Acquisition of optical coherence tomography angiography metrics during hemodialysis procedures: A pilot study
Background and aimsThe observation of optical microcirculation gives us an extraordinary way to directly assess in vivo the responses of human circulation to stress stimuli. We run a pilot study to analyze optical coherence tomography angiography (OCT-A) metrics at determined time-points during a he...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1057165/full |
| _version_ | 1797987934754832384 |
|---|---|
| author | Giuseppe Coppolino Davide Bolignano Pierangela Presta Fausto Francesco Ferrari Giovanna Lionetti Massimiliano Borselli Giorgio Randazzo Michele Andreucci Angelica Bonelli Antonietta Errante Leonardo Campo Davide Mauro Sarah Tripodi Robert Rejdak Mario Damiano Toro Mario Damiano Toro Vincenzo Scorcia Adriano Carnevali |
| author_facet | Giuseppe Coppolino Davide Bolignano Pierangela Presta Fausto Francesco Ferrari Giovanna Lionetti Massimiliano Borselli Giorgio Randazzo Michele Andreucci Angelica Bonelli Antonietta Errante Leonardo Campo Davide Mauro Sarah Tripodi Robert Rejdak Mario Damiano Toro Mario Damiano Toro Vincenzo Scorcia Adriano Carnevali |
| author_sort | Giuseppe Coppolino |
| collection | DOAJ |
| description | Background and aimsThe observation of optical microcirculation gives us an extraordinary way to directly assess in vivo the responses of human circulation to stress stimuli. We run a pilot study to analyze optical coherence tomography angiography (OCT-A) metrics at determined time-points during a hemodialysis (HD) session to understand how these metrics gradually change and to evaluate possible correlations with patients’ characteristics.MethodsAfter the eligibility screening, 15 patients (23 eyes) were included in the study. OCT-A parameters were collected at established time-points: Before treatment (t0), at first hour (t1), at second hour (t2), at third hour (t3), and finally at the end of HD treatment (t4). Patients were finally shared in hypotensive group if they occurred in a hypotensive episode during subsequent month methods or no hypotensive group. The instrument software automatically segmented OCT-A scans into four en-face slabs: The superficial capillary plexus (SCP), the deep capillary plexus (DCP), the outer retinal plexus and the choriocapillaris plexus. In this study we focus on SCP, DCP plexuses.ResultsOverall, the majority of ophthalmic parameters remained unaffected and comparable at dialysis end; a significant reduction being observed at the end vs. starting of HD only for deep capillary plexus (DCP: Whole, fovea, and parafovea) and for central choroid thickness (CCT) (p < 0.05). An overall trend during the session showed in general a decrease with a significance in particular for DCP (whole, fovea, and parafovea) and for CCT (P = 0.006). In the hypotension group, Superficial capillary plexus (SCP: Fovea and parafovea) significantly increased comparing post vs. pre-dialysis values while CCT significantly decreased. Analyzing the trend during treatment only CCT maintained a significant trend (p for trend = 0.002). In the no-hypotension group, neither pre- vs. post-analysis and trend analysis showed a statistical significance.ConclusionMain achievement of our study was to measure, for the first time in literature, single parameters at different time-points of a HD session. As a result of this process we did not notice a brusque decreasing or increasing of OCT-A metrics but we can characterize the different effect of HD on the two distinct areas distinguishing ocular vessels: Retinal and choroidal circulation. As interesting sub-analysis, Hypotensive group showed for CCT a decreasing trend with a difference statistically significant respect to the group with no-hypotension maintaining a constant trend. In our opinion, these results suggest the role of autonomic system on vessel control in patients affected by uremia. |
| first_indexed | 2024-04-11T07:55:49Z |
| format | Article |
| id | doaj.art-69ae6166c355428f9109118fa1708f7e |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T07:55:49Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-69ae6166c355428f9109118fa1708f7e2022-12-22T04:35:56ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-12-01910.3389/fmed.2022.10571651057165Acquisition of optical coherence tomography angiography metrics during hemodialysis procedures: A pilot studyGiuseppe Coppolino0Davide Bolignano1Pierangela Presta2Fausto Francesco Ferrari3Giovanna Lionetti4Massimiliano Borselli5Giorgio Randazzo6Michele Andreucci7Angelica Bonelli8Antonietta Errante9Leonardo Campo10Davide Mauro11Sarah Tripodi12Robert Rejdak13Mario Damiano Toro14Mario Damiano Toro15Vincenzo Scorcia16Adriano Carnevali17Renal Unit, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyRenal Unit, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyRenal Unit, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyDepartment of Ophthalmology, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyDepartment of Ophthalmology, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyDepartment of Ophthalmology, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyDepartment of Ophthalmology, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyRenal Unit, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyRenal Unit, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyRenal Unit, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyRenal Unit, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyRenal Unit, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyDepartment of Ophthalmology, Vigevano-Azienda Socio-Sanitaria Territoriale (ASST) Pavia Civil Hospital, Pavia, ItalyChair and Department of General and Pediatric Ophthalmology, Medical University of Lublin, Lublin, PolandChair and Department of General and Pediatric Ophthalmology, Medical University of Lublin, Lublin, PolandEye Clinic, Public Health Department, University of