Aberrant Upregulation of Indoleamine 2,3-Dioxygenase 1 Promotes Proliferation and Metastasis of Hepatocellular Carcinoma Cells via Coordinated Activation of AhR and β-Catenin Signaling

Aberrant Upregulation of Indoleamine 2,3-Dioxygenase 1 Promotes Proliferation and Metastasis of Hepatocellular Carcinoma Cells via Coordinated Activation of AhR and β-Catenin Signaling

Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide. Chronic liver inflammation due to hepatitis virus infection and other major effectors is a major risk factor of HCC. Indoleamine 2,3-dioxygenase 1 (IDO1), a heme enzyme highly expressed upon stimulation...

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Bibliographic Details
Main Authors: Chih-Ta Chen, Pei-Hua Wu, Chia-Chi Hu, Hsiao-Ching Nien, Jin-Town Wang, Jin-Chuan Sheu, Lu-Ping Chow
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
hepatocellular carcinoma
proliferation
metastasis
IDO1
kynurenine
AhR
Online Access:https://www.mdpi.com/1422-0067/22/21/11661

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