IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinic
Chronic rhinosinusitis with nasal polyps (CRSwNP) is considered a nasal sinus inflammatory disease that can be dominated by immune cells and cytokines. IL-10 family cytokines exert essential functions in immune responses during infection and inflammation. Recently, the understanding of the roles of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.947983/full |
| _version_ | 1828428213040185344 |
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| author | Lijia Xuan Lijia Xuan Nan Zhang Xiangdong Wang Xiangdong Wang Luo Zhang Luo Zhang Luo Zhang Claus Bachert |
| author_facet | Lijia Xuan Lijia Xuan Nan Zhang Xiangdong Wang Xiangdong Wang Luo Zhang Luo Zhang Luo Zhang Claus Bachert |
| author_sort | Lijia Xuan |
| collection | DOAJ |
| description | Chronic rhinosinusitis with nasal polyps (CRSwNP) is considered a nasal sinus inflammatory disease that can be dominated by immune cells and cytokines. IL-10 family cytokines exert essential functions in immune responses during infection and inflammation. Recently, the understanding of the roles of the IL-10 family in CRSwNP is being reconsidered. IL-10 family members are now considered complex cytokines that are capable of affecting epithelial function and involved in allergies and infections. Furthermore, the IL-10 family responds to glucocorticoid treatment, and there have been clinical trials of therapies manipulating these cytokines to remedy airway inflammatory diseases. Here, we summarize the recent progress in the understanding of IL-10 family cytokines in CRSwNP and suggest more specific strategies to exploit these cytokines for the effective treatment of CRSwNP. |
| first_indexed | 2024-12-10T17:14:05Z |
| format | Article |
| id | doaj.art-69dd0e6ff3ac414691b598eef20ec0e0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T17:14:05Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-69dd0e6ff3ac414691b598eef20ec0e02022-12-22T01:40:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.947983947983IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinicLijia Xuan0Lijia Xuan1Nan Zhang2Xiangdong Wang3Xiangdong Wang4Luo Zhang5Luo Zhang6Luo Zhang7Claus Bachert8Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, ChinaUpper Airways Research Laboratory, Ghent University, Ghent, BelgiumDepartment of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, ChinaDepartment of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, ChinaUpper Airways Research Laboratory, Ghent University, Ghent, BelgiumChronic rhinosinusitis with nasal polyps (CRSwNP) is considered a nasal sinus inflammatory disease that can be dominated by immune cells and cytokines. IL-10 family cytokines exert essential functions in immune responses during infection and inflammation. Recently, the understanding of the roles of the IL-10 family in CRSwNP is being reconsidered. IL-10 family members are now considered complex cytokines that are capable of affecting epithelial function and involved in allergies and infections. Furthermore, the IL-10 family responds to glucocorticoid treatment, and there have been clinical trials of therapies manipulating these cytokines to remedy airway inflammatory diseases. Here, we summarize the recent progress in the understanding of IL-10 family cytokines in CRSwNP and suggest more specific strategies to exploit these cytokines for the effective treatment of CRSwNP.https://www.frontiersin.org/articles/10.3389/fimmu.2022.947983/fullIL-10CRSwNPepitheliuminfectiontherapy |
| spellingShingle | Lijia Xuan Lijia Xuan Nan Zhang Xiangdong Wang Xiangdong Wang Luo Zhang Luo Zhang Luo Zhang Claus Bachert IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinic Frontiers in Immunology IL-10 CRSwNP epithelium infection therapy |
| title | IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinic |
| title_full | IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinic |
| title_fullStr | IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinic |
| title_full_unstemmed | IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinic |
| title_short | IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinic |
| title_sort | il 10 family cytokines in chronic rhinosinusitis with nasal polyps from experiments to the clinic |
| topic | IL-10 CRSwNP epithelium infection therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.947983/full |
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