Downregulation of PI3K/AKT/mTOR Pathway in Juglone-Treated Bovine Oocytes

Downregulation of PI3K/AKT/mTOR Pathway in Juglone-Treated Bovine Oocytes

We have previously reported that juglone, a natural compound found in Juglandaceae with a wide range of biological activities, can reduces the developmental competence of bovine oocytes. In the current study, we investigated the possible mechanisms behind the toxicity of juglone and the relationship...

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Bibliographic Details
Main Authors: Marwa El-Sheikh, Ayman Mesalam, Atif Ali Khan Khalil, Muhammad Idrees, Mi-Jeong Ahn, Ahmed Atef Mesalam, Il-Keun Kong
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antioxidants
Subjects:
juglone
oocyte quality
histone methylation
PI3K
AKT
mTOR
Online Access:https://www.mdpi.com/2076-3921/12/1/114

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