Increased leishmanicidal activity of alveolar macrophages from mature horses with mild equine asthma
ABSTRACT Alveolar macrophages (AMs) are an essential part of defense mechanisms within the lungs and their phagocytic activity is important for organ homeostasis. The phagocytic ability of AMs obtained from bronchoalveolar lavage from 17 mature mixed-breed pleasure horses (8 healthy and 9 diagnosed...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Minas Gerais
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| Series: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000300939&lng=en&tlng=en |
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| author | D.A.B. Lessa N.X. Alencar R.A. Torres Filho M.F.M. Costa W.R. Fernandes E.M. Saraiva |
| author_facet | D.A.B. Lessa N.X. Alencar R.A. Torres Filho M.F.M. Costa W.R. Fernandes E.M. Saraiva |
| author_sort | D.A.B. Lessa |
| collection | DOAJ |
| description | ABSTRACT Alveolar macrophages (AMs) are an essential part of defense mechanisms within the lungs and their phagocytic activity is important for organ homeostasis. The phagocytic ability of AMs obtained from bronchoalveolar lavage from 17 mature mixed-breed pleasure horses (8 healthy and 9 diagnosed with mild equine asthma) was studied through assays with Leishmania (Viannia) braziliensis promastigotes, which enabled the calculation of a phagocytic index (PI) and a survival index (SI). Results indicate that phagocytic activity of AMs in asthma affected horses is similar to healthy horses, while leishmanicidal activity is significantly increased in horses with asthma. |
| first_indexed | 2024-12-14T00:35:23Z |
| format | Article |
| id | doaj.art-69d133ac61bc4ca4954d0fee3852f93a |
| institution | Directory Open Access Journal |
| issn | 1678-4162 |
| language | English |
| last_indexed | 2024-12-14T00:35:23Z |
| publisher | Universidade Federal de Minas Gerais |
| record_format | Article |
| series | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| spelling | doaj.art-69d133ac61bc4ca4954d0fee3852f93a2022-12-21T23:24:41ZengUniversidade Federal de Minas GeraisArquivo Brasileiro de Medicina Veterinária e Zootecnia1678-416271393994310.1590/1678-4162-10708S0102-09352019000300939Increased leishmanicidal activity of alveolar macrophages from mature horses with mild equine asthmaD.A.B. LessaN.X. AlencarR.A. Torres FilhoM.F.M. CostaW.R. FernandesE.M. SaraivaABSTRACT Alveolar macrophages (AMs) are an essential part of defense mechanisms within the lungs and their phagocytic activity is important for organ homeostasis. The phagocytic ability of AMs obtained from bronchoalveolar lavage from 17 mature mixed-breed pleasure horses (8 healthy and 9 diagnosed with mild equine asthma) was studied through assays with Leishmania (Viannia) braziliensis promastigotes, which enabled the calculation of a phagocytic index (PI) and a survival index (SI). Results indicate that phagocytic activity of AMs in asthma affected horses is similar to healthy horses, while leishmanicidal activity is significantly increased in horses with asthma.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000300939&lng=en&tlng=enhorsesequine asthmaalveolar macrophagephagocytosisLeishmania (Viannia) braziliensis |
| spellingShingle | D.A.B. Lessa N.X. Alencar R.A. Torres Filho M.F.M. Costa W.R. Fernandes E.M. Saraiva Increased leishmanicidal activity of alveolar macrophages from mature horses with mild equine asthma Arquivo Brasileiro de Medicina Veterinária e Zootecnia horses equine asthma alveolar macrophage phagocytosis Leishmania (Viannia) braziliensis |
| title | Increased leishmanicidal activity of alveolar macrophages from mature horses with mild equine asthma |
| title_full | Increased leishmanicidal activity of alveolar macrophages from mature horses with mild equine asthma |
| title_fullStr | Increased leishmanicidal activity of alveolar macrophages from mature horses with mild equine asthma |
| title_full_unstemmed | Increased leishmanicidal activity of alveolar macrophages from mature horses with mild equine asthma |
| title_short | Increased leishmanicidal activity of alveolar macrophages from mature horses with mild equine asthma |
| title_sort | increased leishmanicidal activity of alveolar macrophages from mature horses with mild equine asthma |
| topic | horses equine asthma alveolar macrophage phagocytosis Leishmania (Viannia) braziliensis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000300939&lng=en&tlng=en |
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