Hydrothermally Synthesized Hydroxyapatite-Silica Composites with Enhanced Mechanical Properties for Bone Graft Applications
The demand for synthetic bone grafts has increased in recent years. Hydroxyapatite (HA) is one of the highly suitable candidates as a bone graft material due to its excellent biocompatibility and high osteoconductive properties with low toxicity. HA has disadvantageous mechanical strength showing re...
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MDPI AG
2023-07-01
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| Series: | Chemistry |
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| Online Access: | https://www.mdpi.com/2624-8549/5/3/113 |
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| author | Atiek Rostika Noviyanti Juliandri Juliandri Engela Evy Ernawati Haryono Haryono Solihudin Solihudin Dina Dwiyanti Azman Ma’amor Ferli Septi Irwansyah Sharifuddin Bin Md Zain |
| author_facet | Atiek Rostika Noviyanti Juliandri Juliandri Engela Evy Ernawati Haryono Haryono Solihudin Solihudin Dina Dwiyanti Azman Ma’amor Ferli Septi Irwansyah Sharifuddin Bin Md Zain |
| author_sort | Atiek Rostika Noviyanti |
| collection | DOAJ |
| description | The demand for synthetic bone grafts has increased in recent years. Hydroxyapatite (HA) is one of the highly suitable candidates as a bone graft material due to its excellent biocompatibility and high osteoconductive properties with low toxicity. HA has disadvantageous mechanical strength showing relatively fragile and brittle behavior due to its high hygroscopic properties. This leads to improper mechanical properties for such grafting applications. Therefore, HA should be combined with another material with similar biocompatibility and high hardness, such as SiO<sub>2</sub>. In this work, HA/SiO<sub>2</sub> (HAS) composite material was prepared via a hydrothermal method to obtain the high purities of HA with a particle size of approximately 35 nm and around 50% crystallinity. It was found that the addition of SiO<sub>2</sub> stimulated the composite system by forming an orthosilicic acid complex that can reduce the overall solution’s pH, thus contributing to the integrity and stability of the HAS composite. Therefore, higher SiO<sub>2</sub> contents in the HAS composite can enhance its mechanical stability when immersed in simulated body fluid (SBF). Our work demonstrated that HAS can highly improve HA material’s hardness and mechanical stability under immersion of SBF. The Vickers test showed that the 0.05 GPa hardness in 10% SiO<sub>2</sub> increased to 0.35 GPa hardness with the addition of 20% SiO<sub>2</sub>. The crystal structures of HAS were analyzed using X-ray diffraction, and the morphology of the HAS composites was observed under electron microscopy. |
| first_indexed | 2024-03-10T22:55:17Z |
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| issn | 2624-8549 |
| language | English |
| last_indexed | 2024-03-10T22:55:17Z |
| publishDate | 2023-07-01 |
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| record_format | Article |
| series | Chemistry |
| spelling | doaj.art-69bfd340473d4ca3bcc8a2bc2e0b672d2023-11-19T10:01:23ZengMDPI AGChemistry2624-85492023-07-01531645165510.3390/chemistry5030113Hydrothermally Synthesized Hydroxyapatite-Silica Composites with Enhanced Mechanical Properties for Bone Graft ApplicationsAtiek Rostika Noviyanti0Juliandri Juliandri1Engela Evy Ernawati2Haryono Haryono3Solihudin Solihudin4Dina Dwiyanti5Azman Ma’amor6Ferli Septi Irwansyah7Sharifuddin Bin Md Zain8Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartement of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 56000, MalaysiaDepartement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartement of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 56000, MalaysiaThe demand for synthetic bone grafts has increased in recent years. Hydroxyapatite (HA) is one of the highly suitable candidates as a bone graft material due to its excellent biocompatibility and high osteoconductive properties with low toxicity. HA has disadvantageous mechanical strength showing relatively fragile and brittle behavior due to its high hygroscopic properties. This leads to improper mechanical properties for such grafting applications. Therefore, HA should be combined with another material with similar biocompatibility and high hardness, such as SiO<sub>2</sub>. In this work, HA/SiO<sub>2</sub> (HAS) composite material was prepared via a hydrothermal method to obtain the high purities of HA with a particle size of approximately 35 nm and around 50% crystallinity. It was found that the addition of SiO<sub>2</sub> stimulated the composite system by forming an orthosilicic acid complex that can reduce the overall solution’s pH, thus contributing to the integrity and stability of the HAS composite. Therefore, higher SiO<sub>2</sub> contents in the HAS composite can enhance its mechanical stability when immersed in simulated body fluid (SBF). Our work demonstrated that HAS can highly improve HA material’s hardness and mechanical stability under immersion of SBF. The Vickers test showed that the 0.05 GPa hardness in 10% SiO<sub>2</sub> increased to 0.35 GPa hardness with the addition of 20% SiO<sub>2</sub>. The crystal structures of HAS were analyzed using X-ray diffraction, and the morphology of the HAS composites was observed under electron microscopy.https://www.mdpi.com/2624-8549/5/3/113hydroxyapatite-silica compositehydrothermal methodsimulated body fluidhighly stable mechanical properties |
| spellingShingle | Atiek Rostika Noviyanti Juliandri Juliandri Engela Evy Ernawati Haryono Haryono Solihudin Solihudin Dina Dwiyanti Azman Ma’amor Ferli Septi Irwansyah Sharifuddin Bin Md Zain Hydrothermally Synthesized Hydroxyapatite-Silica Composites with Enhanced Mechanical Properties for Bone Graft Applications Chemistry hydroxyapatite-silica composite hydrothermal method simulated body fluid highly stable mechanical properties |
| title | Hydrothermally Synthesized Hydroxyapatite-Silica Composites with Enhanced Mechanical Properties for Bone Graft Applications |
| title_full | Hydrothermally Synthesized Hydroxyapatite-Silica Composites with Enhanced Mechanical Properties for Bone Graft Applications |
| title_fullStr | Hydrothermally Synthesized Hydroxyapatite-Silica Composites with Enhanced Mechanical Properties for Bone Graft Applications |
| title_full_unstemmed | Hydrothermally Synthesized Hydroxyapatite-Silica Composites with Enhanced Mechanical Properties for Bone Graft Applications |
| title_short | Hydrothermally Synthesized Hydroxyapatite-Silica Composites with Enhanced Mechanical Properties for Bone Graft Applications |
| title_sort | hydrothermally synthesized hydroxyapatite silica composites with enhanced mechanical properties for bone graft applications |
| topic | hydroxyapatite-silica composite hydrothermal method simulated body fluid highly stable mechanical properties |
| url | https://www.mdpi.com/2624-8549/5/3/113 |
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