Obsessive-Compulsive Symptoms Associated with Clozapine and Risperidone Treatment: Three Case Reports and Review of the Literature
Treatment-emergent obsessive-compulsive symptoms (OCSs) have raised concern since the widespread introduction of serotonin-dopamine antagonists (SDAs) for the treatment of schizophrenia. Further investigations of SDA-emergent OCSs and their response to anti-obsessional agents will be beneficial for...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2004-06-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X09701214 |
| _version_ | 1819199235908698112 |
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| author | Chiao-Li Ke Cheng-Fang Yen Cheng-Chung Chen Shang-Ju Yang Weilun Chung Ming-Jen Yang |
| author_facet | Chiao-Li Ke Cheng-Fang Yen Cheng-Chung Chen Shang-Ju Yang Weilun Chung Ming-Jen Yang |
| author_sort | Chiao-Li Ke |
| collection | DOAJ |
| description | Treatment-emergent obsessive-compulsive symptoms (OCSs) have raised concern since the widespread introduction of serotonin-dopamine antagonists (SDAs) for the treatment of schizophrenia. Further investigations of SDA-emergent OCSs and their response to anti-obsessional agents will be beneficial for clinicians in helping patients who suffer from this problem. We present three cases of schizophrenia in which distressing OCSs occurred during clozapine or risperidone treatment. OCSs were assessed consecutively using the Yale-Brown Obsessive-Compulsive Scale. The OCSs of these three patients were responsive to anti-obsessional agents, including fluvoxamine, clomipramine, and paroxetine. We also review the current literature and discuss the possible pathophysiology and psychopathology of SDA-emergent OCSs. |
| first_indexed | 2024-12-23T03:13:07Z |
| format | Article |
| id | doaj.art-69b8d6138c1a4c4893e90be504759ec9 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-23T03:13:07Z |
| publishDate | 2004-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-69b8d6138c1a4c4893e90be504759ec92022-12-21T18:02:13ZengWileyKaohsiung Journal of Medical Sciences1607-551X2004-06-0120629530110.1016/S1607-551X(09)70121-4Obsessive-Compulsive Symptoms Associated with Clozapine and Risperidone Treatment: Three Case Reports and Review of the LiteratureChiao-Li KeCheng-Fang YenCheng-Chung ChenShang-Ju YangWeilun ChungMing-Jen YangTreatment-emergent obsessive-compulsive symptoms (OCSs) have raised concern since the widespread introduction of serotonin-dopamine antagonists (SDAs) for the treatment of schizophrenia. Further investigations of SDA-emergent OCSs and their response to anti-obsessional agents will be beneficial for clinicians in helping patients who suffer from this problem. We present three cases of schizophrenia in which distressing OCSs occurred during clozapine or risperidone treatment. OCSs were assessed consecutively using the Yale-Brown Obsessive-Compulsive Scale. The OCSs of these three patients were responsive to anti-obsessional agents, including fluvoxamine, clomipramine, and paroxetine. We also review the current literature and discuss the possible pathophysiology and psychopathology of SDA-emergent OCSs.http://www.sciencedirect.com/science/article/pii/S1607551X09701214obsessive-compulsive symptomsclozapinerisperidoneschizophreniaserotonin-dopamine antagonists |
| spellingShingle | Chiao-Li Ke Cheng-Fang Yen Cheng-Chung Chen Shang-Ju Yang Weilun Chung Ming-Jen Yang Obsessive-Compulsive Symptoms Associated with Clozapine and Risperidone Treatment: Three Case Reports and Review of the Literature Kaohsiung Journal of Medical Sciences obsessive-compulsive symptoms clozapine risperidone schizophrenia serotonin-dopamine antagonists |
| title | Obsessive-Compulsive Symptoms Associated with Clozapine and Risperidone Treatment: Three Case Reports and Review of the Literature |
| title_full | Obsessive-Compulsive Symptoms Associated with Clozapine and Risperidone Treatment: Three Case Reports and Review of the Literature |
| title_fullStr | Obsessive-Compulsive Symptoms Associated with Clozapine and Risperidone Treatment: Three Case Reports and Review of the Literature |
| title_full_unstemmed | Obsessive-Compulsive Symptoms Associated with Clozapine and Risperidone Treatment: Three Case Reports and Review of the Literature |
| title_short | Obsessive-Compulsive Symptoms Associated with Clozapine and Risperidone Treatment: Three Case Reports and Review of the Literature |
| title_sort | obsessive compulsive symptoms associated with clozapine and risperidone treatment three case reports and review of the literature |
| topic | obsessive-compulsive symptoms clozapine risperidone schizophrenia serotonin-dopamine antagonists |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X09701214 |
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