Enhancing tumor specific immune responses by transcutaneous vaccination
Introduction: Our understanding of the involvement of the immune system in cancer control has increased over recent years. However, the development of cancer vaccines intended to reverse tumor-induced immune tolerance remains slow as most current vaccine candidates exhibit limited clinical efficacy....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-11-01
|
| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14760584.2017.1382357 |
| _version_ | 1797680418128920576 |
|---|---|
| author | Hanadi Saliba Béatrice Heurtault Hasnaa Bouharoun-Tayoun Vincent Flacher Benoît Frisch Sylvie Fournel Soulaima Chamat |
| author_facet | Hanadi Saliba Béatrice Heurtault Hasnaa Bouharoun-Tayoun Vincent Flacher Benoît Frisch Sylvie Fournel Soulaima Chamat |
| author_sort | Hanadi Saliba |
| collection | DOAJ |
| description | Introduction: Our understanding of the involvement of the immune system in cancer control has increased over recent years. However, the development of cancer vaccines intended to reverse tumor-induced immune tolerance remains slow as most current vaccine candidates exhibit limited clinical efficacy. The skin is particularly rich with multiple subsets of dendritic cells (DCs) that are involved to varying degrees in the induction of robust immune responses. Transcutaneous administration of cancer vaccines may therefore harness the immune potential of these DCs, however, this approach is hampered by the impermeability of the stratum corneum. Innovative vaccine formulations including various nanoparticles, such as liposomes, are therefore needed to properly deliver cancer vaccine components to skin DCs. Areas covered: The recent insights into skin DC subsets and their functional specialization, the potential of nanoparticle-based vaccines in transcutaneous cancer vaccination and, finally, the most relevant clinical trial advances in liposomal and in cutaneous cancer vaccines will be discussed. Expert commentary: To define the optimal conditions for mounting protective skin DC-induced anti-tumor immune responses, investigation of the cellular and molecular interplay that controls tumor progression should be pursued in parallel with clinical development. The resulting knowledge will then be translated into improved cancer vaccines that better target the most appropriate immune players. |
| first_indexed | 2024-03-11T23:29:44Z |
| format | Article |
| id | doaj.art-69c1546f4b4b49bf8f3da91e9481dc73 |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:29:44Z |
| publishDate | 2017-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-69c1546f4b4b49bf8f3da91e9481dc732023-09-20T10:18:02ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952017-11-0116111079109410.1080/14760584.2017.13823571382357Enhancing tumor specific immune responses by transcutaneous vaccinationHanadi Saliba0Béatrice Heurtault1Hasnaa Bouharoun-Tayoun2Vincent Flacher3Benoît Frisch4Sylvie Fournel5Soulaima Chamat6University of StrasbourgUniversity of StrasbourgLebanese UniversityInstitut de Biologie Moléculaire et CellulaireUniversity of StrasbourgUniversity of StrasbourgLebanese UniversityIntroduction: Our understanding of the involvement of the immune system in cancer control has increased over recent years. However, the development of cancer vaccines intended to reverse tumor-induced immune tolerance remains slow as most current vaccine candidates exhibit limited clinical efficacy. The skin is particularly rich with multiple subsets of dendritic cells (DCs) that are involved to varying degrees in the induction of robust immune responses. Transcutaneous administration of cancer vaccines may therefore harness the immune potential of these DCs, however, this approach is hampered by the impermeability of the stratum corneum. Innovative vaccine formulations including various nanoparticles, such as liposomes, are therefore needed to properly deliver cancer vaccine components to skin DCs. Areas covered: The recent insights into skin DC subsets and their functional specialization, the potential of nanoparticle-based vaccines in transcutaneous cancer vaccination and, finally, the most relevant clinical trial advances in liposomal and in cutaneous cancer vaccines will be discussed. Expert commentary: To define the optimal conditions for mounting protective skin DC-induced anti-tumor immune responses, investigation of the cellular and molecular interplay that controls tumor progression should be pursued in parallel with clinical development. The resulting knowledge will then be translated into improved cancer vaccines that better target the most appropriate immune players.http://dx.doi.org/10.1080/14760584.2017.1382357cancer vaccineliposomenanoparticleskin dendritic celltranscutaneous vaccination |
| spellingShingle | Hanadi Saliba Béatrice Heurtault Hasnaa Bouharoun-Tayoun Vincent Flacher Benoît Frisch Sylvie Fournel Soulaima Chamat Enhancing tumor specific immune responses by transcutaneous vaccination Expert Review of Vaccines cancer vaccine liposome nanoparticle skin dendritic cell transcutaneous vaccination |
| title | Enhancing tumor specific immune responses by transcutaneous vaccination |
| title_full | Enhancing tumor specific immune responses by transcutaneous vaccination |
| title_fullStr | Enhancing tumor specific immune responses by transcutaneous vaccination |
| title_full_unstemmed | Enhancing tumor specific immune responses by transcutaneous vaccination |
| title_short | Enhancing tumor specific immune responses by transcutaneous vaccination |
| title_sort | enhancing tumor specific immune responses by transcutaneous vaccination |
| topic | cancer vaccine liposome nanoparticle skin dendritic cell transcutaneous vaccination |
| url | http://dx.doi.org/10.1080/14760584.2017.1382357 |
| work_keys_str_mv | AT hanadisaliba enhancingtumorspecificimmuneresponsesbytranscutaneousvaccination AT beatriceheurtault enhancingtumorspecificimmuneresponsesbytranscutaneousvaccination AT hasnaabouharountayoun enhancingtumorspecificimmuneresponsesbytranscutaneousvaccination AT vincentflacher enhancingtumorspecificimmuneresponsesbytranscutaneousvaccination AT benoitfrisch enhancingtumorspecificimmuneresponsesbytranscutaneousvaccination AT sylviefournel enhancingtumorspecificimmuneresponsesbytranscutaneousvaccination AT soulaimachamat enhancingtumorspecificimmuneresponsesbytranscutaneousvaccination |