Use of Sertraline in Hemodialysis Patients
Depression and anxiety are the most common psychiatric disorders in end-stage renal disease (ESRD) patients treated with hemodialysis (HD) and may correlate with lower quality of life and increased mortality. Depression treatment in HD patients is still a challenge both for nephrologists and psychia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/9/949 |
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| author | Alicja Kubanek Przemysław Paul Mateusz Przybylak Katarzyna Kanclerz Jakub Jan Rojek Marcin Renke Leszek Bidzan Jakub Grabowski |
| author_facet | Alicja Kubanek Przemysław Paul Mateusz Przybylak Katarzyna Kanclerz Jakub Jan Rojek Marcin Renke Leszek Bidzan Jakub Grabowski |
| author_sort | Alicja Kubanek |
| collection | DOAJ |
| description | Depression and anxiety are the most common psychiatric disorders in end-stage renal disease (ESRD) patients treated with hemodialysis (HD) and may correlate with lower quality of life and increased mortality. Depression treatment in HD patients is still a challenge both for nephrologists and psychiatrists. The possible treatment of depressive disorders can be pharmacological and non-pharmacological. In our article, we focus on the use of sertraline, the medication which seems to be relatively safe and efficient in the abovementioned population, taking under consideration several limitations regarding the use of other selective serotonin reuptake inhibitors (SSRIs). In our paper, we discuss different aspects of sertraline use, taking into consideration possible benefits and side effects of drug administration like impact on QTc (corrected QT interval) prolongation, intradialytic hypotension (IDH), chronic kidney disease-associated pruritus (CKD-aP), bleeding, sexual functions, inflammation, or fracture risk. Before administering the medication, one should consider benefits and possible side effects, which are particularly significant in the treatment of ESRD patients; this could help to optimize clinical outcomes. Sertraline seems to be safe in the HD population when provided in proper doses. However, we still need more studies in this field since the ones performed so far were usually based on small samples and lacked placebo control. |
| first_indexed | 2024-03-10T07:28:01Z |
| format | Article |
| id | doaj.art-69bd95716b334d71bb02e5491d016dfb |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T07:28:01Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-69bd95716b334d71bb02e5491d016dfb2023-11-22T14:08:46ZengMDPI AGMedicina1010-660X1648-91442021-09-0157994910.3390/medicina57090949Use of Sertraline in Hemodialysis PatientsAlicja Kubanek0Przemysław Paul1Mateusz Przybylak2Katarzyna Kanclerz3Jakub Jan Rojek4Marcin Renke5Leszek Bidzan6Jakub Grabowski7Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdańsk, 81-519 Gdynia, PolandDepartment of Occupational, Metabolic and Internal Diseases, Medical University of Gdańsk, 81-519 Gdynia, PolandDepartment of Developmental Psychiatry, Psychotic and Geriatric Disorders, Medical University of Gdansk, 80-282 Gdańsk, PolandDepartment of Occupational, Metabolic and Internal Diseases, Medical University of Gdańsk, 81-519 Gdynia, PolandAdult Psychiatry Scientific Circle, Department of Developmental Psychiatry, Psychotic and Geriatric Disorders, Medical University of Gdansk, 80-282 Gdańsk, PolandDepartment of Occupational, Metabolic and Internal Diseases, Medical University of Gdańsk, 81-519 Gdynia, PolandDepartment of Developmental Psychiatry, Psychotic and Geriatric Disorders, Medical University of Gdansk, 80-282 Gdańsk, PolandDepartment of Developmental Psychiatry, Psychotic and Geriatric Disorders, Medical University of Gdansk, 80-282 Gdańsk, PolandDepression and anxiety are the most common psychiatric disorders in end-stage renal disease (ESRD) patients treated with hemodialysis (HD) and may correlate with lower quality of life and increased mortality. Depression treatment in HD patients is still a challenge both for nephrologists and psychiatrists. The possible treatment of depressive disorders can be pharmacological and non-pharmacological. In our article, we focus on the use of sertraline, the medication which seems to be relatively safe and efficient in the abovementioned population, taking under consideration several limitations regarding the use of other selective serotonin reuptake inhibitors (SSRIs). In our paper, we discuss different aspects of sertraline use, taking into consideration possible benefits and side effects of drug administration like impact on QTc (corrected QT interval) prolongation, intradialytic hypotension (IDH), chronic kidney disease-associated pruritus (CKD-aP), bleeding, sexual functions, inflammation, or fracture risk. Before administering the medication, one should consider benefits and possible side effects, which are particularly significant in the treatment of ESRD patients; this could help to optimize clinical outcomes. Sertraline seems to be safe in the HD population when provided in proper doses. However, we still need more studies in this field since the ones performed so far were usually based on small samples and lacked placebo control.https://www.mdpi.com/1648-9144/57/9/949depressionhemodialysissertraline |
| spellingShingle | Alicja Kubanek Przemysław Paul Mateusz Przybylak Katarzyna Kanclerz Jakub Jan Rojek Marcin Renke Leszek Bidzan Jakub Grabowski Use of Sertraline in Hemodialysis Patients Medicina depression hemodialysis sertraline |
| title | Use of Sertraline in Hemodialysis Patients |
| title_full | Use of Sertraline in Hemodialysis Patients |
| title_fullStr | Use of Sertraline in Hemodialysis Patients |
| title_full_unstemmed | Use of Sertraline in Hemodialysis Patients |
| title_short | Use of Sertraline in Hemodialysis Patients |
| title_sort | use of sertraline in hemodialysis patients |
| topic | depression hemodialysis sertraline |
| url | https://www.mdpi.com/1648-9144/57/9/949 |
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