Prospective evaluation of a closed-incision negative pressure wound therapy system in kidney transplantation and its association with wound complications
IntroductionWound complications can cause considerable morbidity in kidney transplantation. Closed-incision negative pressure wound therapy (ciNPWT) systems have been efficacious in reducing wound complications across surgical specialties. The aims of this study were to evaluate the use of ciNPWT, P...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Nephrology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneph.2024.1352363/full |
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| author | Susanna Lam Susanna Lam Susanna Lam Susanna Lam Annie Huynh Tracey Ying Tracey Ying Tracey Ying Charbel Sandroussi Charbel Sandroussi Charbel Sandroussi David Gracey David Gracey David Gracey Henry C. Pleass Henry C. Pleass Steve Chadban Steve Chadban Steve Chadban Jerome M. Laurence Jerome M. Laurence Jerome M. Laurence Jerome M. Laurence |
| author_facet | Susanna Lam Susanna Lam Susanna Lam Susanna Lam Annie Huynh Tracey Ying Tracey Ying Tracey Ying Charbel Sandroussi Charbel Sandroussi Charbel Sandroussi David Gracey David Gracey David Gracey Henry C. Pleass Henry C. Pleass Steve Chadban Steve Chadban Steve Chadban Jerome M. Laurence Jerome M. Laurence Jerome M. Laurence Jerome M. Laurence |
| author_sort | Susanna Lam |
| collection | DOAJ |
| description | IntroductionWound complications can cause considerable morbidity in kidney transplantation. Closed-incision negative pressure wound therapy (ciNPWT) systems have been efficacious in reducing wound complications across surgical specialties. The aims of this study were to evaluate the use of ciNPWT, Prevena™, in kidney transplant recipients and to determine any association with wound complications.Material and methodsA single-center, prospective observational cohort study was performed in 2018. A total of 30 consecutive kidney transplant recipients deemed at high risk for wound complications received ciNPWT, and the results were compared to those of a historical cohort of subjects who received conventional dressings. Analysis for recipients with obesity and propensity score matching were performed.ResultsIn total, 127 subjects were included in the analysis. Of these, 30 received a ciNPWT dressing and were compared with 97 subjects from a non-study historical control group who had conventional dressing. The overall wound complication rate was 21.3% (27/127). There was no reduction in the rate of wound complications with ciNPWT when compared with conventional dressing [23.3% (7/30) and 20.6% (20/97), respectively, p = 0.75]. In the obese subset (BMI ≥30 kg/m2), there was no significant reduction in wound complications [31.1% (5/16) and 36.8% (7/19), respectively, p = 0.73]. Propensity score matching yielded 26 matched pairs with equivalent rates of wound complications (23.1%, 6/26).ConclusionThis is the first reported cohort study evaluating the use of ciNPWT in kidney transplantation. While ciNPWT is safe and well tolerated, it is not associated with a statistically significant reduction in wound complications when compared to conventional dressing. The findings from this study will be used to inform future studies associated with ciNPWT in kidney transplantation. |
| first_indexed | 2024-03-07T21:20:55Z |
| format | Article |
| id | doaj.art-69b18beea5c247be88139f93e29b003f |
| institution | Directory Open Access Journal |
| issn | 2813-0626 |
| language | English |
| last_indexed | 2024-03-07T21:20:55Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nephrology |
| spelling | doaj.art-69b18beea5c247be88139f93e29b003f2024-02-27T12:45:55ZengFrontiers Media S.A.Frontiers in Nephrology2813-06262024-02-01410.3389/fneph.2024.13523631352363Prospective evaluation of a closed-incision negative pressure wound therapy system in kidney transplantation and its association with wound complicationsSusanna Lam0Susanna Lam1Susanna Lam2Susanna Lam3Annie Huynh4Tracey Ying5Tracey Ying6Tracey Ying7Charbel Sandroussi8Charbel Sandroussi9Charbel Sandroussi10David Gracey11David Gracey12David Gracey13Henry C. Pleass14Henry C. Pleass15Steve Chadban16Steve Chadban17Steve Chadban18Jerome M. Laurence19Jerome M. Laurence20Jerome M. Laurence21Jerome M. Laurence22Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaTransplantation Services, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaInstitute of Academic Surgery, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaSydney Medical School, University of Sydney, Sydney, NSW, AustraliaTransplantation Services, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaDepartment of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaSydney Medical School, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, University of Sydney, Sydney, NSW, AustraliaTransplantation Services, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaInstitute of Academic Surgery, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaSydney