Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies
Exposure to various forms of arsenic (As), the source of which may be environmental as well as occupational exposure, is associated with many adverse health effects. Therefore, methods to reduce the adverse effects of As on the human body are being sought. Research in this area focuses, among other...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/9/10/259 |
| _version_ | 1827678526998839296 |
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| author | Monika Sijko Lucyna Kozłowska |
| author_facet | Monika Sijko Lucyna Kozłowska |
| author_sort | Monika Sijko |
| collection | DOAJ |
| description | Exposure to various forms of arsenic (As), the source of which may be environmental as well as occupational exposure, is associated with many adverse health effects. Therefore, methods to reduce the adverse effects of As on the human body are being sought. Research in this area focuses, among other topics, on the dietary compounds that are involved in the metabolism of this element. Therefore, the aim of this review was to analyze the influence of methionine, betaine, choline, folic acid, vitamin B<sub>2</sub>, B<sub>6</sub>, B<sub>12</sub> and zinc on the efficiency of inorganic As (iAs) metabolism and the reduction in the severity of the whole spectrum of disorders related to As exposure. In this review, which included 62 original papers (human studies) we present the current knowledge in the area. In human studies, these compounds (methionine, choline, folic acid, vitamin B<sub>2</sub>, B<sub>6</sub>, B<sub>12</sub> and zinc) may increase iAs metabolism and reduce toxicity, whereas their deficiency may impair iAs metabolism and increase As toxicity. Taking into account the results of studies conducted in populations exposed to As, it is reasonable to carry out prophylactic activities. In particular nutritional education seems to be important and should be focused on informing people that an adequate intake of those dietary compounds potentially has a modulating effect on iAs metabolism, thus, reducing its adverse effects on the body. |
| first_indexed | 2024-03-10T06:10:26Z |
| format | Article |
| id | doaj.art-69c583d0b0ae44408b3297e5c0d01297 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T06:10:26Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-69c583d0b0ae44408b3297e5c0d012972023-11-22T20:12:33ZengMDPI AGToxics2305-63042021-10-0191025910.3390/toxics9100259Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human StudiesMonika Sijko0Lucyna Kozłowska1Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), 159c Nowoursynowska Street, 02-776 Warsaw, PolandDepartment of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), 159c Nowoursynowska Street, 02-776 Warsaw, PolandExposure to various forms of arsenic (As), the source of which may be environmental as well as occupational exposure, is associated with many adverse health effects. Therefore, methods to reduce the adverse effects of As on the human body are being sought. Research in this area focuses, among other topics, on the dietary compounds that are involved in the metabolism of this element. Therefore, the aim of this review was to analyze the influence of methionine, betaine, choline, folic acid, vitamin B<sub>2</sub>, B<sub>6</sub>, B<sub>12</sub> and zinc on the efficiency of inorganic As (iAs) metabolism and the reduction in the severity of the whole spectrum of disorders related to As exposure. In this review, which included 62 original papers (human studies) we present the current knowledge in the area. In human studies, these compounds (methionine, choline, folic acid, vitamin B<sub>2</sub>, B<sub>6</sub>, B<sub>12</sub> and zinc) may increase iAs metabolism and reduce toxicity, whereas their deficiency may impair iAs metabolism and increase As toxicity. Taking into account the results of studies conducted in populations exposed to As, it is reasonable to carry out prophylactic activities. In particular nutritional education seems to be important and should be focused on informing people that an adequate intake of those dietary compounds potentially has a modulating effect on iAs metabolism, thus, reducing its adverse effects on the body.https://www.mdpi.com/2305-6304/9/10/259vitaminsmineralsinorganic arsenicexposuredetoxificationmetal toxicity |
| spellingShingle | Monika Sijko Lucyna Kozłowska Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies Toxics vitamins minerals inorganic arsenic exposure detoxification metal toxicity |
| title | Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies |
| title_full | Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies |
| title_fullStr | Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies |
| title_full_unstemmed | Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies |
| title_short | Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies |
| title_sort | influence of dietary compounds on arsenic metabolism and toxicity part ii human studies |
| topic | vitamins minerals inorganic arsenic exposure detoxification metal toxicity |
| url | https://www.mdpi.com/2305-6304/9/10/259 |
| work_keys_str_mv | AT monikasijko influenceofdietarycompoundsonarsenicmetabolismandtoxicitypartiihumanstudies AT lucynakozłowska influenceofdietarycompoundsonarsenicmetabolismandtoxicitypartiihumanstudies |