Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results
IntroductionImmunoglobulin G4 (IgG4) is a member of the human immunoglobulin G (IgG) subclass, a protein involved in immunity to pathogens and the body’s resistance system. IgG4-related diseases (IgG4-RD) are intractable diseases in which IgG4 levels in the blood are elevated, causing inflammation i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1272398/full |
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| author | Aoi Koshida Shigehiro Karashima Shigehiro Karashima Kohei Ogura Yuna Miyajima Kazuhiro Ogai Ren Mizoguchi Yasuo Ikagawa Satoshi Hara Ichiro Mizushima Hiroshi Fujii Mitsuhiro Kawano Hiromasa Tsujiguchi Akinori Hara Hiroyuki Nakamura Shigefumi Okamoto Shigefumi Okamoto |
| author_facet | Aoi Koshida Shigehiro Karashima Shigehiro Karashima Kohei Ogura Yuna Miyajima Kazuhiro Ogai Ren Mizoguchi Yasuo Ikagawa Satoshi Hara Ichiro Mizushima Hiroshi Fujii Mitsuhiro Kawano Hiromasa Tsujiguchi Akinori Hara Hiroyuki Nakamura Shigefumi Okamoto Shigefumi Okamoto |
| author_sort | Aoi Koshida |
| collection | DOAJ |
| description | IntroductionImmunoglobulin G4 (IgG4) is a member of the human immunoglobulin G (IgG) subclass, a protein involved in immunity to pathogens and the body’s resistance system. IgG4-related diseases (IgG4-RD) are intractable diseases in which IgG4 levels in the blood are elevated, causing inflammation in organs such as the liver, pancreas, and salivary glands. IgG4-RD are known to be more prevalent in males than in females, but the etiology remains to be elucidated. This study was conducted to investigate the relationship between gut microbiota (GM) and serum IgG4 levels in the general population.MethodsIn this study, the relationship between IgG4 levels and GM evaluated in male and female groups of the general population using causal inference. The study included 191 men and 207 women aged 40 years or older from Shika-machi, Ishikawa. GM DNA was analyzed for the 16S rRNA gene sequence using next-generation sequencing. Participants were bifurcated into high and low IgG4 groups, depending on median serum IgG4 levels.ResultsANCOVA, Tukey’s HSD, linear discriminant analysis effect size, least absolute shrinkage and selection operator logistic regression model, and correlation analysis revealed that Anaerostipes, Lachnospiraceae, Megasphaera, and [Eubacterium] hallii group were associated with IgG4 levels in women, while Megasphaera, [Eubacterium] hallii group, Faecalibacterium, Ruminococcus.1, and Romboutsia were associated with IgG4 levels in men. Linear non-Gaussian acyclic model indicated three genera, Megasphaera, [Eubacterium] hallii group, and Anaerostipes, and showed a presumed causal association with IgG4 levels in women.DiscussionThis differential impact of the GM on IgG4 levels based on sex is a novel and intriguing finding. |
| first_indexed | 2024-03-11T18:16:11Z |
| format | Article |
| id | doaj.art-69dd751402ef4e20afefe22c05407f5a |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-11T18:16:11Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-69dd751402ef4e20afefe22c05407f5a2023-10-16T07:18:53ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-10-011310.3389/fcimb.2023.12723981272398Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination resultsAoi Koshida0Shigehiro Karashima1Shigehiro Karashima2Kohei Ogura3Yuna Miyajima4Kazuhiro Ogai5Ren Mizoguchi6Yasuo Ikagawa7Satoshi Hara8Ichiro Mizushima9Hiroshi Fujii10Mitsuhiro Kawano11Hiromasa Tsujiguchi12Akinori Hara13Hiroyuki Nakamura14Shigefumi Okamoto15Shigefumi Okamoto16Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, JapanInstitute of Liberal Arts and Science, Kanazawa University, Kanazawa, JapanDepartment of Health Promotion and Medicine of the Future, Kanazawa University, Kanazawa, JapanInstitute for Frontier Science Initiative, Kanazawa University, Kanazawa, JapanDepartment of Clinical Laboratory Science, Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, JapanDepartment of Bio-engineering Nursing, Graduate School of Nursing, Ishikawa Prefectural Nursing University, Kahoku, JapanDepartment of Health Promotion and Medicine