CHANGES IN THE LIPID SPECTRUM IN ACUTE BACTERIAL DIARRHEA AS PREDICTORS OF IRRITABLE BOWEL SYNDROME
Intro: A number of patients after acute diarrhea of bacterial etiology (ADBE) have irritable bowel syndrome (IBS). The aim of the study: to evaluate the lipid profile in patients with ADBE and determine its significance in the development of IBS. Methods: Patients with ADBE 18-65 years old(n=50) wer...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223006033 |
| _version_ | 1797745257568272384 |
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| author | R. Tlyustangelova N. Pshenichnaya A. Tsikunib |
| author_facet | R. Tlyustangelova N. Pshenichnaya A. Tsikunib |
| author_sort | R. Tlyustangelova |
| collection | DOAJ |
| description | Intro: A number of patients after acute diarrhea of bacterial etiology (ADBE) have irritable bowel syndrome (IBS). The aim of the study: to evaluate the lipid profile in patients with ADBE and determine its significance in the development of IBS. Methods: Patients with ADBE 18-65 years old(n=50) were included in the study. The levels of triglycerides, lysophosphatidylcholine, sphingomyelin, phosphatidylcholine, phosphatidylethanolamine were detected. Findings: Hypertriglyceridemia was observed in 62% of patients, an increased level of phosphatidylcholine (Me=58.6%) - in 90%, lysophosphatidylcholine (Me=11.24%) - in 56%, a decreased level of phosphatidylethanolamine (Me=14.5%) in 72% of patients, sphingomyelin (Me=13.4%) in 24%. Subsequently, IBS developed in 16 (32%) patients. A ROC analysis was performed to assess the risk of developing IBS. For the association of IBS development with triglyceride levels, AUC was 0.889±0.051(95%CI:0.788-0.989; p<0,001). Cut-off point was 2.115 mmol/l. This or more high triglyceride level predicts the significant risk of IBS. The sensitivity was 85.7%, specificity - 83.3%. The AUC corresponding to the relationship between the IBS and level of phosphatidylcholine was 0.827±0.058(95%CI:0.713-0.942; p<0.001). The value of phosphatidylcholine at the cut-off was 63.82%. This or more high level of predicts a significant risk of IBS, the sensitivity and specificity were 78.6% and 83.3%. AUC for dependence of IBS developing and the level of phosphatidylethanolamine, was 0.853±0.055(95% CI:0.746-0.960; p<0.001), cut-off was 14.25%. This or more low level predicts a high risk of IBS developing. The sensitivity and specificity were 100% and 77.8%. Discussion: In patients with ADBE who have a high risk of developing IBS, changes in the lipid spectrum were an increase in the level of triglycerides and phosphatidylcholine and decrease of phosphatidylethanolamine level. Conclusion: The obtained lipid profile data can be taken into account for the identification of patients at high risk of IBS and the selection of drugs for its prevention. |
| first_indexed | 2024-03-12T15:21:49Z |
| format | Article |
| id | doaj.art-69b555bc99d04d55ad0c8b3ce92eeeb7 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-12T15:21:49Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-69b555bc99d04d55ad0c8b3ce92eeeb72023-08-11T05:32:18ZengElsevierInternational Journal of Infectious Diseases1201-97122023-08-01134S13CHANGES IN THE LIPID SPECTRUM IN ACUTE BACTERIAL DIARRHEA AS PREDICTORS OF IRRITABLE BOWEL SYNDROMER. Tlyustangelova0N. Pshenichnaya1A. Tsikunib2Adygea Republican Clinical Infectious Diseases Hospital, Infectious Diseases Department No. 1, Maykop, Russian FederationCentral Research Institute of Epidemiology, Department of Infectious Diseases and Epidemiology, Moscow, Russian FederationAdygea State University, Department of Chemistry, Maykop, Russian FederationIntro: A number of patients after acute diarrhea of bacterial etiology (ADBE) have irritable bowel syndrome (IBS). The aim of the study: to evaluate the lipid profile in patients with ADBE and determine its significance in the development of IBS. Methods: Patients with ADBE 18-65 years old(n=50) were included in the study. The levels of triglycerides, lysophosphatidylcholine, sphingomyelin, phosphatidylcholine, phosphatidylethanolamine were detected. Findings: Hypertriglyceridemia was observed in 62% of patients, an increased level of phosphatidylcholine (Me=58.6%) - in 90%, lysophosphatidylcholine (Me=11.24%) - in 56%, a decreased level of phosphatidylethanolamine (Me=14.5%) in 72% of patients, sphingomyelin (Me=13.4%) in 24%. Subsequently, IBS developed in 16 (32%) patients. A ROC analysis was performed to assess the risk of developing IBS. For the association of IBS development with triglyceride levels, AUC was 0.889±0.051(95%CI:0.788-0.989; p<0,001). Cut-off point was 2.115 mmol/l. This or more high triglyceride level predicts the significant risk of IBS. The sensitivity was 85.7%, specificity - 83.3%. The AUC corresponding to the relationship between the IBS and level of phosphatidylcholine was 0.827±0.058(95%CI:0.713-0.942; p<0.001). The value of phosphatidylcholine at the cut-off was 63.82%. This or more high level of predicts a significant risk of IBS, the sensitivity and specificity were 78.6% and 83.3%. AUC for dependence of IBS developing and the level of phosphatidylethanolamine, was 0.853±0.055(95% CI:0.746-0.960; p<0.001), cut-off was 14.25%. This or more low level predicts a high risk of IBS developing. The sensitivity and specificity were 100% and 77.8%. Discussion: In patients with ADBE who have a high risk of developing IBS, changes in the lipid spectrum were an increase in the level of triglycerides and phosphatidylcholine and decrease of phosphatidylethanolamine level. Conclusion: The obtained lipid profile data can be taken into account for the identification of patients at high risk of IBS and the selection of drugs for its prevention.http://www.sciencedirect.com/science/article/pii/S1201971223006033 |
| spellingShingle | R. Tlyustangelova N. Pshenichnaya A. Tsikunib CHANGES IN THE LIPID SPECTRUM IN ACUTE BACTERIAL DIARRHEA AS PREDICTORS OF IRRITABLE BOWEL SYNDROME International Journal of Infectious Diseases |
| title | CHANGES IN THE LIPID SPECTRUM IN ACUTE BACTERIAL DIARRHEA AS PREDICTORS OF IRRITABLE BOWEL SYNDROME |
| title_full | CHANGES IN THE LIPID SPECTRUM IN ACUTE BACTERIAL DIARRHEA AS PREDICTORS OF IRRITABLE BOWEL SYNDROME |
| title_fullStr | CHANGES IN THE LIPID SPECTRUM IN ACUTE BACTERIAL DIARRHEA AS PREDICTORS OF IRRITABLE BOWEL SYNDROME |
| title_full_unstemmed | CHANGES IN THE LIPID SPECTRUM IN ACUTE BACTERIAL DIARRHEA AS PREDICTORS OF IRRITABLE BOWEL SYNDROME |
| title_short | CHANGES IN THE LIPID SPECTRUM IN ACUTE BACTERIAL DIARRHEA AS PREDICTORS OF IRRITABLE BOWEL SYNDROME |
| title_sort | changes in the lipid spectrum in acute bacterial diarrhea as predictors of irritable bowel syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223006033 |
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