Critical role for Piccolo in synaptic vesicle retrieval
Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocerebellar Hypoplasia type 3, which causes brain atrophy. Here, we address how Piccolo inactivation in rat neurons adversely affects synaptic function and thus may contribute to neuronal loss. Our analysi...
Main Authors: | Frauke Ackermann, Kay Oliver Schink, Christine Bruns, Zsuzsanna Izsvák, F Kent Hamra, Christian Rosenmund, Craig Curtis Garner |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-05-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/46629 |
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