Intake of palmitic acid and its association with metabolic flexibility in middle-aged individuals: a preliminary study
Objective: This study aimed to assess the relationship between dietary palmitic acid (PA) intake and its association with body fat deposition and metabolic flexibility (MF) in middle-aged healthy individuals. Methods: Fifteen healthy participants (n = 15; 6 males, 9 females) with a mean age of 54...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2024-02-01
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| Series: | Redox Experimental Medicine |
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| Online Access: | https://rem.bioscientifica.com/view/journals/rem/2023/1/REM-23-0022.xml |
| _version_ | 1827355102259707904 |
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| author | Elisabetta Murru Gianfranca Carta Claudia Manca Alessia Leone Chiara Murru Michele Ruggiu Roberto Solinas Roberta Montisci Filippo Tocco Sebastiano Banni |
| author_facet | Elisabetta Murru Gianfranca Carta Claudia Manca Alessia Leone Chiara Murru Michele Ruggiu Roberto Solinas Roberta Montisci Filippo Tocco Sebastiano Banni |
| author_sort | Elisabetta Murru |
| collection | DOAJ |
| description | Objective: This study aimed to assess the relationship between dietary palmitic acid (PA) intake and its association with body fat deposition and metabolic flexibility (MF) in middle-aged healthy individuals.
Methods: Fifteen healthy participants (n = 15; 6 males, 9 females) with a mean age of 54 were enlisted. They were subjected to graded exercise tests using a cycle ergometer coupled with a calorimeter. Respiratory gas exchange was evaluated to determine two MF parameters. First, the MF index was derived by multiplying peak fatty acid oxidation (PFO) per kg of fat-free mass (FFM) with the percentage of VO2max at PFO. The second parameter, peak energy substrates’ oxidation (aka PESO), was computed by aggregating the kilocalories from PFO and peak carbohydrate oxidation, normalized per kg FFM. Dietary intake was gauged using a 7-day dietary record. Spearman’s regression was employed to analyze the association between dietary intake of specific fat classes, PA, MF parameters, and body fat percentage.
Results: Preliminary results demonstrate that dietary saturated fatty acids (SFA) within physiological limits correlate with enhanced substrate oxidation capacity. This suggests augmented MF in middle-aged subjects. Among dietary SFA, PA was identified as the primary factor in this favorable correlation.
Conclusions: Our initial observations, even though preliminary, strongly suggest a beneficial association between PA intake, MF, and body fat percentage. This underscores the potential nutritional importance of PA in promoting MF.
Significance Statement
Disparities in data regarding the health effects of dietary fats may arise from the distinct roles various dietary fatty acids play in MF. |
| first_indexed | 2024-03-08T04:04:38Z |
| format | Article |
| id | doaj.art-69c897f5ecd741388c17b743176c256a |
| institution | Directory Open Access Journal |
| issn | 2755-158X |
| language | English |
| last_indexed | 2024-03-08T04:04:38Z |
| publishDate | 2024-02-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Redox Experimental Medicine |
| spelling | doaj.art-69c897f5ecd741388c17b743176c256a2024-02-09T06:48:06ZengBioscientificaRedox Experimental Medicine2755-158X2024-02-012023116https://doi.org/10.1530/REM-23-0022Intake of palmitic acid and its association with metabolic flexibility in middle-aged individuals: a preliminary studyElisabetta Murru0Gianfranca Carta1Claudia Manca2Alessia Leone3Chiara Murru4Michele Ruggiu5Roberto Solinas6Roberta Montisci7Filippo Tocco8Sebastiano Banni9Department of Biomedical Sciences, University of Cagliari, Monserrato, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, ItalyDepartment of Medical Science and Public Health, University of Cagliari, Clinical Cardiology and Sport Medicine, Monserrato, ItalyDepartment of Medical Science and Public Health, University of Cagliari, Clinical Cardiology and Sport Medicine, Monserrato, ItalyDepartment of Medical Science and Public Health, University of Cagliari, Clinical Cardiology and Sport Medicine, Monserrato, ItalyDepartment of Medical Science and Public Health, University of Cagliari, Clinical Cardiology and Sport Medicine, Monserrato, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, ItalyObjective: This study aimed to assess the relationship between dietary palmitic acid (PA) intake and its association with body fat deposition and metabolic flexibility (MF) in middle-aged healthy individuals. Methods: Fifteen healthy participants (n = 15; 6 males, 9 females) with a mean age of 54 were enlisted. They were subjected to graded exercise tests using a cycle ergometer coupled with a calorimeter. Respiratory gas exchange was evaluated to determine two MF parameters. First, the MF index was derived by multiplying peak fatty acid oxidation (PFO) per kg of fat-free mass (FFM) with the percentage of VO2max at PFO. The second parameter, peak energy substrates’ oxidation (aka PESO), was computed by aggregating the kilocalories from PFO and peak carbohydrate oxidation, normalized per kg FFM. Dietary intake was gauged using a 7-day dietary record. Spearman’s regression was employed to analyze the association between dietary intake of specific fat classes, PA, MF parameters, and body fat percentage. Results: Preliminary results demonstrate that dietary saturated fatty acids (SFA) within physiological limits correlate with enhanced substrate oxidation capacity. This suggests augmented MF in middle-aged subjects. Among dietary SFA, PA was identified as the primary factor in this favorable correlation. Conclusions: Our initial observations, even though preliminary, strongly suggest a beneficial association between PA intake, MF, and body fat percentage. This underscores the potential nutritional importance of PA in promoting MF. Significance Statement Disparities in data regarding the health effects of dietary fats may arise from the distinct roles various dietary fatty acids play in MF.https://rem.bioscientifica.com/view/journals/rem/2023/1/REM-23-0022.xmlpalmitic acidmetabolic flexibility |
| spellingShingle | Elisabetta Murru Gianfranca Carta Claudia Manca Alessia Leone Chiara Murru Michele Ruggiu Roberto Solinas Roberta Montisci Filippo Tocco Sebastiano Banni Intake of palmitic acid and its association with metabolic flexibility in middle-aged individuals: a preliminary study Redox Experimental Medicine palmitic acid metabolic flexibility |
| title | Intake of palmitic acid and its association with metabolic flexibility in middle-aged individuals: a preliminary study |
| title_full | Intake of palmitic acid and its association with metabolic flexibility in middle-aged individuals: a preliminary study |
| title_fullStr | Intake of palmitic acid and its association with metabolic flexibility in middle-aged individuals: a preliminary study |
| title_full_unstemmed | Intake of palmitic acid and its association with metabolic flexibility in middle-aged individuals: a preliminary study |
| title_short | Intake of palmitic acid and its association with metabolic flexibility in middle-aged individuals: a preliminary study |
| title_sort | intake of palmitic acid and its association with metabolic flexibility in middle aged individuals a preliminary study |
| topic | palmitic acid metabolic flexibility |
| url | https://rem.bioscientifica.com/view/journals/rem/2023/1/REM-23-0022.xml |
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