Efficacy of Celecoxib and Diclofenac Sodium in the Management of Postoperative Pain, Swelling and Mouth Opening after Surgical Removal of Impacted Third Molars: A Split-mouth Randomised Clinical Study
Introduction: The surgical removal of mandibular third molars is generally followed by complaints of pain, trismus, and swelling. The duration of surgery and the reflection of a mucoperiosteal flap have been shown to affect the intensity and frequency of postoperative complaints. Pain from t...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/18307/63808_CE[Ra1]_F(IS)_PF1(HB_KM_OM)_QC(SHK_SS)_PFA_NC(KM)_PN(KM).pdf |
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| author | Gaurav Kumar Jha Rajesh Ashok Kshirsagar Vikram Singh Sudhir Ramlal Pawar Vivek Nair Daksh Manish Kedia Ojas Desai Saurabh Jain |
| author_facet | Gaurav Kumar Jha Rajesh Ashok Kshirsagar Vikram Singh Sudhir Ramlal Pawar Vivek Nair Daksh Manish Kedia Ojas Desai Saurabh Jain |
| author_sort | Gaurav Kumar Jha |
| collection | DOAJ |
| description | Introduction: The surgical removal of mandibular third molars is
generally followed by complaints of pain, trismus, and swelling.
The duration of surgery and the reflection of a mucoperiosteal
flap have been shown to affect the intensity and frequency of
postoperative complaints. Pain from third molar surgery typically
begins within one to three hours after surgery and ranges in
intensity from moderate to severe. Numerous analgesics have
been used to minimise pain and discomfort following the
surgical removal of impacted third molars. Commonly used
agents include ibuprofen, diclofenac sodium, paracetamol,
or their combinations. Newer drugs, such as selective COX
inhibitors, have not been extensively used for minor oral surgical
procedures.
Aim: To compare the clinical efficacy of celecoxib and diclofenac
sodium on pain, swelling, and mouth opening after the surgical
removal of impacted mandibular third molars.
Materials and Methods: A split-mouth randomised controlled
clinical trial was conducted in the Department of Oral and
Maxillofacial Surgery at BharatiVidyapeeth DU Dental College and
Hospital, Pune, Maharashtra, India. The study duration was six
months, from August 2022 to January 2023. A total of 21 subjects
(11 males and 10 females) who required surgical extraction of an
impacted mandibular third molar were selected. All subjects were
randomly allocated to receive one of the following treatments
twice a day for five days after surgery: celecoxib 200 mg (n=11)
or diclofenac sodium 75 mg (n=10). Pain scores were evaluated
using the Visual Analogue Scale (VAS) on postoperative day one,
two, and three. Swelling and mouth opening were evaluated on
Postoperative Day (POD) two and seven. Intergroup comparison
was done using Student’s t-test.
Results: The mean age of the study participants was 28±1.5
years, and the mean VAS score for pain evaluation with celecoxib
was 6.61, 5.38, and 5.00 on day 1 (p=0.027), 2 (p=0.972), and 3
(p=0.809), respectively. The difference in swelling values for the
celecoxib group was significant, while there were no significant
differences in the values of mouth opening.
Conclusion: It was concluded that celecoxib 200 mg is a better
analgesic and anti-inflammatory compared to diclofenac sodium
75 mg. Celecoxib was easily tolerable and comfortable for the
patients. There was no significant difference in the values of
mouth opening.