Naples Federico II, Naples, ItalyDepartment of Ophthalmology, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyDepartment of Ophthalmology, University “Magna Græcia” of Catanzaro, Catanzaro, ItalyBackground and aimsThe observation of optical microcirculation gives us an extraordinary way to directly assess in vivo the responses of human circulation to stress stimuli. We run a pilot study to analyze optical coherence tomography angiography (OCT-A) metrics at determined time-points during a hemodialysis (HD) session to understand how these metrics gradually change and to evaluate possible correlations with patients’ characteristics.MethodsAfter the eligibility screening, 15 patients (23 eyes) were included in the study. OCT-A parameters were collected at established time-points: Before treatment (t0), at first hour (t1), at second hour (t2), at third hour (t3), and finally at the end of HD treatment (t4). Patients were finally shared in hypotensive group if they occurred in a hypotensive episode during subsequent month methods or no hypotensive group. The instrument software automatically segmented OCT-A scans into four en-face slabs: The superficial capillary plexus (SCP), the deep capillary plexus (DCP), the outer retinal plexus and the choriocapillaris plexus. In this study we focus on SCP, DCP plexuses.ResultsOverall, the majority of ophthalmic parameters remained unaffected and comparable at dialysis end; a significant reduction being observed at the end vs. starting of HD only for deep capillary plexus (DCP: Whole, fovea, and parafovea) and for central choroid thickness (CCT) (p < 0.05). An overall trend during the session showed in general a decrease with a significance in particular for DCP (whole, fovea, and parafovea) and for CCT (P = 0.006). In the hypotension group, Superficial capillary plexus (SCP: Fovea and parafovea) significantly increased comparing post vs. pre-dialysis values while CCT significantly decreased. Analyzing the trend during treatment only CCT maintained a significant trend (p for trend = 0.002). In the no-hypotension group, neither pre- vs. post-analysis and trend analysis showed a statistical significance.ConclusionMain achievement of our study was to measure, for the first time in literature, single parameters at different time-points of a HD session. As a result of this process we did not notice a brusque decreasing or increasing of OCT-A metrics but we can characterize the different effect of HD on the two distinct areas distinguishing ocular vessels: Retinal and choroidal circulation. As interesting sub-analysis, Hypotensive group showed for CCT a decreasing trend with a difference statistically significant respect to the group with no-hypotension maintaining a constant trend. In our opinion, these results suggest the role of autonomic system on vessel control in patients affected by uremia.https://www.frontiersin.org/articles/10.3389/fmed.2022.1057165/fullintradialytic hypotensionhemodialysisoptical coherence tomography angiographycirculationchoroidal vessel |
| spellingShingle | Giuseppe Coppolino Davide Bolignano Pierangela Presta Fausto Francesco Ferrari Giovanna Lionetti Massimiliano Borselli Giorgio Randazzo Michele Andreucci Angelica Bonelli Antonietta Errante Leonardo Campo Davide Mauro Sarah Tripodi Robert Rejdak Mario Damiano Toro Mario Damiano Toro Vincenzo Scorcia Adriano Carnevali Acquisition of optical coherence tomography angiography metrics during hemodialysis procedures: A pilot study Frontiers in Medicine intradialytic hypotension hemodialysis optical coherence tomography angiography circulation choroidal vessel |
| title | Acquisition of optical coherence tomography angiography metrics during hemodialysis procedures: A pilot study |
| title_full | Acquisition of optical coherence tomography angiography metrics during hemodialysis procedures: A pilot study |
| title_fullStr | Acquisition of optical coherence tomography angiography metrics during hemodialysis procedures: A pilot study |
| title_full_unstemmed | Acquisition of optical coherence tomography angiography metrics during hemodialysis procedures: A pilot study |
| title_short | Acquisition of optical coherence tomography angiography metrics during hemodialysis procedures: A pilot study |
| title_sort | acquisition of optical coherence tomography angiography metrics during hemodialysis procedures a pilot study |
| topic | intradialytic hypotension hemodialysis optical coherence tomography angiography circulation choroidal vessel |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1057165/full |
| work_keys_str_mv | AT giuseppecoppolino acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT davidebolignano acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT pierangelapresta acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT faustofrancescoferrari acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT giovannalionetti acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT massimilianoborselli acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT giorgiorandazzo acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT micheleandreucci acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT angelicabonelli acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT antoniettaerrante acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT leonardocampo acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT davidemauro acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT sarahtripodi acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT robertrejdak acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT mariodamianotoro acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT mariodamianotoro acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT vincenzoscorcia acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy AT adrianocarnevali acquisitionofopticalcoherencetomographyangiographymetricsduringhemodialysisproceduresapilotstudy |