Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography
Abstract The drivers of sexual dimorphism in heart failure phenotypes are currently poorly understood. Divergent phenotypes may result from differences in heritability and genetic versus environmental influences on the interplay of cardiac structure and function. To assess sex-specific heritability...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32577-6 |
| _version_ | 1797850100673806336 |
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| author | Honghuang Lin Alan C. Kwan Cecilia Castro-Diehl Meghan I. Short Vanessa Xanthakis Ibrahim M. Yola Gerran Salto Gary F. Mitchell Martin G. Larson Ramachandran S. Vasan Susan Cheng |
| author_facet | Honghuang Lin Alan C. Kwan Cecilia Castro-Diehl Meghan I. Short Vanessa Xanthakis Ibrahim M. Yola Gerran Salto Gary F. Mitchell Martin G. Larson Ramachandran S. Vasan Susan Cheng |
| author_sort | Honghuang Lin |
| collection | DOAJ |
| description | Abstract The drivers of sexual dimorphism in heart failure phenotypes are currently poorly understood. Divergent phenotypes may result from differences in heritability and genetic versus environmental influences on the interplay of cardiac structure and function. To assess sex-specific heritability and genetic versus environmental contributions to variation and inter-relations between echocardiography traits in a large community-based cohort. We studied Framingham Heart Study participants of Offspring Cohort examination 8 (2005–2008) and Third Generation Cohort examination 1 (2002–2005). Five cardiac traits and six functional traits were measured using standardized echocardiography. Sequential Oligogenic Linkage Analysis Routines (SOLAR) software was used to perform singular and bivariate quantitative trait linkage analysis. In our study of 5674 participants (age 49 ± 15 years; 54% women), heritability for all traits was significant for both men and women. There were no significant differences in traits between men and women. Within inter-trait correlations, there were two genetic, and four environmental trait pairs with sex-based differences. Within both significant genetic trait pairs, men had a positive relation, and women had no significant relation. We observed significant sex-based differences in inter-trait genetic and environmental correlations between cardiac structure and function. These findings highlight potential pathways of sex-based divergent heart failure phenotypes. |
| first_indexed | 2024-04-09T18:54:53Z |
| format | Article |
| id | doaj.art-69d134e7d644458c851acfb610f53b02 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T18:54:53Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-69d134e7d644458c851acfb610f53b022023-04-09T11:14:21ZengNature PortfolioScientific Reports2045-23222023-04-011311610.1038/s41598-023-32577-6Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiographyHonghuang Lin0Alan C. Kwan1Cecilia Castro-Diehl2Meghan I. Short3Vanessa Xanthakis4Ibrahim M. Yola5Gerran Salto6Gary F. Mitchell7Martin G. Larson8Ramachandran S. Vasan9Susan Cheng10Department of Medicine, University of Massachusetts Chan Medical SchoolDepartment of Cardiology, Cedars-Sinai Medical CenterSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of MedicineGlenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health San AntonioFramingham Heart StudySection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of MedicineDepartment of Cardiology, Cedars-Sinai Medical CenterCardiovascular Engineering, Inc.Framingham Heart StudyFramingham Heart StudyFramingham Heart StudyAbstract The drivers of sexual dimorphism in heart failure phenotypes are currently poorly understood. Divergent phenotypes may result from differences in heritability and genetic versus environmental influences on the interplay of cardiac structure and function. To assess sex-specific heritability and genetic versus environmental contributions to variation and inter-relations between echocardiography traits in a large community-based cohort. We studied Framingham Heart Study participants of Offspring Cohort examination 8 (2005–2008) and Third Generation Cohort examination 1 (2002–2005). Five cardiac traits and six functional traits were measured using standardized echocardiography. Sequential Oligogenic Linkage Analysis Routines (SOLAR) software was used to perform singular and bivariate quantitative trait linkage analysis. In our study of 5674 participants (age 49 ± 15 years; 54% women), heritability for all traits was significant for both men and women. There were no significant differences in traits between men and women. Within inter-trait correlations, there were two genetic, and four environmental trait pairs with sex-based differences. Within both significant genetic trait pairs, men had a positive relation, and women had no significant relation. We observed significant sex-based differences in inter-trait genetic and environmental correlations between cardiac structure and function. These findings highlight potential pathways of sex-based divergent heart failure phenotypes.https://doi.org/10.1038/s41598-023-32577-6 |
| spellingShingle | Honghuang Lin Alan C. Kwan Cecilia Castro-Diehl Meghan I. Short Vanessa Xanthakis Ibrahim M. Yola Gerran Salto Gary F. Mitchell Martin G. Larson Ramachandran S. Vasan Susan Cheng Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography Scientific Reports |
| title | Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography |
| title_full | Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography |
| title_fullStr | Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography |
| title_full_unstemmed | Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography |
| title_short | Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography |
| title_sort | sex specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography |
| url | https://doi.org/10.1038/s41598-023-32577-6 |
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