Graph theoretical analysis and application of fMRI⁃based brain network in Alzheimer's disease
Alzheimer's disease (AD), a progressive neurodegenerative disease, is clinically characterized by impaired memory and many other cognitive functions. However, the pathophysiological mechanisms underlying the disease are not thoroughly understood. In recent years, using functional magnetic reson...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2012-08-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/563 |
| _version_ | 1811308451118186496 |
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| author | Xue⁃na LIU Xin⁃qing ZHANG |
| author_facet | Xue⁃na LIU Xin⁃qing ZHANG |
| author_sort | Xue⁃na LIU |
| collection | DOAJ |
| description | Alzheimer's disease (AD), a progressive neurodegenerative disease, is clinically characterized by impaired memory and many other cognitive functions. However, the pathophysiological mechanisms underlying the disease are not thoroughly understood. In recent years, using functional magnetic resonance imaging (fMRI) as well as advanced graph theory based network analysis approach, several studies of patients with AD suggested abnormal topological organization in both global and regional properties of functional brain networks, specifically, as demonstrated by a loss of small ⁃ world network characteristics. These studies provide novel insights into the pathophysiological mechanisms of AD and could be helpful in developing imaging biomarkers for disease diagnosis. In this paper we introduce the essential concepts of complex brain networks theory, and review recent advances of the study on human functional brain networks in AD, especially focusing on the graph theoretical analysis of small ⁃ world network based on fMRI. We also propound the existent problems and research orientation.
DOI：10.3969/j.issn.1672⁃6731.2012.04.023 |
| first_indexed | 2024-04-13T09:23:22Z |
| format | Article |
| id | doaj.art-69cb2a502da843aa8a73de44c0829e0a |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-04-13T09:23:22Z |
| publishDate | 2012-08-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-69cb2a502da843aa8a73de44c0829e0a2022-12-22T02:52:31ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312012-08-01124483487562Graph theoretical analysis and application of fMRI⁃based brain network in Alzheimer's diseaseXue⁃na LIUXin⁃qing ZHANGAlzheimer's disease (AD), a progressive neurodegenerative disease, is clinically characterized by impaired memory and many other cognitive functions. However, the pathophysiological mechanisms underlying the disease are not thoroughly understood. In recent years, using functional magnetic resonance imaging (fMRI) as well as advanced graph theory based network analysis approach, several studies of patients with AD suggested abnormal topological organization in both global and regional properties of functional brain networks, specifically, as demonstrated by a loss of small ⁃ world network characteristics. These studies provide novel insights into the pathophysiological mechanisms of AD and could be helpful in developing imaging biomarkers for disease diagnosis. In this paper we introduce the essential concepts of complex brain networks theory, and review recent advances of the study on human functional brain networks in AD, especially focusing on the graph theoretical analysis of small ⁃ world network based on fMRI. We also propound the existent problems and research orientation. DOI：10.3969/j.issn.1672⁃6731.2012.04.023http://www.cjcnn.org/index.php/cjcnn/article/view/563Alzheimer diseaseMagnetic resonance imagingSmall ⁃ work network (not in MeSH)Review |
| spellingShingle | Xue⁃na LIU Xin⁃qing ZHANG Graph theoretical analysis and application of fMRI⁃based brain network in Alzheimer's disease Chinese Journal of Contemporary Neurology and Neurosurgery Alzheimer disease Magnetic resonance imaging Small ⁃ work network (not in MeSH) Review |
| title | Graph theoretical analysis and application of fMRI⁃based brain network in Alzheimer's disease |
| title_full | Graph theoretical analysis and application of fMRI⁃based brain network in Alzheimer's disease |
| title_fullStr | Graph theoretical analysis and application of fMRI⁃based brain network in Alzheimer's disease |
| title_full_unstemmed | Graph theoretical analysis and application of fMRI⁃based brain network in Alzheimer's disease |
| title_short | Graph theoretical analysis and application of fMRI⁃based brain network in Alzheimer's disease |
| title_sort | graph theoretical analysis and application of fmri⁃based brain network in alzheimer s disease |
| topic | Alzheimer disease Magnetic resonance imaging Small ⁃ work network (not in MeSH) Review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/563 |
| work_keys_str_mv | AT xuenaliu graphtheoreticalanalysisandapplicationoffmribasedbrainnetworkinalzheimersdisease AT xinqingzhang graphtheoreticalanalysisandapplicationoffmribasedbrainnetworkinalzheimersdisease |