Neoantigen cancer vaccines: a new star on the horizon
Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient’s own immune system and eliminate cancer cells. One of the most exciting advances within this field is the targeting of neoantigens, which are peptides derived from non-syno...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
China Anti-Cancer Association
2024-04-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | https://www.cancerbiomed.org/content/21/4/274 |
| _version_ | 1797198574378811392 |
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| author | Xiaoling Li Jian You Liping Hong Weijiang Liu Peng Guo Xishan Hao |
| author_facet | Xiaoling Li Jian You Liping Hong Weijiang Liu Peng Guo Xishan Hao |
| author_sort | Xiaoling Li |
| collection | DOAJ |
| description | Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient’s own immune system and eliminate cancer cells. One of the most exciting advances within this field is the targeting of neoantigens, which are peptides derived from non-synonymous somatic mutations that are found exclusively within cancer cells and absent in normal cells. Although neoantigen-based therapeutic vaccines have not received approval for standard cancer treatment, early clinical trials have yielded encouraging outcomes as standalone monotherapy or when combined with checkpoint inhibitors. Progress made in high-throughput sequencing and bioinformatics have greatly facilitated the precise and efficient identification of neoantigens. Consequently, personalized neoantigen-based vaccines tailored to each patient have been developed that are capable of eliciting a robust and long-lasting immune response which effectively eliminates tumors and prevents recurrences. This review provides a concise overview consolidating the latest clinical advances in neoantigen-based therapeutic vaccines, and also discusses challenges and future perspectives for this innovative approach, particularly emphasizing the potential of neoantigen-based therapeutic vaccines to enhance clinical efficacy against advanced solid tumors. |
| first_indexed | 2024-04-24T07:02:01Z |
| format | Article |
| id | doaj.art-69c77fca518842848a2e37416ef925c3 |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-04-24T07:02:01Z |
| publishDate | 2024-04-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-69c77fca518842848a2e37416ef925c32024-04-22T08:09:04ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412024-04-0121427431110.20892/j.issn.2095-3941.2023.0395Neoantigen cancer vaccines: a new star on the horizonXiaoling Li0Jian You1Liping Hong2Weijiang Liu3Peng Guo4Xishan Hao5Cell Biotechnology Laboratory, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, ChinaDepartment of Thoracic Oncology, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, ChinaCell Biotechnology Laboratory, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, ChinaCell Biotechnology Laboratory, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, ChinaCell Biotechnology Laboratory, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, ChinaCell Biotechnology Laboratory, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, ChinaImmunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient’s own immune system and eliminate cancer cells. One of the most exciting advances within this field is the targeting of neoantigens, which are peptides derived from non-synonymous somatic mutations that are found exclusively within cancer cells and absent in normal cells. Although neoantigen-based therapeutic vaccines have not received approval for standard cancer treatment, early clinical trials have yielded encouraging outcomes as standalone monotherapy or when combined with checkpoint inhibitors. Progress made in high-throughput sequencing and bioinformatics have greatly facilitated the precise and efficient identification of neoantigens. Consequently, personalized neoantigen-based vaccines tailored to each patient have been developed that are capable of eliciting a robust and long-lasting immune response which effectively eliminates tumors and prevents recurrences. This review provides a concise overview consolidating the latest clinical advances in neoantigen-based therapeutic vaccines, and also discusses challenges and future perspectives for this innovative approach, particularly emphasizing the potential of neoantigen-based therapeutic vaccines to enhance clinical efficacy against advanced solid tumors.https://www.cancerbiomed.org/content/21/4/274immunotherapyneoantigen cancer vaccinesolid tumorshigh-throughput sequencingbioinformaticspdosaihlatcr |
| spellingShingle | Xiaoling Li Jian You Liping Hong Weijiang Liu Peng Guo Xishan Hao Neoantigen cancer vaccines: a new star on the horizon Cancer Biology & Medicine immunotherapy neoantigen cancer vaccine solid tumors high-throughput sequencing bioinformatics pdos ai hla tcr |
| title | Neoantigen cancer vaccines: a new star on the horizon |
| title_full | Neoantigen cancer vaccines: a new star on the horizon |
| title_fullStr | Neoantigen cancer vaccines: a new star on the horizon |
| title_full_unstemmed | Neoantigen cancer vaccines: a new star on the horizon |
| title_short | Neoantigen cancer vaccines: a new star on the horizon |
| title_sort | neoantigen cancer vaccines a new star on the horizon |
| topic | immunotherapy neoantigen cancer vaccine solid tumors high-throughput sequencing bioinformatics pdos ai hla tcr |
| url | https://www.cancerbiomed.org/content/21/4/274 |
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