GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells
Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy. The occurrence of various side effect of Sal greatly limits its application. The epidermal growth factor receptor (EGFR) family is a family of receptors highly expressed in most breast cancer ce...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-05-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338211004954 |
| _version_ | 1811238632102559744 |
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| author | Kaichun Li MD Liying Pang MS Xiaorong Pan MS Shaonan Fan MS Xinxin Wang MS Qiaoyun Wang MS Ping Dai MS Wei Gao MD Jie Gao PhD |
| author_facet | Kaichun Li MD Liying Pang MS Xiaorong Pan MS Shaonan Fan MS Xinxin Wang MS Qiaoyun Wang MS Ping Dai MS Wei Gao MD Jie Gao PhD |
| author_sort | Kaichun Li MD |
| collection | DOAJ |
| description | Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy. The occurrence of various side effect of Sal greatly limits its application. The epidermal growth factor receptor (EGFR) family is a family of receptors highly expressed in most breast cancer cells. GE11 is a dodecapeptide which shows excellent EGFR affinity. A series of nanoparticles derivatives with GE11 peptide conjugated PLGA/TPGS were synthesized. Nanoprecipitation method was used to prepare the Sal loaded nanoparticles at the optimized concentration. The characterization, targeting efficacy, and antitumor activity were detected both in vitro and in vivo . Encapsulation of Sal in GE11 modified PLGA/TPGS nanoparticles shows an improved therapy efficacy and lower systemic side effect. This represents the delivery system a promising strategy to enhance the therapeutic effect against EGFR highly expressed breast cancer. |
| first_indexed | 2024-04-12T12:45:05Z |
| format | Article |
| id | doaj.art-69d5b8c691f946398c1c5ea6f93cff8e |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-12T12:45:05Z |
| publishDate | 2021-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-69d5b8c691f946398c1c5ea6f93cff8e2022-12-22T03:32:38ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382021-05-012010.1177/15330338211004954GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer CellsKaichun Li MD0Liying Pang MS1Xiaorong Pan MS2Shaonan Fan MS3Xinxin Wang MS4Qiaoyun Wang MS5Ping Dai MS6Wei Gao MD7Jie Gao PhD8 Department of Oncology, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, China Institute of Translational Medicine, Shanghai University, Shanghai, China Department of Oncology, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, China Department of Radiation Oncology, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, China Department of Oncology, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, China Department of Oncology, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, China Department of Oncology, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, China Department of Radiation Oncology, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, China Institute of Translational Medicine, Shanghai University, Shanghai, ChinaSalinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy. The occurrence of various side effect of Sal greatly limits its application. The epidermal growth factor receptor (EGFR) family is a family of receptors highly expressed in most breast cancer cells. GE11 is a dodecapeptide which shows excellent EGFR affinity. A series of nanoparticles derivatives with GE11 peptide conjugated PLGA/TPGS were synthesized. Nanoprecipitation method was used to prepare the Sal loaded nanoparticles at the optimized concentration. The characterization, targeting efficacy, and antitumor activity were detected both in vitro and in vivo . Encapsulation of Sal in GE11 modified PLGA/TPGS nanoparticles shows an improved therapy efficacy and lower systemic side effect. This represents the delivery system a promising strategy to enhance the therapeutic effect against EGFR highly expressed breast cancer.https://doi.org/10.1177/15330338211004954 |
| spellingShingle | Kaichun Li MD Liying Pang MS Xiaorong Pan MS Shaonan Fan MS Xinxin Wang MS Qiaoyun Wang MS Ping Dai MS Wei Gao MD Jie Gao PhD GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells Technology in Cancer Research & Treatment |
| title | GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells |
| title_full | GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells |
| title_fullStr | GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells |
| title_full_unstemmed | GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells |
| title_short | GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells |
| title_sort | ge11 modified plga tpgs nanoparticles targeting delivery of salinomycin to breast cancer cells |
| url | https://doi.org/10.1177/15330338211004954 |
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