Nonalcoholic Fatty Liver Disease and the Kidney: A Review
Nonalcoholic fatty liver disease (NAFLD) is associated with several extrahepatic manifestations such as cardiovascular disease and sleep apnea. Furthermore, NAFLD is reported to be associated with an increased risk of incident chronic kidney disease (CKD). Inflammation and oxidative stress are sugge...
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| 格式: | 文件 |
| 语言: | English |
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MDPI AG
2021-10-01
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| 丛编: | Biomedicines |
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| 在线阅读: | https://www.mdpi.com/2227-9059/9/10/1370 |
| _version_ | 1827680039034945536 |
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| author | Ilaria Umbro Francesco Baratta Francesco Angelico Maria Del Ben |
| author_facet | Ilaria Umbro Francesco Baratta Francesco Angelico Maria Del Ben |
| author_sort | Ilaria Umbro |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is associated with several extrahepatic manifestations such as cardiovascular disease and sleep apnea. Furthermore, NAFLD is reported to be associated with an increased risk of incident chronic kidney disease (CKD). Inflammation and oxidative stress are suggested to be the key factors involved in the inflammatory mechanisms and pathways linking NAFLD to CKD and are responsible for both the pathogenesis and the progression of CKD in NAFLD patients. This review aims to provide a more comprehensive overview of the association between CKD and NAFLD, also considering the effect of increasing severity of NAFLD. A PubMed search was conducted using the terms “non-alcoholic fatty liver disease AND kidney”. In total, 537 articles were retrieved in the last five years and 12 articles were included in the qualitative analysis. Our results showed that CKD developed more frequently in NAFLD patients compared to those without NAFLD. This association persisted after adjustment for traditional risk factors and according to the severity of NAFLD. Therefore, patients with NAFLD should be considered at high risk of CKD. Intensive multidisciplinary surveillance over time is needed, where hepatologists and nephrologists must act together for better and earlier treatment of NAFLD patients. |
| first_indexed | 2024-03-10T06:42:26Z |
| format | Article |
| id | doaj.art-69c81efb292c49b4b56eb58f9324df97 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T06:42:26Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-69c81efb292c49b4b56eb58f9324df972023-11-22T17:30:49ZengMDPI AGBiomedicines2227-90592021-10-01910137010.3390/biomedicines9101370Nonalcoholic Fatty Liver Disease and the Kidney: A ReviewIlaria Umbro0Francesco Baratta1Francesco Angelico2Maria Del Ben3Geramed Dialysis Center, Fiano Romano, 00065 Rome, ItalyDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyNonalcoholic fatty liver disease (NAFLD) is associated with several extrahepatic manifestations such as cardiovascular disease and sleep apnea. Furthermore, NAFLD is reported to be associated with an increased risk of incident chronic kidney disease (CKD). Inflammation and oxidative stress are suggested to be the key factors involved in the inflammatory mechanisms and pathways linking NAFLD to CKD and are responsible for both the pathogenesis and the progression of CKD in NAFLD patients. This review aims to provide a more comprehensive overview of the association between CKD and NAFLD, also considering the effect of increasing severity of NAFLD. A PubMed search was conducted using the terms “non-alcoholic fatty liver disease AND kidney”. In total, 537 articles were retrieved in the last five years and 12 articles were included in the qualitative analysis. Our results showed that CKD developed more frequently in NAFLD patients compared to those without NAFLD. This association persisted after adjustment for traditional risk factors and according to the severity of NAFLD. Therefore, patients with NAFLD should be considered at high risk of CKD. Intensive multidisciplinary surveillance over time is needed, where hepatologists and nephrologists must act together for better and earlier treatment of NAFLD patients.https://www.mdpi.com/2227-9059/9/10/1370nonalcoholic fatty liver diseaseliver fibrosischronic kidney diseaserenal functionkidney |
| spellingShingle | Ilaria Umbro Francesco Baratta Francesco Angelico Maria Del Ben Nonalcoholic Fatty Liver Disease and the Kidney: A Review Biomedicines nonalcoholic fatty liver disease liver fibrosis chronic kidney disease renal function kidney |
| title | Nonalcoholic Fatty Liver Disease and the Kidney: A Review |
| title_full | Nonalcoholic Fatty Liver Disease and the Kidney: A Review |
| title_fullStr | Nonalcoholic Fatty Liver Disease and the Kidney: A Review |
| title_full_unstemmed | Nonalcoholic Fatty Liver Disease and the Kidney: A Review |
| title_short | Nonalcoholic Fatty Liver Disease and the Kidney: A Review |
| title_sort | nonalcoholic fatty liver disease and the kidney a review |
| topic | nonalcoholic fatty liver disease liver fibrosis chronic kidney disease renal function kidney |
| url | https://www.mdpi.com/2227-9059/9/10/1370 |
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