Network controllability of structural connectomes in the neonatal brain
Abstract White matter connectivity supports diverse cognitive demands by efficiently constraining dynamic brain activity. This efficiency can be inferred from network controllability, which represents the ease with which the brain moves between distinct mental states based on white matter connectivi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41499-w |
| _version_ | 1797558232404721664 |
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| author | Huili Sun Rongtao Jiang Wei Dai Alexander J. Dufford Stephanie Noble Marisa N. Spann Shi Gu Dustin Scheinost |
| author_facet | Huili Sun Rongtao Jiang Wei Dai Alexander J. Dufford Stephanie Noble Marisa N. Spann Shi Gu Dustin Scheinost |
| author_sort | Huili Sun |
| collection | DOAJ |
| description | Abstract White matter connectivity supports diverse cognitive demands by efficiently constraining dynamic brain activity. This efficiency can be inferred from network controllability, which represents the ease with which the brain moves between distinct mental states based on white matter connectivity. However, it remains unclear how brain networks support diverse functions at birth, a time of rapid changes in connectivity. Here, we investigate the development of network controllability during the perinatal period and the effect of preterm birth in 521 neonates. We provide evidence that elements of controllability are exhibited in the infant’s brain as early as the third trimester and develop rapidly across the perinatal period. Preterm birth disrupts the development of brain networks and altered the energy required to drive state transitions at different levels. In addition, controllability at birth is associated with cognitive ability at 18 months. Our results suggest network controllability develops rapidly during the perinatal period to support cognitive demands but could be altered by environmental impacts like preterm birth. |
| first_indexed | 2024-03-10T17:27:25Z |
| format | Article |
| id | doaj.art-69d8aa8ac4eb4e0fa2404639633ff54e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:27:25Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-69d8aa8ac4eb4e0fa2404639633ff54e2023-11-20T10:07:30ZengNature PortfolioNature Communications2041-17232023-09-0114111010.1038/s41467-023-41499-wNetwork controllability of structural connectomes in the neonatal brainHuili Sun0Rongtao Jiang1Wei Dai2Alexander J. Dufford3Stephanie Noble4Marisa N. Spann5Shi Gu6Dustin Scheinost7Department of Biomedical Engineering, Yale UniversityDepartment of Radiology & Biomedical Imaging, Yale School of MedicineDepartment of Biostatistics, Yale School of Public HealthDepartment of Psychiatry and Center for Mental Health Innovation, Oregon Health & Science UniversityDepartment of Psychology, Northeastern UniversityDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia UniversitySchool of Computer Science and Engineering, University of Electronic Science and Technology of ChinaDepartment of Biomedical Engineering, Yale UniversityAbstract White matter connectivity supports diverse cognitive demands by efficiently constraining dynamic brain activity. This efficiency can be inferred from network controllability, which represents the ease with which the brain moves between distinct mental states based on white matter connectivity. However, it remains unclear how brain networks support diverse functions at birth, a time of rapid changes in connectivity. Here, we investigate the development of network controllability during the perinatal period and the effect of preterm birth in 521 neonates. We provide evidence that elements of controllability are exhibited in the infant’s brain as early as the third trimester and develop rapidly across the perinatal period. Preterm birth disrupts the development of brain networks and altered the energy required to drive state transitions at different levels. In addition, controllability at birth is associated with cognitive ability at 18 months. Our results suggest network controllability develops rapidly during the perinatal period to support cognitive demands but could be altered by environmental impacts like preterm birth.https://doi.org/10.1038/s41467-023-41499-w |
| spellingShingle | Huili Sun Rongtao Jiang Wei Dai Alexander J. Dufford Stephanie Noble Marisa N. Spann Shi Gu Dustin Scheinost Network controllability of structural connectomes in the neonatal brain Nature Communications |
| title | Network controllability of structural connectomes in the neonatal brain |
| title_full | Network controllability of structural connectomes in the neonatal brain |
| title_fullStr | Network controllability of structural connectomes in the neonatal brain |
| title_full_unstemmed | Network controllability of structural connectomes in the neonatal brain |
| title_short | Network controllability of structural connectomes in the neonatal brain |
| title_sort | network controllability of structural connectomes in the neonatal brain |
| url | https://doi.org/10.1038/s41467-023-41499-w |
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