| Summary: | Intro: A number of patients after acute diarrhea of bacterial etiology (ADBE) have irritable bowel syndrome (IBS). The aim of the study: to evaluate the lipid profile in patients with ADBE and determine its significance in the development of IBS. Methods: Patients with ADBE 18-65 years old(n=50) were included in the study. The levels of triglycerides, lysophosphatidylcholine, sphingomyelin, phosphatidylcholine, phosphatidylethanolamine were detected. Findings: Hypertriglyceridemia was observed in 62% of patients, an increased level of phosphatidylcholine (Me=58.6%) - in 90%, lysophosphatidylcholine (Me=11.24%) - in 56%, a decreased level of phosphatidylethanolamine (Me=14.5%) in 72% of patients, sphingomyelin (Me=13.4%) in 24%. Subsequently, IBS developed in 16 (32%) patients. A ROC analysis was performed to assess the risk of developing IBS. For the association of IBS development with triglyceride levels, AUC was 0.889±0.051(95%CI:0.788-0.989; p<0,001). Cut-off point was 2.115 mmol/l. This or more high triglyceride level predicts the significant risk of IBS. The sensitivity was 85.7%, specificity - 83.3%. The AUC corresponding to the relationship between the IBS and level of phosphatidylcholine was 0.827±0.058(95%CI:0.713-0.942; p<0.001). The value of phosphatidylcholine at the cut-off was 63.82%. This or more high level of predicts a significant risk of IBS, the sensitivity and specificity were 78.6% and 83.3%. AUC for dependence of IBS developing and the level of phosphatidylethanolamine, was 0.853±0.055(95% CI:0.746-0.960; p<0.001), cut-off was 14.25%. This or more low level predicts a high risk of IBS developing. The sensitivity and specificity were 100% and 77.8%. Discussion: In patients with ADBE who have a high risk of developing IBS, changes in the lipid spectrum were an increase in the level of triglycerides and phosphatidylcholine and decrease of phosphatidylethanolamine level. Conclusion: The obtained lipid profile data can be taken into account for the identification of patients at high risk of IBS and the selection of drugs for its prevention.
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