m6A demethylase FTO and osteoporosis: potential therapeutic interventions
Osteoporosis is a common bone disease, characterized by a descent in bone mass due to the dysregulation of bone homeostasis. Although different studies have identified an association between osteoporosis and epigenetic alterations in osteogenic genes, the mechanisms of osteoporosis remain unclear. N...
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| Format: | Article |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1275475/full |
| _version_ | 1797629425048616960 |
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| author | Mei Huang Jianmin Guo Lifei Liu Lifei Liu Haiming Jin Xi Chen Jun Zou |
| author_facet | Mei Huang Jianmin Guo Lifei Liu Lifei Liu Haiming Jin Xi Chen Jun Zou |
| author_sort | Mei Huang |
| collection | DOAJ |
| description | Osteoporosis is a common bone disease, characterized by a descent in bone mass due to the dysregulation of bone homeostasis. Although different studies have identified an association between osteoporosis and epigenetic alterations in osteogenic genes, the mechanisms of osteoporosis remain unclear. N6-methyladenosine (m6A) modification is a methylated adenosine nucleotide, which regulates the translocation, exporting, translation, and decay of RNA. FTO is the first identified m6A demethylase, which eliminates m6A modifications from RNAs. Variation in FTO disturbs m6A methylation in RNAs to regulate cell proliferation, differentiation, and apoptosis. Besides, FTO as an obesity-associated gene, also affects osteogenesis by regulating adipogenesis. Pharmacological inhibition of FTO markedly altered bone mass, bone mineral density and the distribution of adipose tissue. Small molecules which modulate FTO function are potentially novel remedies to the treatment of osteoporosis by adjusting the m6A levels. This article reviews the roles of m6A demethylase FTO in regulating bone metabolism and osteoporosis. |
| first_indexed | 2024-03-11T10:54:10Z |
| format | Article |
| id | doaj.art-69b1cb801b764a94b985b8bfeb18a07e |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-11T10:54:10Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-69b1cb801b764a94b985b8bfeb18a07e2023-11-13T11:53:31ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-11-011110.3389/fcell.2023.12754751275475m6A demethylase FTO and osteoporosis: potential therapeutic interventionsMei Huang0Jianmin Guo1Lifei Liu2Lifei Liu3Haiming Jin4Xi Chen5Jun Zou6School of Kinesiology, Shanghai University of Sport, Shanghai, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai, ChinaDepartment of Rehabilitation, The People’s Hospital of Liaoning Province, Shenyang, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of Sports Science, Wenzhou Medical University, Wenzhou, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai, ChinaOsteoporosis is a common bone disease, characterized by a descent in bone mass due to the dysregulation of bone homeostasis. Although different studies have identified an association between osteoporosis and epigenetic alterations in osteogenic genes, the mechanisms of osteoporosis remain unclear. N6-methyladenosine (m6A) modification is a methylated adenosine nucleotide, which regulates the translocation, exporting, translation, and decay of RNA. FTO is the first identified m6A demethylase, which eliminates m6A modifications from RNAs. Variation in FTO disturbs m6A methylation in RNAs to regulate cell proliferation, differentiation, and apoptosis. Besides, FTO as an obesity-associated gene, also affects osteogenesis by regulating adipogenesis. Pharmacological inhibition of FTO markedly altered bone mass, bone mineral density and the distribution of adipose tissue. Small molecules which modulate FTO function are potentially novel remedies to the treatment of osteoporosis by adjusting the m6A levels. This article reviews the roles of m6A demethylase FTO in regulating bone metabolism and osteoporosis.https://www.frontiersin.org/articles/10.3389/fcell.2023.1275475/fullFTOm6A methylationbone metabolismFTO inhibitorosteoporosis |
| spellingShingle | Mei Huang Jianmin Guo Lifei Liu Lifei Liu Haiming Jin Xi Chen Jun Zou m6A demethylase FTO and osteoporosis: potential therapeutic interventions Frontiers in Cell and Developmental Biology FTO m6A methylation bone metabolism FTO inhibitor osteoporosis |
| title | m6A demethylase FTO and osteoporosis: potential therapeutic interventions |
| title_full | m6A demethylase FTO and osteoporosis: potential therapeutic interventions |
| title_fullStr | m6A demethylase FTO and osteoporosis: potential therapeutic interventions |
| title_full_unstemmed | m6A demethylase FTO and osteoporosis: potential therapeutic interventions |
| title_short | m6A demethylase FTO and osteoporosis: potential therapeutic interventions |
| title_sort | m6a demethylase fto and osteoporosis potential therapeutic interventions |
| topic | FTO m6A methylation bone metabolism FTO inhibitor osteoporosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1275475/full |
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