Metabolic and nutritional approach to older frail people
Frailty is a common clinical syndrome in older adults that carries an increased risk for poor health outcomes including falls, incident disability, hospitalization, and mortality. It is characterized by multisystem dysregulations, leading to a loss of dynamic homeostasis, decreased physiologic reser...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2017-09-01
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| Series: | Geriatric Care |
| Subjects: | |
| Online Access: | http://www.pagepressjournals.org/index.php/gc/article/view/7056 |
| _version_ | 1828398751194021888 |
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| author | Stefano Volpato Giovanni Zuliani |
| author_facet | Stefano Volpato Giovanni Zuliani |
| author_sort | Stefano Volpato |
| collection | DOAJ |
| description | Frailty is a common clinical syndrome in older adults that carries an increased risk for poor health outcomes including falls, incident disability, hospitalization, and mortality. It is characterized by multisystem dysregulations, leading to a loss of dynamic homeostasis, decreased physiologic reserve, and increased vulnerability to stressors. A large body of literature suggests several important multisystem pathophysiologic processes in the pathogenesis of the frailty syndrome, including chronic inflammation and immune activation, insulin resistance and those in musculoskeletal and endocrine systems. Currently, no effective pharmaceutical interventions have been developed for the prevention and treatment of the frailty syndrome. Conversely, epidemiological and intervention studies suggest that adequate nutrition and physical exercise might prevent or postpone the onset of frailty and related clinical manifestations. |
| first_indexed | 2024-12-10T09:06:18Z |
| format | Article |
| id | doaj.art-69d513b109ba442babe2623bf7210d2a |
| institution | Directory Open Access Journal |
| issn | 2465-1109 2465-1397 |
| language | English |
| last_indexed | 2024-12-10T09:06:18Z |
| publishDate | 2017-09-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Geriatric Care |
| spelling | doaj.art-69d513b109ba442babe2623bf7210d2a2022-12-22T01:55:08ZengPAGEPress PublicationsGeriatric Care2465-11092465-13972017-09-013310.4081/gc.2017.70565395Metabolic and nutritional approach to older frail peopleStefano Volpato0Giovanni Zuliani1Department of Medical Science, University of FerraraDepartment of Medical Science, University of FerraraFrailty is a common clinical syndrome in older adults that carries an increased risk for poor health outcomes including falls, incident disability, hospitalization, and mortality. It is characterized by multisystem dysregulations, leading to a loss of dynamic homeostasis, decreased physiologic reserve, and increased vulnerability to stressors. A large body of literature suggests several important multisystem pathophysiologic processes in the pathogenesis of the frailty syndrome, including chronic inflammation and immune activation, insulin resistance and those in musculoskeletal and endocrine systems. Currently, no effective pharmaceutical interventions have been developed for the prevention and treatment of the frailty syndrome. Conversely, epidemiological and intervention studies suggest that adequate nutrition and physical exercise might prevent or postpone the onset of frailty and related clinical manifestations.http://www.pagepressjournals.org/index.php/gc/article/view/7056Frailtynutritionpreventionepidemiology. |
| spellingShingle | Stefano Volpato Giovanni Zuliani Metabolic and nutritional approach to older frail people Geriatric Care Frailty nutrition prevention epidemiology. |
| title | Metabolic and nutritional approach to older frail people |
| title_full | Metabolic and nutritional approach to older frail people |
| title_fullStr | Metabolic and nutritional approach to older frail people |
| title_full_unstemmed | Metabolic and nutritional approach to older frail people |
| title_short | Metabolic and nutritional approach to older frail people |
| title_sort | metabolic and nutritional approach to older frail people |
| topic | Frailty nutrition prevention epidemiology. |
| url | http://www.pagepressjournals.org/index.php/gc/article/view/7056 |
| work_keys_str_mv | AT stefanovolpato metabolicandnutritionalapproachtoolderfrailpeople AT giovannizuliani metabolicandnutritionalapproachtoolderfrailpeople |