Clinical efficacy of oxidative stress correction by actovegin in diabetic polyneuropathy at type 2 diabetic patients with arterial hypertension
Aim. To study Actovegin efficacy in oxidative stress (OS) correction at diabetic polyneuropathy (DPN) in patients with diabetes mellitus type 2 (DM2)and arterial hypertension (AH).Materials and Methods. 51 patients (24 women and 27 men) aged 53.4?0.7 with the average duration of DM2 5.6?0.2 years,...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2010-06-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5680 |
| _version_ | 1797255280295149568 |
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| author | Ivan Petrovich Gorshkov Vladimir Ivanovich Zoloedov Anna Petrovna Volynkina |
| author_facet | Ivan Petrovich Gorshkov Vladimir Ivanovich Zoloedov Anna Petrovna Volynkina |
| author_sort | Ivan Petrovich Gorshkov |
| collection | DOAJ |
| description | Aim. To study Actovegin efficacy in oxidative stress (OS) correction at diabetic polyneuropathy (DPN) in patients with diabetes mellitus type 2 (DM2)and arterial hypertension (AH).Materials and Methods. 51 patients (24 women and 27 men) aged 53.4?0.7 with the average duration of DM2 5.6?0.2 years, DPN - 4.9?0.2years and AH - 6.0?0.2 years were examined. Daily albuminuria, glomerular filtration rate (GRF) were evaluated, standard methods for diagnosisof DPN were used. 26 patients took Actovegin therapy during 6-8 weeks, the rest 25 patients were in the control group. Parameters of the OS werestudied. Results. The increase of total oxidative capacity, the decrease of total antioxidant capacity and the rise of levels of antibodies to oxidated LDL wererevealed in patients with DM2, DPN and AH. Antioxidant and anti-hypoxic effects of 400 mg/day of Actovegin were established in this group of patients.Conclusions. Actovegin impacts oxidative stress parameters and improves the clinical manifestation of diabetic polyneuropathy. |
| first_indexed | 2024-03-08T15:22:22Z |
| format | Article |
| id | doaj.art-69d066b79e9944b6b870f0143f223c9f |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:03:20Z |
| publishDate | 2010-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-69d066b79e9944b6b870f0143f223c9f2024-03-20T11:47:55ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782010-06-01132848910.14341/2072-0351-56805638Clinical efficacy of oxidative stress correction by actovegin in diabetic polyneuropathy at type 2 diabetic patients with arterial hypertensionIvan Petrovich Gorshkov0Vladimir Ivanovich Zoloedov1Anna Petrovna Volynkina2Voronezh State Medical Academy named by N.N. Burdenko, VoronezhVoronezh State Medical Academy named by N.N. Burdenko, VoronezhVoronezh State Medical Academy named by N.N. Burdenko, VoronezhAim. To study Actovegin efficacy in oxidative stress (OS) correction at diabetic polyneuropathy (DPN) in patients with diabetes mellitus type 2 (DM2)and arterial hypertension (AH).Materials and Methods. 51 patients (24 women and 27 men) aged 53.4?0.7 with the average duration of DM2 5.6?0.2 years, DPN - 4.9?0.2years and AH - 6.0?0.2 years were examined. Daily albuminuria, glomerular filtration rate (GRF) were evaluated, standard methods for diagnosisof DPN were used. 26 patients took Actovegin therapy during 6-8 weeks, the rest 25 patients were in the control group. Parameters of the OS werestudied. Results. The increase of total oxidative capacity, the decrease of total antioxidant capacity and the rise of levels of antibodies to oxidated LDL wererevealed in patients with DM2, DPN and AH. Antioxidant and anti-hypoxic effects of 400 mg/day of Actovegin were established in this group of patients.Conclusions. Actovegin impacts oxidative stress parameters and improves the clinical manifestation of diabetic polyneuropathy.https://www.dia-endojournals.ru/jour/article/view/5680diabetic polyneuropathylipid peroxidationactoveginoxidative stressdiabetes mellitus |
| spellingShingle | Ivan Petrovich Gorshkov Vladimir Ivanovich Zoloedov Anna Petrovna Volynkina Clinical efficacy of oxidative stress correction by actovegin in diabetic polyneuropathy at type 2 diabetic patients with arterial hypertension Сахарный диабет diabetic polyneuropathy lipid peroxidation actovegin oxidative stress diabetes mellitus |
| title | Clinical efficacy of oxidative stress correction by actovegin in diabetic polyneuropathy at type 2 diabetic patients with arterial hypertension |
| title_full | Clinical efficacy of oxidative stress correction by actovegin in diabetic polyneuropathy at type 2 diabetic patients with arterial hypertension |
| title_fullStr | Clinical efficacy of oxidative stress correction by actovegin in diabetic polyneuropathy at type 2 diabetic patients with arterial hypertension |
| title_full_unstemmed | Clinical efficacy of oxidative stress correction by actovegin in diabetic polyneuropathy at type 2 diabetic patients with arterial hypertension |
| title_short | Clinical efficacy of oxidative stress correction by actovegin in diabetic polyneuropathy at type 2 diabetic patients with arterial hypertension |
| title_sort | clinical efficacy of oxidative stress correction by actovegin in diabetic polyneuropathy at type 2 diabetic patients with arterial hypertension |
| topic | diabetic polyneuropathy lipid peroxidation actovegin oxidative stress diabetes mellitus |
| url | https://www.dia-endojournals.ru/jour/article/view/5680 |
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