Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy
Abstract Background The optimal treatment for lacrimal gland cancer remains unclear. Eye-preserving surgery, as opposed to exenteration, followed by adjuvant radiotherapy (RT), has recently been reported to deliver satisfactory outcomes, but evidence is sparse. The aim of the present study was to ev...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-020-01601-8 |
| _version_ | 1818504138940481536 |
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| author | Yun-Hsuan Lin Shih-Ming Huang Wing-Keen Yap Ju-Wen Yang Ling Yeung Din-Li Tsan Joseph Tung-Chieh Chang Lung-Chien Chen |
| author_facet | Yun-Hsuan Lin Shih-Ming Huang Wing-Keen Yap Ju-Wen Yang Ling Yeung Din-Li Tsan Joseph Tung-Chieh Chang Lung-Chien Chen |
| author_sort | Yun-Hsuan Lin |
| collection | DOAJ |
| description | Abstract Background The optimal treatment for lacrimal gland cancer remains unclear. Eye-preserving surgery, as opposed to exenteration, followed by adjuvant radiotherapy (RT), has recently been reported to deliver satisfactory outcomes, but evidence is sparse. The aim of the present study was to evaluate outcomes in patients with lacrimal gland cancer treated at two tertiary medical centers. Methods We retrospectively examined data from patients with lacrimal gland cancer who had received eye-preserving surgical treatment followed by adjuvant RT with or without chemotherapy, or (if the tumor was inoperable) needle biopsy with definitive RT with or without chemotherapy. Baseline clinical and pathological characteristics were considered. Outcomes of interest included post-treatment complications, overall survival (OS), locoregional progression-free survival (LPFS), and distant metastasis-free survival (DMFS). Results Eighteen patients were included. Two-year OS, LPFS, and DMFS rates were 69.0, 76.7, and 71.4%, respectively. Patients with early-stage (T1–T2) lacrimal gland cancer had significantly better outcomes than those with advanced-stage disease (T3–T4). Two-year OS, LPFS, and DMFS rates were each 100% in patients with disease stages T1–T2, and 37.5, 50, and 37.5%, respectively, in those with disease stages T3–T4 (P < 0.05). Orbital complications were well tolerated. Conclusions Eye-sparing surgery with adjuvant RT can achieve satisfactory results in patients with T1–T2 lacrimal gland carcinoma. Disease stage T3 and above was associated with poor outcomes even with post-operative RT, likely due to distant metastasis. Adding neoadjuvant chemotherapy or adjuvant chemotherapy to current treatment strategies might be a suitable choice for this group of patients. |
| first_indexed | 2024-12-10T21:33:08Z |
| format | Article |
| id | doaj.art-69d2c7ea398d41bcb6b86222fdcac047 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-10T21:33:08Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-69d2c7ea398d41bcb6b86222fdcac0472022-12-22T01:32:43ZengBMCRadiation Oncology1748-717X2020-06-0115111010.1186/s13014-020-01601-8Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapyYun-Hsuan Lin0Shih-Ming Huang1Wing-Keen Yap2Ju-Wen Yang3Ling Yeung4Din-Li Tsan5Joseph Tung-Chieh Chang6Lung-Chien Chen7Department of Electro-Optical Engineering, National Taipei University of TechnologyCollege of Medicine, Chang Gung UniversityDepartment of Radiation Oncology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Radiation Oncology, Chang Gung Memorial HospitalDepartment of Radiation Oncology, Chang Gung Memorial HospitalDepartment of Electro-Optical Engineering, National Taipei University of TechnologyAbstract Background The optimal treatment for lacrimal gland cancer remains unclear. Eye-preserving surgery, as opposed to exenteration, followed by adjuvant radiotherapy (RT), has recently been reported to deliver satisfactory outcomes, but evidence is sparse. The aim of the present study was to evaluate outcomes in patients with lacrimal gland cancer treated at two tertiary medical centers. Methods We retrospectively examined data from patients with lacrimal gland cancer who had received eye-preserving surgical treatment followed by adjuvant RT with or without chemotherapy, or (if the tumor was inoperable) needle biopsy with definitive RT with or without chemotherapy. Baseline clinical and pathological characteristics were considered. Outcomes of interest included post-treatment complications, overall survival (OS), locoregional progression-free survival (LPFS), and distant metastasis-free survival (DMFS). Results Eighteen patients were included. Two-year OS, LPFS, and DMFS rates were 69.0, 76.7, and 71.4%, respectively. Patients with early-stage (T1–T2) lacrimal gland cancer had significantly better outcomes than those with advanced-stage disease (T3–T4). Two-year OS, LPFS, and DMFS rates were each 100% in patients with disease stages T1–T2, and 37.5, 50, and 37.5%, respectively, in those with disease stages T3–T4 (P < 0.05). Orbital complications were well tolerated. Conclusions Eye-sparing surgery with adjuvant RT can achieve satisfactory results in patients with T1–T2 lacrimal gland carcinoma. Disease stage T3 and above was associated with poor outcomes even with post-operative RT, likely due to distant metastasis. Adding neoadjuvant chemotherapy or adjuvant chemotherapy to current treatment strategies might be a suitable choice for this group of patients.http://link.springer.com/article/10.1186/s13014-020-01601-8Lacrimal gland carcinomaOrbital tumorsRadiotherapyOrbital exenteration |
| spellingShingle | Yun-Hsuan Lin Shih-Ming Huang Wing-Keen Yap Ju-Wen Yang Ling Yeung Din-Li Tsan Joseph Tung-Chieh Chang Lung-Chien Chen Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy Radiation Oncology Lacrimal gland carcinoma Orbital tumors Radiotherapy Orbital exenteration |
| title | Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy |
| title_full | Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy |
| title_fullStr | Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy |
| title_full_unstemmed | Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy |
| title_short | Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy |
| title_sort | outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye sparing surgery followed by adjuvant radiotherapy |
| topic | Lacrimal gland carcinoma Orbital tumors Radiotherapy Orbital exenteration |
| url | http://link.springer.com/article/10.1186/s13014-020-01601-8 |
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