of the Future, Kanazawa University, Kanazawa, JapanInstitute for Frontier Science Initiative, Kanazawa University, Kanazawa, JapanDepartment of Rheumatology, Kanazawa University Hospital, Kanazawa, JapanDepartment of Rheumatology, Kanazawa University Hospital, Kanazawa, JapanDepartment of Rheumatology, Kanazawa University Hospital, Kanazawa, JapanDepartment of Rheumatology, Kanazawa University Hospital, Kanazawa, JapanDepartment of Hygiene and Public Health, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, JapanDepartment of Hygiene and Public Health, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, JapanDepartment of Hygiene and Public Health, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, JapanInstitute for Frontier Science Initiative, Kanazawa University, Kanazawa, JapanDepartment of Clinical Laboratory Science, Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, JapanIntroductionImmunoglobulin G4 (IgG4) is a member of the human immunoglobulin G (IgG) subclass, a protein involved in immunity to pathogens and the body’s resistance system. IgG4-related diseases (IgG4-RD) are intractable diseases in which IgG4 levels in the blood are elevated, causing inflammation in organs such as the liver, pancreas, and salivary glands. IgG4-RD are known to be more prevalent in males than in females, but the etiology remains to be elucidated. This study was conducted to investigate the relationship between gut microbiota (GM) and serum IgG4 levels in the general population.MethodsIn this study, the relationship between IgG4 levels and GM evaluated in male and female groups of the general population using causal inference. The study included 191 men and 207 women aged 40 years or older from Shika-machi, Ishikawa. GM DNA was analyzed for the 16S rRNA gene sequence using next-generation sequencing. Participants were bifurcated into high and low IgG4 groups, depending on median serum IgG4 levels.ResultsANCOVA, Tukey’s HSD, linear discriminant analysis effect size, least absolute shrinkage and selection operator logistic regression model, and correlation analysis revealed that Anaerostipes, Lachnospiraceae, Megasphaera, and [Eubacterium] hallii group were associated with IgG4 levels in women, while Megasphaera, [Eubacterium] hallii group, Faecalibacterium, Ruminococcus.1, and Romboutsia were associated with IgG4 levels in men. Linear non-Gaussian acyclic model indicated three genera, Megasphaera, [Eubacterium] hallii group, and Anaerostipes, and showed a presumed causal association with IgG4 levels in women.DiscussionThis differential impact of the GM on IgG4 levels based on sex is a novel and intriguing finding.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1272398/fullMegasphaeraimmunoglobulin G4causal relationshipdirect linear non-Gaussian acyclic modelgut microbiotaIgG4-related disease |
| spellingShingle | Aoi Koshida Shigehiro Karashima Shigehiro Karashima Kohei Ogura Yuna Miyajima Kazuhiro Ogai Ren Mizoguchi Yasuo Ikagawa Satoshi Hara Ichiro Mizushima Hiroshi Fujii Mitsuhiro Kawano Hiromasa Tsujiguchi Akinori Hara Hiroyuki Nakamura Shigefumi Okamoto Shigefumi Okamoto Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results Frontiers in Cellular and Infection Microbiology Megasphaera immunoglobulin G4 causal relationship direct linear non-Gaussian acyclic model gut microbiota IgG4-related disease |
| title | Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results |
| title_full | Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results |
| title_fullStr | Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results |
| title_full_unstemmed | Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results |
| title_short | Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results |
| title_sort | impact of gut microbiome on serum igg4 levels in the general population shika machi super preventive health examination results |
| topic | Megasphaera immunoglobulin G4 causal relationship direct linear non-Gaussian acyclic model gut microbiota IgG4-related disease |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1272398/full |
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