Medical School, University of Sydney, Sydney, NSW, AustraliaDepartment of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaSydney Medical School, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, University of Sydney, Sydney, NSW, AustraliaTransplantation Services, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaSydney Medical School, University of Sydney, Sydney, NSW, AustraliaDepartment of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaSydney Medical School, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, University of Sydney, Sydney, NSW, AustraliaTransplantation Services, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaInstitute of Academic Surgery, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaSydney Medical School, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, University of Sydney, Sydney, NSW, AustraliaIntroductionWound complications can cause considerable morbidity in kidney transplantation. Closed-incision negative pressure wound therapy (ciNPWT) systems have been efficacious in reducing wound complications across surgical specialties. The aims of this study were to evaluate the use of ciNPWT, Prevena™, in kidney transplant recipients and to determine any association with wound complications.Material and methodsA single-center, prospective observational cohort study was performed in 2018. A total of 30 consecutive kidney transplant recipients deemed at high risk for wound complications received ciNPWT, and the results were compared to those of a historical cohort of subjects who received conventional dressings. Analysis for recipients with obesity and propensity score matching were performed.ResultsIn total, 127 subjects were included in the analysis. Of these, 30 received a ciNPWT dressing and were compared with 97 subjects from a non-study historical control group who had conventional dressing. The overall wound complication rate was 21.3% (27/127). There was no reduction in the rate of wound complications with ciNPWT when compared with conventional dressing [23.3% (7/30) and 20.6% (20/97), respectively, p = 0.75]. In the obese subset (BMI ≥30 kg/m2), there was no significant reduction in wound complications [31.1% (5/16) and 36.8% (7/19), respectively, p = 0.73]. Propensity score matching yielded 26 matched pairs with equivalent rates of wound complications (23.1%, 6/26).ConclusionThis is the first reported cohort study evaluating the use of ciNPWT in kidney transplantation. While ciNPWT is safe and well tolerated, it is not associated with a statistically significant reduction in wound complications when compared to conventional dressing. The findings from this study will be used to inform future studies associated with ciNPWT in kidney transplantation.https://www.frontiersin.org/articles/10.3389/fneph.2024.1352363/fullwound complicationkidney transplantclosed incision negative pressure wound therapyclosed incision negative pressureclosed incision management |
| spellingShingle | Susanna Lam Susanna Lam Susanna Lam Susanna Lam Annie Huynh Tracey Ying Tracey Ying Tracey Ying Charbel Sandroussi Charbel Sandroussi Charbel Sandroussi David Gracey David Gracey David Gracey Henry C. Pleass Henry C. Pleass Steve Chadban Steve Chadban Steve Chadban Jerome M. Laurence Jerome M. Laurence Jerome M. Laurence Jerome M. Laurence Prospective evaluation of a closed-incision negative pressure wound therapy system in kidney transplantation and its association with wound complications Frontiers in Nephrology wound complication kidney transplant closed incision negative pressure wound therapy closed incision negative pressure closed incision management |
| title | Prospective evaluation of a closed-incision negative pressure wound therapy system in kidney transplantation and its association with wound complications |
| title_full | Prospective evaluation of a closed-incision negative pressure wound therapy system in kidney transplantation and its association with wound complications |
| title_fullStr | Prospective evaluation of a closed-incision negative pressure wound therapy system in kidney transplantation and its association with wound complications |
| title_full_unstemmed | Prospective evaluation of a closed-incision negative pressure wound therapy system in kidney transplantation and its association with wound complications |
| title_short | Prospective evaluation of a closed-incision negative pressure wound therapy system in kidney transplantation and its association with wound complications |
| title_sort | prospective evaluation of a closed incision negative pressure wound therapy system in kidney transplantation and its association with wound complications |
| topic | wound complication kidney transplant closed incision negative pressure wound therapy closed incision negative pressure closed incision management |
| url | https://www.frontiersin.org/articles/10.3389/fneph.2024.1352363/full |
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