < 0.05).Conclusion: A combination of AIDS and deep fungal infection can change the immune status of a patient. This condition can be diagnosed early through the detection of NK cell expression.Keywords: natural killer cells, AIDS, deep fungal infection, CD56, expressionhttps://www.dovepress.com/the-frequency-of-natural-killer-cell-subsets-in-patients-with-acquired-peer-reviewed-article-IDRnatural killer cellsaidsdeep fungal infectioncd56expression |
| spellingShingle | Chen G Qin CJ Wu MZ Liu FF Liu SS Liu L The Frequency of Natural Killer Cell Subsets in Patients with Acquired Immune Deficiency Syndrome with Deep Fungal Infections Infection and Drug Resistance natural killer cells aids deep fungal infection cd56 expression |
| title | The Frequency of Natural Killer Cell Subsets in Patients with Acquired Immune Deficiency Syndrome with Deep Fungal Infections |
| title_full | The Frequency of Natural Killer Cell Subsets in Patients with Acquired Immune Deficiency Syndrome with Deep Fungal Infections |
| title_fullStr | The Frequency of Natural Killer Cell Subsets in Patients with Acquired Immune Deficiency Syndrome with Deep Fungal Infections |
| title_full_unstemmed | The Frequency of Natural Killer Cell Subsets in Patients with Acquired Immune Deficiency Syndrome with Deep Fungal Infections |
| title_short | The Frequency of Natural Killer Cell Subsets in Patients with Acquired Immune Deficiency Syndrome with Deep Fungal Infections |
| title_sort | frequency of natural killer cell subsets in patients with acquired immune deficiency syndrome with deep fungal infections |
| topic | natural killer cells aids deep fungal infection cd56 expression |
| url | https://www.dovepress.com/the-frequency-of-natural-killer-cell-subsets-in-patients-with-acquired-peer-reviewed-article-IDR |
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