Modeling the Interactions Between Sodium Channels Provides Insight Into the Negative Dominance of Certain Channel Mutations

Modeling the Interactions Between Sodium Channels Provides Insight Into the Negative Dominance of Certain Channel Mutations

BackgroundNav1.5 cardiac Na+ channel mutations can cause arrhythmogenic syndromes. Some of these mutations exert a dominant negative effect on wild-type channels. Recent studies showed that Na+ channels can dimerize, allowing coupled gating. This leads to the hypothesis that allosteric interactions...

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Bibliographic Details
Main Authors: Echrak Hichri, Zoja Selimi, Jan P. Kucera
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
cardiac electrophysiology
sodium channels
sodium current
allosteric interactions
computer modeling
Markov models
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.589386/full

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