Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia
Achilles tendon xanthomas are associated with increased cardiovascular risk in patients with familial hypercholesterolemia (FH). Oxidized low density lipoprotein (OxLDL), the antibodies against OxLDL, and the LDL-associated phospholipase A2 (Lp-PLA2) may play important roles in atherogenesis. We inv...
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| Format: | Article |
| Language: | English |
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Elsevier
2006-10-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S002222752043408X |
| _version_ | 1818671414029320192 |
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| author | Sofia G. Tsouli Dimitrios N. Kiortsis Evangelia S. Lourida Vasilios Xydis Loukas D. Tsironis Maria I. Argyropoulou Moses Elisaf Alexandros D. Tselepis |
| author_facet | Sofia G. Tsouli Dimitrios N. Kiortsis Evangelia S. Lourida Vasilios Xydis Loukas D. Tsironis Maria I. Argyropoulou Moses Elisaf Alexandros D. Tselepis |
| author_sort | Sofia G. Tsouli |
| collection | DOAJ |
| description | Achilles tendon xanthomas are associated with increased cardiovascular risk in patients with familial hypercholesterolemia (FH). Oxidized low density lipoprotein (OxLDL), the antibodies against OxLDL, and the LDL-associated phospholipase A2 (Lp-PLA2) may play important roles in atherogenesis. We investigated the possible association between plasma levels of OxLDL, Lp-PLA2 activity, and autoantibody titers against various types of mildly OxLDL with Achilles tendon thickness (ATT). ATT was determined by sonography in 80 unrelated heterozygous FH patients. Three different types of mildly OxLDL were prepared: OxLDLL, OxLDLP, and OxLDLD, at the end of the lag, propagation, and decomposition phases of oxidation, respectively. Similar types of OxLDL were also prepared after inactivation of the LDL-associated Lp-PLA2. These types were denoted OxLDL(−)L, OxLDL(−)P, and OxLDL(−)D. FH patients exhibited significantly higher plasma OxLDL levels and serum IgG titers against OxLDLP and OxLDLD compared with 40 normolipidemic apparently healthy controls. ATT values were positively correlated with autoantibody titers against OxLDLP and OxLDLD; however, in multiple regression analysis, ATT was independently associated only with the autoantibody titers against OxLDLD. We conclude that the IgG autoantibody titers against OxLDLD but not OxLDL or Lp-PLA2 may play an important role in the pathogenesis of Achilles tendon xanthomas in FH patients. |
| first_indexed | 2024-12-17T07:23:37Z |
| format | Article |
| id | doaj.art-69b1206b4d50498782458634914eeaeb |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T07:23:37Z |
| publishDate | 2006-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-69b1206b4d50498782458634914eeaeb2022-12-21T21:58:41ZengElsevierJournal of Lipid Research0022-22752006-10-01471022082214Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemiaSofia G. Tsouli0Dimitrios N. Kiortsis1Evangelia S. Lourida2Vasilios Xydis3Loukas D. Tsironis4Maria I. Argyropoulou5Moses Elisaf6Alexandros D. Tselepis7Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, GreeceLaboratory of Physiology, Medical School, University of Ioannina, 45110 Ioannina, GreeceLaboratory of Biochemistry, Department of Chemistry, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Radiology, Medical School, University of Ioannina, 45110 Ioannina, GreeceLaboratory of Biochemistry, Department of Chemistry, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Radiology, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, GreeceLaboratory of Biochemistry, Department of Chemistry, Medical School, University of Ioannina, 45110 Ioannina, GreeceAchilles tendon xanthomas are associated with increased cardiovascular risk in patients with familial hypercholesterolemia (FH). Oxidized low density lipoprotein (OxLDL), the antibodies against OxLDL, and the LDL-associated phospholipase A2 (Lp-PLA2) may play important roles in atherogenesis. We investigated the possible association between plasma levels of OxLDL, Lp-PLA2 activity, and autoantibody titers against various types of mildly OxLDL with Achilles tendon thickness (ATT). ATT was determined by sonography in 80 unrelated heterozygous FH patients. Three different types of mildly OxLDL were prepared: OxLDLL, OxLDLP, and OxLDLD, at the end of the lag, propagation, and decomposition phases of oxidation, respectively. Similar types of OxLDL were also prepared after inactivation of the LDL-associated Lp-PLA2. These types were denoted OxLDL(−)L, OxLDL(−)P, and OxLDL(−)D. FH patients exhibited significantly higher plasma OxLDL levels and serum IgG titers against OxLDLP and OxLDLD compared with 40 normolipidemic apparently healthy controls. ATT values were positively correlated with autoantibody titers against OxLDLP and OxLDLD; however, in multiple regression analysis, ATT was independently associated only with the autoantibody titers against OxLDLD. We conclude that the IgG autoantibody titers against OxLDLD but not OxLDL or Lp-PLA2 may play an important role in the pathogenesis of Achilles tendon xanthomas in FH patients.http://www.sciencedirect.com/science/article/pii/S002222752043408Xantibodyoxidized low density lipoproteinplatelet-activating factor acetylhydrolasephospholipase A2 |
| spellingShingle | Sofia G. Tsouli Dimitrios N. Kiortsis Evangelia S. Lourida Vasilios Xydis Loukas D. Tsironis Maria I. Argyropoulou Moses Elisaf Alexandros D. Tselepis Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia Journal of Lipid Research antibody oxidized low density lipoprotein platelet-activating factor acetylhydrolase phospholipase A2 |
| title | Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia |
| title_full | Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia |
| title_fullStr | Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia |
| title_full_unstemmed | Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia |
| title_short | Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia |
| title_sort | autoantibody titers against oxldl are correlated with achilles tendon thickness in patients with familial hypercholesterolemia |
| topic | antibody oxidized low density lipoprotein platelet-activating factor acetylhydrolase phospholipase A2 |
| url | http://www.sciencedirect.com/science/article/pii/S002222752043408X |
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