Curcumin Inhibits The Adverse Effects of Sodium Arsenite in Mouse Epididymal Sperm
Background The aim of this study was to investigate the effects of curcumin on epididy- mal sperm parameters in adult male Navel Medical Research Institute (NMRI) mice ex- posed to sodium arsenite. Materials and Methods In this experimental study, we divided the animals into four groups: control, so...
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| Format: | Article |
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Royan Institute (ACECR), Tehran
2016-07-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | http://www.ijfs.ir/article_45385_a3852a5b4a300d672246d1b66f5eff7a.pdf |
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| author | Hamid Reza Momeni Najmeh Eskandari |
| author_facet | Hamid Reza Momeni Najmeh Eskandari |
| author_sort | Hamid Reza Momeni |
| collection | DOAJ |
| description | Background The aim of this study was to investigate the effects of curcumin on epididy- mal sperm parameters in adult male Navel Medical Research Institute (NMRI) mice ex- posed to sodium arsenite. Materials and Methods In this experimental study, we divided the animals into four groups: control, sodium arsenite (5 mg/kg), curcumin (100 mg/kg) and curcumin+sodium arsenite. Exposures were performed by intraperitoneal injections for a 5-week period. After the exposure period, we recorded the animals’ body and left testes weights. The left caudal epididymis was used to count the sperm number and analyze motility, viability, morphological abnormalities, acrosome reaction, DNA integrity, and histone-protamine replacement in the spermatozoa. One-way analysis of variance (ANOVA) followed by the Tukey’s test was used to assess the statistical significance of the data with SPSS 16.0. P < 0.05 was considered significant. Results Mice exposed to sodium arsenite showed a significant decrease in the num- ber, motility, viability, normal sperm morphology and acrosome integrity of spermato- zoa compared to the control group. In the curcumin+sodium arsenite group, curcumin significantly reversed these adverse effects to the point where they approximated the control. In addition, the application of curcumin alone had no significant difference in these parameters compared to the control and curcumin+sodium arsenite groups. However, we observed no significant differences in the body and the testis weight as well as the DNA integrity and histone-protamine replacement in the spermatozoa of the four groups. Conclusion Curcumin compensated for the toxic effects of sodium arsenite on a number of sperm parameters in adult mice. |
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| format | Article |
| id | doaj.art-69bee52f0b5a46f78add0af31e3b4d4b |
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| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-04-13T05:14:39Z |
| publishDate | 2016-07-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-69bee52f0b5a46f78add0af31e3b4d4b2022-12-22T03:00:55ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782016-07-0110224525210.22074/ijfs.2016.491645385Curcumin Inhibits The Adverse Effects of Sodium Arsenite in Mouse Epididymal SpermHamid Reza Momeni0Najmeh Eskandari1Department of Biology, Faculty of Science, Arak University, Arak, IranDepartment of Biology, Faculty of Science, Arak University, Arak, IranBackground The aim of this study was to investigate the effects of curcumin on epididy- mal sperm parameters in adult male Navel Medical Research Institute (NMRI) mice ex- posed to sodium arsenite. Materials and Methods In this experimental study, we divided the animals into four groups: control, sodium arsenite (5 mg/kg), curcumin (100 mg/kg) and curcumin+sodium arsenite. Exposures were performed by intraperitoneal injections for a 5-week period. After the exposure period, we recorded the animals’ body and left testes weights. The left caudal epididymis was used to count the sperm number and analyze motility, viability, morphological abnormalities, acrosome reaction, DNA integrity, and histone-protamine replacement in the spermatozoa. One-way analysis of variance (ANOVA) followed by the Tukey’s test was used to assess the statistical significance of the data with SPSS 16.0. P < 0.05 was considered significant. Results Mice exposed to sodium arsenite showed a significant decrease in the num- ber, motility, viability, normal sperm morphology and acrosome integrity of spermato- zoa compared to the control group. In the curcumin+sodium arsenite group, curcumin significantly reversed these adverse effects to the point where they approximated the control. In addition, the application of curcumin alone had no significant difference in these parameters compared to the control and curcumin+sodium arsenite groups. However, we observed no significant differences in the body and the testis weight as well as the DNA integrity and histone-protamine replacement in the spermatozoa of the four groups. Conclusion Curcumin compensated for the toxic effects of sodium arsenite on a number of sperm parameters in adult mice.http://www.ijfs.ir/article_45385_a3852a5b4a300d672246d1b66f5eff7a.pdfcurcuminnatural antioxidantsodium arsenite |
| spellingShingle | Hamid Reza Momeni Najmeh Eskandari Curcumin Inhibits The Adverse Effects of Sodium Arsenite in Mouse Epididymal Sperm International Journal of Fertility and Sterility curcumin natural antioxidant sodium arsenite |
| title | Curcumin Inhibits The Adverse Effects of Sodium Arsenite in Mouse Epididymal Sperm |
| title_full | Curcumin Inhibits The Adverse Effects of Sodium Arsenite in Mouse Epididymal Sperm |
| title_fullStr | Curcumin Inhibits The Adverse Effects of Sodium Arsenite in Mouse Epididymal Sperm |
| title_full_unstemmed | Curcumin Inhibits The Adverse Effects of Sodium Arsenite in Mouse Epididymal Sperm |
| title_short | Curcumin Inhibits The Adverse Effects of Sodium Arsenite in Mouse Epididymal Sperm |
| title_sort | curcumin inhibits the adverse effects of sodium arsenite in mouse epididymal sperm |
| topic | curcumin natural antioxidant sodium arsenite |
| url | http://www.ijfs.ir/article_45385_a3852a5b4a300d672246d1b66f5eff7a.pdf |
| work_keys_str_mv | AT hamidrezamomeni curcumininhibitstheadverseeffectsofsodiumarseniteinmouseepididymalsperm AT najmeheskandari curcumininhibitstheadverseeffectsofsodiumarseniteinmouseepididymalsperm |