Vestibular Impairment in Frontotemporal Dementia Syndrome
Background: No studies to date have attempted to evaluate frontotemporal lobar degeneration from the perspective of the vestibular system. Objective: The present study examined vestibular function in patients with frontotemporal dementia (FTD) clinical syndrome and evaluated whether vestibular disor...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2016-05-01
|
| Series: | Dementia and Geriatric Cognitive Disorders Extra |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/445870 |
| _version_ | 1819228327448150016 |
|---|---|
| author | Kiyotaka Nakamagoe Kotarou Kadono Tadachika Koganezawa Mao Takiguchi Makoto Terada Fumiko Yamamoto Tetsuya Moriyama Kumi Yanagiha Seitaro Nohara Naoki Tozaka Zenshi Miyake Satoshi Aizawa Kentaro Furusho Akira Tamaoka |
| author_facet | Kiyotaka Nakamagoe Kotarou Kadono Tadachika Koganezawa Mao Takiguchi Makoto Terada Fumiko Yamamoto Tetsuya Moriyama Kumi Yanagiha Seitaro Nohara Naoki Tozaka Zenshi Miyake Satoshi Aizawa Kentaro Furusho Akira Tamaoka |
| author_sort | Kiyotaka Nakamagoe |
| collection | DOAJ |
| description | Background: No studies to date have attempted to evaluate frontotemporal lobar degeneration from the perspective of the vestibular system. Objective: The present study examined vestibular function in patients with frontotemporal dementia (FTD) clinical syndrome and evaluated whether vestibular disorders are involved in the clinical symptoms due to FTD. Methods: Fourteen patients with FTD syndrome, as well as healthy elderly controls without dementia, were included in the present study. All subjects underwent vestibular function tests using electronystagmography, such as caloric tests and visual suppression (VS) tests, in which the induced caloric nystagmus was suppressed by visual stimuli. The association between clinical symptoms and vestibular function in the FTD syndrome group was further examined. Results: In the FTD syndrome group, caloric nystagmus was not necessarily suppressed during VS tests. Furthermore, VS was observed to be significantly impaired in FTD syndrome patients with gait disturbance as compared to those without such disturbance. Conclusion: The present study revealed that impairment of VS in patients with FTD results in an inability to regulate vestibular function by means of visual perception, regardless of multiple presumed neuropathological backgrounds. This could also be associated with gait disturbance in patients with FTD syndrome. |
| first_indexed | 2024-12-23T10:55:31Z |
| format | Article |
| id | doaj.art-69bc264c04fd40d282f8d17b3785ddb2 |
| institution | Directory Open Access Journal |
| issn | 1664-5464 |
| language | English |
| last_indexed | 2024-12-23T10:55:31Z |
| publishDate | 2016-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dementia and Geriatric Cognitive Disorders Extra |
| spelling | doaj.art-69bc264c04fd40d282f8d17b3785ddb22022-12-21T17:49:47ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642016-05-016219420410.1159/000445870445870Vestibular Impairment in Frontotemporal Dementia SyndromeKiyotaka NakamagoeKotarou KadonoTadachika KoganezawaMao TakiguchiMakoto TeradaFumiko YamamotoTetsuya MoriyamaKumi YanagihaSeitaro NoharaNaoki TozakaZenshi MiyakeSatoshi AizawaKentaro FurushoAkira TamaokaBackground: No studies to date have attempted to evaluate frontotemporal lobar degeneration from the perspective of the vestibular system. Objective: The present study examined vestibular function in patients with frontotemporal dementia (FTD) clinical syndrome and evaluated whether vestibular disorders are involved in the clinical symptoms due to FTD. Methods: Fourteen patients with FTD syndrome, as well as healthy elderly controls without dementia, were included in the present study. All subjects underwent vestibular function tests using electronystagmography, such as caloric tests and visual suppression (VS) tests, in which the induced caloric nystagmus was suppressed by visual stimuli. The association between clinical symptoms and vestibular function in the FTD syndrome group was further examined. Results: In the FTD syndrome group, caloric nystagmus was not necessarily suppressed during VS tests. Furthermore, VS was observed to be significantly impaired in FTD syndrome patients with gait disturbance as compared to those without such disturbance. Conclusion: The present study revealed that impairment of VS in patients with FTD results in an inability to regulate vestibular function by means of visual perception, regardless of multiple presumed neuropathological backgrounds. This could also be associated with gait disturbance in patients with FTD syndrome.http://www.karger.com/Article/FullText/445870Vestibular functionFrontotemporal lobar degenerationVestibular stimulationFrontal eye fieldInferior parietal lobuleCaloric testVisual suppressionFrontotemporal dementia |
| spellingShingle | Kiyotaka Nakamagoe Kotarou Kadono Tadachika Koganezawa Mao Takiguchi Makoto Terada Fumiko Yamamoto Tetsuya Moriyama Kumi Yanagiha Seitaro Nohara Naoki Tozaka Zenshi Miyake Satoshi Aizawa Kentaro Furusho Akira Tamaoka Vestibular Impairment in Frontotemporal Dementia Syndrome Dementia and Geriatric Cognitive Disorders Extra Vestibular function Frontotemporal lobar degeneration Vestibular stimulation Frontal eye field Inferior parietal lobule Caloric test Visual suppression Frontotemporal dementia |
| title | Vestibular Impairment in Frontotemporal Dementia Syndrome |
| title_full | Vestibular Impairment in Frontotemporal Dementia Syndrome |
| title_fullStr | Vestibular Impairment in Frontotemporal Dementia Syndrome |
| title_full_unstemmed | Vestibular Impairment in Frontotemporal Dementia Syndrome |
| title_short | Vestibular Impairment in Frontotemporal Dementia Syndrome |
| title_sort | vestibular impairment in frontotemporal dementia syndrome |
| topic | Vestibular function Frontotemporal lobar degeneration Vestibular stimulation Frontal eye field Inferior parietal lobule Caloric test Visual suppression Frontotemporal dementia |
| url | http://www.karger.com/Article/FullText/445870 |
| work_keys_str_mv | AT kiyotakanakamagoe vestibularimpairmentinfrontotemporaldementiasyndrome AT kotaroukadono vestibularimpairmentinfrontotemporaldementiasyndrome AT tadachikakoganezawa vestibularimpairmentinfrontotemporaldementiasyndrome AT maotakiguchi vestibularimpairmentinfrontotemporaldementiasyndrome AT makototerada vestibularimpairmentinfrontotemporaldementiasyndrome AT fumikoyamamoto vestibularimpairmentinfrontotemporaldementiasyndrome AT tetsuyamoriyama vestibularimpairmentinfrontotemporaldementiasyndrome AT kumiyanagiha vestibularimpairmentinfrontotemporaldementiasyndrome AT seitaronohara vestibularimpairmentinfrontotemporaldementiasyndrome AT naokitozaka vestibularimpairmentinfrontotemporaldementiasyndrome AT zenshimiyake vestibularimpairmentinfrontotemporaldementiasyndrome AT satoshiaizawa vestibularimpairmentinfrontotemporaldementiasyndrome AT kentarofurusho vestibularimpairmentinfrontotemporaldementiasyndrome AT akiratamaoka vestibularimpairmentinfrontotemporaldementiasyndrome |