The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms
Myeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the role of FasR/FasL in the pathogenesis of MPNs...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2010-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641002223S.pdf |
| _version_ | 1811263762734252032 |
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| author | Spasovski Vesna Tosić Natasa Kostić Tatjana Zukić Branka Stojiljković Maja Čolović Milica Pavlović Sonja |
| author_facet | Spasovski Vesna Tosić Natasa Kostić Tatjana Zukić Branka Stojiljković Maja Čolović Milica Pavlović Sonja |
| author_sort | Spasovski Vesna |
| collection | DOAJ |
| description | Myeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the role of FasR/FasL in the pathogenesis of MPNs. We compared FasR/FasL expression between MPN patients (24) and healthy individuals using the real-time PCR assay. We found an increase of FasR expression in MPN patients. No difference was detected in FasL expression. Mutation V617F in the JAK2 gene, a hallmark of MPN, was detected in 13/24 patients. We found that neither FasR nor FasL expression were related to the presence of JAK2 V617F mutation. |
| first_indexed | 2024-04-12T19:51:04Z |
| format | Article |
| id | doaj.art-69d5626d6ea44068ba6e07345d96fcbe |
| institution | Directory Open Access Journal |
| issn | 0354-4664 |
| language | English |
| last_indexed | 2024-04-12T19:51:04Z |
| publishDate | 2010-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-69d5626d6ea44068ba6e07345d96fcbe2022-12-22T03:18:49ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642010-01-0162222323010.2298/ABS1002223SThe role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasmsSpasovski VesnaTosić NatasaKostić TatjanaZukić BrankaStojiljković MajaČolović MilicaPavlović SonjaMyeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the role of FasR/FasL in the pathogenesis of MPNs. We compared FasR/FasL expression between MPN patients (24) and healthy individuals using the real-time PCR assay. We found an increase of FasR expression in MPN patients. No difference was detected in FasL expression. Mutation V617F in the JAK2 gene, a hallmark of MPN, was detected in 13/24 patients. We found that neither FasR nor FasL expression were related to the presence of JAK2 V617F mutation.http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641002223S.pdfMyeloproliferative neoplasmsFasR/FasLJAK2 V617F mutation |
| spellingShingle | Spasovski Vesna Tosić Natasa Kostić Tatjana Zukić Branka Stojiljković Maja Čolović Milica Pavlović Sonja The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms Archives of Biological Sciences Myeloproliferative neoplasms FasR/FasL JAK2 V617F mutation |
| title | The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms |
| title_full | The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms |
| title_fullStr | The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms |
| title_full_unstemmed | The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms |
| title_short | The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms |
| title_sort | role of fasr fasl system in pathogenesis of myeloprolyferative neoplasms |
| topic | Myeloproliferative neoplasms FasR/FasL JAK2 V617F mutation |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641002223S.pdf |
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