Pathologic results of stereotactic core needle biopsy in patient with malignancy suspicious to microcalcification on mammography
Introduction: Due to the fact that breast cancer has a high prevalence in the society and in a significant number of patients, its initial manifestation is only in the form of microcalcification on mammography, this study was performed with aim to evaluate the pathologic results of stereotactic cor...
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| Format: | Article |
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Mashhad University of Medical Sciences
2020-08-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_16879_5e4b751ee1a051921f2af3181e3a3bb8.pdf |
| _version_ | 1798044441112477696 |
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| author | Mansoureh Baradaran Donya Farrokh Mona Najaf Najafi Nourieh Sharifi |
| author_facet | Mansoureh Baradaran Donya Farrokh Mona Najaf Najafi Nourieh Sharifi |
| author_sort | Mansoureh Baradaran |
| collection | DOAJ |
| description | Introduction: Due to the fact that breast cancer has a high prevalence in the society and in a significant number of patients, its initial manifestation is only in the form of microcalcification on mammography, this study was performed with aim to evaluate the pathologic results of stereotactic core needle biopsy to determine the prevalence of malignant and benign lesion and subtype in each group in patients with suspicious microcalcifications on mammography based on BIRADS classification.
Methods: In this descriptive study, 59 patients referred to mammographic clinic in Mashhad city between April2017-September2019, and underwent sterotactic core biopsy because of the presence of suspicious microcalcifications (including morphology and distribution) without mass or focal asymmetry on mammography. In all patients, calcification was identified in at least one core needle specimen after performing specimen mammography. The specimens were submitted and referred to pathologic laboratory and analyzed by two pathologists. The total prevalence of benign and malignant lesions and also the prevalence of subtype lesions in each group were evaluated. The results of different mammographic appearance of suspicious microcalcifications were also compared with pathologic diagnosis. Data were analyzed using SPSS statistical software (version 16) and descriptive statistics methods and frequency distribution of variables in the form of tables. P<0.05 was considered statistically significant.
Results: Benign lesions were seen in 42 patients (71%) and malignant lesions in 17 patients (29%) in histopathologic examination. Total prevalence of benign lesions was more than malignant lesions and the prevalence of non-proliferative lesions more than proliferative lesions. Fibrocystic change was the most common lesion in non-proliferative group (54%). In malignant group, prevalence of Dcis Carcinoma and invasive ductal carcinoma was 74% and 26%, respectively. Prevalence of malignancy was more in pleomorphic type of microcalcifications than amorphous and coarse heterogeneous types.
Conclusion: According to the significant prevalence of malignancy especially the prevalence of DCIS, sterotactic biopsy can be used as a noninvasive biopsy method for Microcalcifications which have a suspicious morphology and distribution to detect early breast cancer. |
| first_indexed | 2024-04-11T23:03:46Z |
| format | Article |
| id | doaj.art-69bd230768a84c708faf32c3d87f4cd0 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-11T23:03:46Z |
| publishDate | 2020-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-69bd230768a84c708faf32c3d87f4cd02022-12-22T03:58:04ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632020-08-01236435010.22038/ijogi.2020.1687916879Pathologic results of stereotactic core needle biopsy in patient with malignancy suspicious to microcalcification on mammographyMansoureh Baradaran0Donya Farrokh1Mona Najaf Najafi2Nourieh Sharifi3Resident, Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Associate Professor, Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Assistant Professor, Department of Community Medicine, Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: Due to the fact that breast cancer has a high prevalence in the society and in a significant number of patients, its initial manifestation is only in the form of microcalcification on mammography, this study was performed with aim to evaluate the pathologic results of stereotactic core needle biopsy to determine the prevalence of malignant and benign lesion and subtype in each group in patients with suspicious microcalcifications on mammography based on BIRADS classification. Methods: In this descriptive study, 59 patients referred to mammographic clinic in Mashhad city between April2017-September2019, and underwent sterotactic core biopsy because of the presence of suspicious microcalcifications (including morphology and distribution) without mass or focal asymmetry on mammography. In all patients, calcification was identified in at least one core needle specimen after performing specimen mammography. The specimens were submitted and referred to pathologic laboratory and analyzed by two pathologists. The total prevalence of benign and malignant lesions and also the prevalence of subtype lesions in each group were evaluated. The results of different mammographic appearance of suspicious microcalcifications were also compared with pathologic diagnosis. Data were analyzed using SPSS statistical software (version 16) and descriptive statistics methods and frequency distribution of variables in the form of tables. P<0.05 was considered statistically significant. Results: Benign lesions were seen in 42 patients (71%) and malignant lesions in 17 patients (29%) in histopathologic examination. Total prevalence of benign lesions was more than malignant lesions and the prevalence of non-proliferative lesions more than proliferative lesions. Fibrocystic change was the most common lesion in non-proliferative group (54%). In malignant group, prevalence of Dcis Carcinoma and invasive ductal carcinoma was 74% and 26%, respectively. Prevalence of malignancy was more in pleomorphic type of microcalcifications than amorphous and coarse heterogeneous types. Conclusion: According to the significant prevalence of malignancy especially the prevalence of DCIS, sterotactic biopsy can be used as a noninvasive biopsy method for Microcalcifications which have a suspicious morphology and distribution to detect early breast cancer.https://ijogi.mums.ac.ir/article_16879_5e4b751ee1a051921f2af3181e3a3bb8.pdfbreast biopsycalcificationmammography |
| spellingShingle | Mansoureh Baradaran Donya Farrokh Mona Najaf Najafi Nourieh Sharifi Pathologic results of stereotactic core needle biopsy in patient with malignancy suspicious to microcalcification on mammography Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān breast biopsy calcification mammography |
| title | Pathologic results of stereotactic core needle biopsy in patient with malignancy suspicious to microcalcification on mammography |
| title_full | Pathologic results of stereotactic core needle biopsy in patient with malignancy suspicious to microcalcification on mammography |
| title_fullStr | Pathologic results of stereotactic core needle biopsy in patient with malignancy suspicious to microcalcification on mammography |
| title_full_unstemmed | Pathologic results of stereotactic core needle biopsy in patient with malignancy suspicious to microcalcification on mammography |
| title_short | Pathologic results of stereotactic core needle biopsy in patient with malignancy suspicious to microcalcification on mammography |
| title_sort | pathologic results of stereotactic core needle biopsy in patient with malignancy suspicious to microcalcification on mammography |
| topic | breast biopsy calcification mammography |
| url | https://ijogi.mums.ac.ir/article_16879_5e4b751ee1a051921f2af3181e3a3bb8.pdf |
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