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| first_indexed | 2024-03-12T01:19:32Z |
| format | Article |
| id | doaj.art-69d6fc0bae9c44e886de52e8fe4e2dc2 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-12T01:19:32Z |
| publishDate | 2023-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-69d6fc0bae9c44e886de52e8fe4e2dc22023-09-13T07:48:17ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-08-01178212610.7860/JCDR/2023/63808.18307Efficacy of Celecoxib and Diclofenac Sodium in the Management of Postoperative Pain, Swelling and Mouth Opening after Surgical Removal of Impacted Third Molars: A Split-mouth Randomised Clinical StudyGaurav Kumar Jha0Rajesh Ashok Kshirsagar1Vikram Singh2Sudhir Ramlal Pawar3Vivek Nair4Daksh Manish Kedia5Ojas Desai6Saurabh Jain7Postgraduate, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth DU Dental College and Hospital, Pune, Maharashtra, IndiaProfessor and Head, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth DU Dental College and Hospital, Pune, Maharashtra, India.Associate Professor, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth DU Dental College and Hospital, Pune, Maharashtra, India.Associate Professor, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth DU Dental College and Hospital, Pune, Maharashtra, IndiaAssistant Professor, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth DU Dental College and Hospital, Pune, Maharashtra, India.Postgraduate, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth DU Dental College and Hospital, Pune, Maharashtra, India.Postgraduate, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth DU Dental College and Hospital, Pune, Maharashtra, India.Postgraduate, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth DU Dental College and Hospital, Pune, Maharashtra, India.Introduction: The surgical removal of mandibular third molars is generally followed by complaints of pain, trismus, and swelling. The duration of surgery and the reflection of a mucoperiosteal flap have been shown to affect the intensity and frequency of postoperative complaints. Pain from third molar surgery typically begins within one to three hours after surgery and ranges in intensity from moderate to severe. Numerous analgesics have been used to minimise pain and discomfort following the surgical removal of impacted third molars. Commonly used agents include ibuprofen, diclofenac sodium, paracetamol, or their combinations. Newer drugs, such as selective COX inhibitors, have not been extensively used for minor oral surgical procedures. Aim: To compare the clinical efficacy of celecoxib and diclofenac sodium on pain, swelling, and mouth opening after the surgical removal of impacted mandibular third molars. Materials and Methods: A split-mouth randomised controlled clinical trial was conducted in the Department of Oral and Maxillofacial Surgery at BharatiVidyapeeth DU Dental College and Hospital, Pune, Maharashtra, India. The study duration was six months, from August 2022 to January 2023. A total of 21 subjects (11 males and 10 females) who required surgical extraction of an impacted mandibular third molar were selected. All subjects were randomly allocated to receive one of the following treatments twice a day for five days after surgery: celecoxib 200 mg (n=11) or diclofenac sodium 75 mg (n=10). Pain scores were evaluated using the Visual Analogue Scale (VAS) on postoperative day one, two, and three. Swelling and mouth opening were evaluated on Postoperative Day (POD) two and seven. Intergroup comparison was done using Student’s t-test. Results: The mean age of the study participants was 28±1.5 years, and the mean VAS score for pain evaluation with celecoxib was 6.61, 5.38, and 5.00 on day 1 (p=0.027), 2 (p=0.972), and 3 (p=0.809), respectively. The difference in swelling values for the celecoxib group was significant, while there were no significant differences in the values of mouth opening. Conclusion: It was concluded that celecoxib 200 mg is a better analgesic and anti-inflammatory compared to diclofenac sodium 75 mg. Celecoxib was easily tolerable and comfortable for the patients. There was no significant difference in the values of mouth opening. https://jcdr.net/articles/PDF/18307/63808_CE[Ra1]_F(IS)_PF1(HB_KM_OM)_QC(SHK_SS)_PFA_NC(KM)_PN(KM).pdfnon-steroidal anti-inflammatory drugspostoperative sequalaewisdom tooth surgery |
| spellingShingle | Gaurav Kumar Jha Rajesh Ashok Kshirsagar Vikram Singh Sudhir Ramlal Pawar Vivek Nair Daksh Manish Kedia Ojas Desai Saurabh Jain Efficacy of Celecoxib and Diclofenac Sodium in the Management of Postoperative Pain, Swelling and Mouth Opening after Surgical Removal of Impacted Third Molars: A Split-mouth Randomised Clinical Study Journal of Clinical and Diagnostic Research non-steroidal anti-inflammatory drugs postoperative sequalae wisdom tooth surgery |
| title | Efficacy of Celecoxib and Diclofenac Sodium in the Management of Postoperative Pain, Swelling and Mouth Opening after Surgical Removal of Impacted Third Molars: A Split-mouth Randomised Clinical Study |
| title_full | Efficacy of Celecoxib and Diclofenac Sodium in the Management of Postoperative Pain, Swelling and Mouth Opening after Surgical Removal of Impacted Third Molars: A Split-mouth Randomised Clinical Study |
| title_fullStr | Efficacy of Celecoxib and Diclofenac Sodium in the Management of Postoperative Pain, Swelling and Mouth Opening after Surgical Removal of Impacted Third Molars: A Split-mouth Randomised Clinical Study |
| title_full_unstemmed | Efficacy of Celecoxib and Diclofenac Sodium in the Management of Postoperative Pain, Swelling and Mouth Opening after Surgical Removal of Impacted Third Molars: A Split-mouth Randomised Clinical Study |
| title_short | Efficacy of Celecoxib and Diclofenac Sodium in the Management of Postoperative Pain, Swelling and Mouth Opening after Surgical Removal of Impacted Third Molars: A Split-mouth Randomised Clinical Study |
| title_sort | efficacy of celecoxib and diclofenac sodium in the management of postoperative pain swelling and mouth opening after surgical removal of impacted third molars a split mouth randomised clinical study |
| topic | non-steroidal anti-inflammatory drugs postoperative sequalae wisdom tooth surgery |
| url | https://jcdr.net/articles/PDF/18307/63808_CE[Ra1]_F(IS)_PF1(HB_KM_OM)_QC(SHK_SS)_PFA_NC(KM)_PN(KM).pdf |
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