Pillararenes as Promising Carriers for Drug Delivery
Since their discovery in 2008 by N. Ogoshi and co-authors, pillararenes (PAs) have become popular hosts for molecular recognition and supramolecular chemistry, as well as other practical applications. The most useful property of these fascinating macrocycles is their ability to accommodate reversibl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/6/5167 |
| _version_ | 1797611380602306560 |
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| author | Grigory V. Zyryanov Dmitry S. Kopchuk Igor S. Kovalev Sougata Santra Adinath Majee Brindaban C. Ranu |
| author_facet | Grigory V. Zyryanov Dmitry S. Kopchuk Igor S. Kovalev Sougata Santra Adinath Majee Brindaban C. Ranu |
| author_sort | Grigory V. Zyryanov |
| collection | DOAJ |
| description | Since their discovery in 2008 by N. Ogoshi and co-authors, pillararenes (PAs) have become popular hosts for molecular recognition and supramolecular chemistry, as well as other practical applications. The most useful property of these fascinating macrocycles is their ability to accommodate reversibly guest molecules of various kinds, including drugs or drug-like molecules, in their highly ordered rigid cavity. The last two features of pillararenes are widely used in various pillararene-based molecular devices and machines, stimuli-responsive supramolecular/host–guest systems, porous/nonporous materials, organic–inorganic hybrid systems, catalysis, and, finally, drug delivery systems. In this review, the most representative and important results on using pillararenes for drug delivery systems for the last decade are presented. |
| first_indexed | 2024-03-11T06:27:03Z |
| format | Article |
| id | doaj.art-69cffe770adc4ec587fb53fed7e1da7f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:27:03Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-69cffe770adc4ec587fb53fed7e1da7f2023-11-17T11:30:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246516710.3390/ijms24065167Pillararenes as Promising Carriers for Drug DeliveryGrigory V. Zyryanov0Dmitry S. Kopchuk1Igor S. Kovalev2Sougata Santra3Adinath Majee4Brindaban C. Ranu5Chemical Engineering Institute, Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, RussiaChemical Engineering Institute, Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, RussiaChemical Engineering Institute, Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, RussiaChemical Engineering Institute, Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, RussiaDepartment of Chemistry, Visva-Bharati University, Santiniketan 731235, IndiaChemical Engineering Institute, Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, RussiaSince their discovery in 2008 by N. Ogoshi and co-authors, pillararenes (PAs) have become popular hosts for molecular recognition and supramolecular chemistry, as well as other practical applications. The most useful property of these fascinating macrocycles is their ability to accommodate reversibly guest molecules of various kinds, including drugs or drug-like molecules, in their highly ordered rigid cavity. The last two features of pillararenes are widely used in various pillararene-based molecular devices and machines, stimuli-responsive supramolecular/host–guest systems, porous/nonporous materials, organic–inorganic hybrid systems, catalysis, and, finally, drug delivery systems. In this review, the most representative and important results on using pillararenes for drug delivery systems for the last decade are presented.https://www.mdpi.com/1422-0067/24/6/5167pillarareneshost–guest complexesaggregatesantibioticscytotoxic drugsinsulin |
| spellingShingle | Grigory V. Zyryanov Dmitry S. Kopchuk Igor S. Kovalev Sougata Santra Adinath Majee Brindaban C. Ranu Pillararenes as Promising Carriers for Drug Delivery International Journal of Molecular Sciences pillararenes host–guest complexes aggregates antibiotics cytotoxic drugs insulin |
| title | Pillararenes as Promising Carriers for Drug Delivery |
| title_full | Pillararenes as Promising Carriers for Drug Delivery |
| title_fullStr | Pillararenes as Promising Carriers for Drug Delivery |
| title_full_unstemmed | Pillararenes as Promising Carriers for Drug Delivery |
| title_short | Pillararenes as Promising Carriers for Drug Delivery |
| title_sort | pillararenes as promising carriers for drug delivery |
| topic | pillararenes host–guest complexes aggregates antibiotics cytotoxic drugs insulin |
| url | https://www.mdpi.com/1422-0067/24/6/5167 |
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