Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects.
Associations between dietary patterns, metabolic and inflammatory markers and gut microbiota are yet to be elucidated.We aimed to characterize dietary patterns in overweight and obese subjects and evaluate the different dietary patterns in relation to metabolic and inflammatory variables as well as...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4203727?pdf=render |
| _version_ | 1811278791801044992 |
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| author | Ling Chun Kong Bridget A Holmes Aurelie Cotillard Fatiha Habi-Rachedi Rémi Brazeilles Sophie Gougis Nicolas Gausserès Patrice D Cani Soraya Fellahi Jean-Philippe Bastard Sean P Kennedy Joel Doré Stanislav Dusko Ehrlich Jean-Daniel Zucker Salwa W Rizkalla Karine Clément |
| author_facet | Ling Chun Kong Bridget A Holmes Aurelie Cotillard Fatiha Habi-Rachedi Rémi Brazeilles Sophie Gougis Nicolas Gausserès Patrice D Cani Soraya Fellahi Jean-Philippe Bastard Sean P Kennedy Joel Doré Stanislav Dusko Ehrlich Jean-Daniel Zucker Salwa W Rizkalla Karine Clément |
| author_sort | Ling Chun Kong |
| collection | DOAJ |
| description | Associations between dietary patterns, metabolic and inflammatory markers and gut microbiota are yet to be elucidated.We aimed to characterize dietary patterns in overweight and obese subjects and evaluate the different dietary patterns in relation to metabolic and inflammatory variables as well as gut microbiota.Dietary patterns, plasma and adipose tissue markers, and gut microbiota were evaluated in a group of 45 overweight and obese subjects (6 men and 39 women). A group of 14 lean subjects were also evaluated as a reference group.Three clusters of dietary patterns were identified in overweight/obese subjects. Cluster 1 had the least healthy eating behavior (highest consumption of potatoes, confectionary and sugary drinks, and the lowest consumption of fruits that was associated also with low consumption of yogurt, and water). This dietary pattern was associated with the highest LDL cholesterol, plasma soluble CD14 (p = 0.01) a marker of systemic inflammation but the lowest accumulation of CD163+ macrophages with anti-inflammatory profile in adipose tissue (p = 0.05). Cluster 3 had the healthiest eating behavior (lower consumption of confectionary and sugary drinks, and highest consumption of fruits but also yogurts and soups). Subjects in this Cluster had the lowest inflammatory markers (sCD14) and the highest anti-inflammatory adipose tissue CD163+ macrophages. Dietary intakes, insulin sensitivity and some inflammatory markers (plasma IL6) in Cluster 3 were close to those of lean subjects. Cluster 2 was in-between clusters 1 and 3 in terms of healthfulness. The 7 gut microbiota groups measured by qPCR were similar across the clusters. However, the healthiest dietary cluster had the highest microbial gene richness, as evaluated by quantitative metagenomics.A healthier dietary pattern was associated with lower inflammatory markers as well as greater gut microbiota richness in overweight and obese subjects.ClinicalTrials.gov NCT01314690. |
| first_indexed | 2024-04-13T00:42:04Z |
| format | Article |
| id | doaj.art-69d53df8e4604109965ecd34cadff970 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T00:42:04Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-69d53df8e4604109965ecd34cadff9702022-12-22T03:10:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e10943410.1371/journal.pone.0109434Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects.Ling Chun KongBridget A HolmesAurelie CotillardFatiha Habi-RachediRémi BrazeillesSophie GougisNicolas GausserèsPatrice D CaniSoraya FellahiJean-Philippe BastardSean P KennedyJoel DoréStanislav Dusko EhrlichJean-Daniel ZuckerSalwa W RizkallaKarine ClémentAssociations between dietary patterns, metabolic and inflammatory markers and gut microbiota are yet to be elucidated.We aimed to characterize dietary patterns in overweight and obese subjects and evaluate the different dietary patterns in relation to metabolic and inflammatory variables as well as gut microbiota.Dietary patterns, plasma and adipose tissue markers, and gut microbiota were evaluated in a group of 45 overweight and obese subjects (6 men and 39 women). A group of 14 lean subjects were also evaluated as a reference group.Three clusters of dietary patterns were identified in overweight/obese subjects. Cluster 1 had the least healthy eating behavior (highest consumption of potatoes, confectionary and sugary drinks, and the lowest consumption of fruits that was associated also with low consumption of yogurt, and water). This dietary pattern was associated with the highest LDL cholesterol, plasma soluble CD14 (p = 0.01) a marker of systemic inflammation but the lowest accumulation of CD163+ macrophages with anti-inflammatory profile in adipose tissue (p = 0.05). Cluster 3 had the healthiest eating behavior (lower consumption of confectionary and sugary drinks, and highest consumption of fruits but also yogurts and soups). Subjects in this Cluster had the lowest inflammatory markers (sCD14) and the highest anti-inflammatory adipose tissue CD163+ macrophages. Dietary intakes, insulin sensitivity and some inflammatory markers (plasma IL6) in Cluster 3 were close to those of lean subjects. Cluster 2 was in-between clusters 1 and 3 in terms of healthfulness. The 7 gut microbiota groups measured by qPCR were similar across the clusters. However, the healthiest dietary cluster had the highest microbial gene richness, as evaluated by quantitative metagenomics.A healthier dietary pattern was associated with lower inflammatory markers as well as greater gut microbiota richness in overweight and obese subjects.ClinicalTrials.gov NCT01314690.http://europepmc.org/articles/PMC4203727?pdf=render |
| spellingShingle | Ling Chun Kong Bridget A Holmes Aurelie Cotillard Fatiha Habi-Rachedi Rémi Brazeilles Sophie Gougis Nicolas Gausserès Patrice D Cani Soraya Fellahi Jean-Philippe Bastard Sean P Kennedy Joel Doré Stanislav Dusko Ehrlich Jean-Daniel Zucker Salwa W Rizkalla Karine Clément Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects. PLoS ONE |
| title | Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects. |
| title_full | Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects. |
| title_fullStr | Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects. |
| title_full_unstemmed | Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects. |
| title_short | Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects. |
| title_sort | dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects |
| url | http://europepmc.org/articles/PMC4203727?pdf=render |
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