Immunological Network in Head and Neck Squamous Cell Carcinoma—A Prognostic Tool Beyond HPV Status
Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that affects more than 800,000 patients worldwide each year. The variability of HNSCC is associated with differences in the carcinogenesis processes that are caused by two major etiological agents, namely, alcohol/tobacc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.01701/full |
| _version_ | 1818513694631395328 |
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| author | Anna Fialová Vladimír Koucký Vladimír Koucký Martina Hajdušková Kamila Hladíková Radek Špíšek |
| author_facet | Anna Fialová Vladimír Koucký Vladimír Koucký Martina Hajdušková Kamila Hladíková Radek Špíšek |
| author_sort | Anna Fialová |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that affects more than 800,000 patients worldwide each year. The variability of HNSCC is associated with differences in the carcinogenesis processes that are caused by two major etiological agents, namely, alcohol/tobacco, and human papillomavirus (HPV). Compared to non-virally induced carcinomas, the oropharyngeal tumors associated with HPV infection show markedly better clinical outcomes and are characterized by an immunologically “hot” landscape with high levels of tumor-infiltrating lymphocytes. However, the standard of care remains the same for both HPV-positive and HPV-negative HNSCC. Surprisingly, treatment de-escalation trials have not shown any clinical benefit in patients with HPV-positive tumors to date, most likely due to insufficient patient stratification. The in-depth analysis of the immune response, which places an emphasis on tumor-infiltrating immune cells, is a widely accepted prognostic tool that might significantly improve both the stratification of HNSCC patients in de-escalation trials and the development of novel immunotherapeutic approaches. |
| first_indexed | 2024-12-11T00:05:09Z |
| format | Article |
| id | doaj.art-69b2b38ea0614cd48f00476d6b101abd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T00:05:09Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-69b2b38ea0614cd48f00476d6b101abd2022-12-22T01:28:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-09-011010.3389/fonc.2020.01701548786Immunological Network in Head and Neck Squamous Cell Carcinoma—A Prognostic Tool Beyond HPV StatusAnna Fialová0Vladimír Koucký1Vladimír Koucký2Martina Hajdušková3Kamila Hladíková4Radek Špíšek5Sotio, Prague, CzechiaSotio, Prague, CzechiaDepartment of Otorhinolaryngology and Head and Neck Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, Prague, CzechiaBioGraphix, Hluboká nad Vltavou, CzechiaSotio, Prague, CzechiaSotio, Prague, CzechiaHead and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that affects more than 800,000 patients worldwide each year. The variability of HNSCC is associated with differences in the carcinogenesis processes that are caused by two major etiological agents, namely, alcohol/tobacco, and human papillomavirus (HPV). Compared to non-virally induced carcinomas, the oropharyngeal tumors associated with HPV infection show markedly better clinical outcomes and are characterized by an immunologically “hot” landscape with high levels of tumor-infiltrating lymphocytes. However, the standard of care remains the same for both HPV-positive and HPV-negative HNSCC. Surprisingly, treatment de-escalation trials have not shown any clinical benefit in patients with HPV-positive tumors to date, most likely due to insufficient patient stratification. The in-depth analysis of the immune response, which places an emphasis on tumor-infiltrating immune cells, is a widely accepted prognostic tool that might significantly improve both the stratification of HNSCC patients in de-escalation trials and the development of novel immunotherapeutic approaches.https://www.frontiersin.org/article/10.3389/fonc.2020.01701/fullhead and neck squamous cell carcinomahuman papillomavirus (HPV)tumor microenvironmentimmune infiltrateantitumor immune responsetreatment de-escalation |
| spellingShingle | Anna Fialová Vladimír Koucký Vladimír Koucký Martina Hajdušková Kamila Hladíková Radek Špíšek Immunological Network in Head and Neck Squamous Cell Carcinoma—A Prognostic Tool Beyond HPV Status Frontiers in Oncology head and neck squamous cell carcinoma human papillomavirus (HPV) tumor microenvironment immune infiltrate antitumor immune response treatment de-escalation |
| title | Immunological Network in Head and Neck Squamous Cell Carcinoma—A Prognostic Tool Beyond HPV Status |
| title_full | Immunological Network in Head and Neck Squamous Cell Carcinoma—A Prognostic Tool Beyond HPV Status |
| title_fullStr | Immunological Network in Head and Neck Squamous Cell Carcinoma—A Prognostic Tool Beyond HPV Status |
| title_full_unstemmed | Immunological Network in Head and Neck Squamous Cell Carcinoma—A Prognostic Tool Beyond HPV Status |
| title_short | Immunological Network in Head and Neck Squamous Cell Carcinoma—A Prognostic Tool Beyond HPV Status |
| title_sort | immunological network in head and neck squamous cell carcinoma a prognostic tool beyond hpv status |
| topic | head and neck squamous cell carcinoma human papillomavirus (HPV) tumor microenvironment immune infiltrate antitumor immune response treatment de-escalation |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.01701/full |
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