Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia
Abstract The pathophysiology underlying major depressive disorder (MDD) and schizophrenia is related to endocrine system functions and includes changes in the blood levels of cortisol and insulin-like growth factor 1 (IGF-1). However, these hormones have not been investigated simultaneously in patie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28449-8 |
| _version_ | 1797945879355719680 |
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| author | Hiroshi Arinami Yuichiro Watanabe Yutaro Suzuki Misuzu Tajiri Nobuto Tsuneyama Toshiyuki Someya |
| author_facet | Hiroshi Arinami Yuichiro Watanabe Yutaro Suzuki Misuzu Tajiri Nobuto Tsuneyama Toshiyuki Someya |
| author_sort | Hiroshi Arinami |
| collection | DOAJ |
| description | Abstract The pathophysiology underlying major depressive disorder (MDD) and schizophrenia is related to endocrine system functions and includes changes in the blood levels of cortisol and insulin-like growth factor 1 (IGF-1). However, these hormones have not been investigated simultaneously in patients with MDD and schizophrenia. We investigated the differences in serum cortisol and IGF-1 levels among patients with MDD and schizophrenia and controls. We included 129 patients with MDD, 71 patients with schizophrenia, and 71 healthy volunteers. Blood tests were performed between 6:00 am and 11:00 am after fasting. Serum cortisol levels were significantly higher in patients with schizophrenia than in patients with MDD and controls. Serum cortisol levels were significantly higher in patients with MDD than in controls. Serum IGF-1 levels were higher in both patient groups than in controls, whereas there was no significant difference between patients with MDD and schizophrenia. Both cortisol and IGF-1 levels were positively correlated with the Hamilton Rating Scale for Depression score in patients with MDD, whereas cortisol level was positively correlated and IGF-1 level was negatively correlated with the Brief Psychiatric Rating Scale score in patients with schizophrenia. The differences in the level of these hormones suggest pathophysiological differences between these disorders. |
| first_indexed | 2024-04-10T21:02:07Z |
| format | Article |
| id | doaj.art-69df3b1fff6e4e4f89814cbe369f0f25 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T21:02:07Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-69df3b1fff6e4e4f89814cbe369f0f252023-01-22T12:13:49ZengNature PortfolioScientific Reports2045-23222023-01-0113111010.1038/s41598-023-28449-8Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophreniaHiroshi Arinami0Yuichiro Watanabe1Yutaro Suzuki2Misuzu Tajiri3Nobuto Tsuneyama4Toshiyuki Someya5Department of Psychiatry, Niigata University Graduate School of Medical and Dental SciencesDepartment of Psychiatry, Niigata University Graduate School of Medical and Dental SciencesDepartment of Psychiatry, Niigata University Graduate School of Medical and Dental SciencesDepartment of Psychiatry, Niigata University Graduate School of Medical and Dental SciencesDepartment of Psychiatry, Niigata University Graduate School of Medical and Dental SciencesDepartment of Psychiatry, Niigata University Graduate School of Medical and Dental SciencesAbstract The pathophysiology underlying major depressive disorder (MDD) and schizophrenia is related to endocrine system functions and includes changes in the blood levels of cortisol and insulin-like growth factor 1 (IGF-1). However, these hormones have not been investigated simultaneously in patients with MDD and schizophrenia. We investigated the differences in serum cortisol and IGF-1 levels among patients with MDD and schizophrenia and controls. We included 129 patients with MDD, 71 patients with schizophrenia, and 71 healthy volunteers. Blood tests were performed between 6:00 am and 11:00 am after fasting. Serum cortisol levels were significantly higher in patients with schizophrenia than in patients with MDD and controls. Serum cortisol levels were significantly higher in patients with MDD than in controls. Serum IGF-1 levels were higher in both patient groups than in controls, whereas there was no significant difference between patients with MDD and schizophrenia. Both cortisol and IGF-1 levels were positively correlated with the Hamilton Rating Scale for Depression score in patients with MDD, whereas cortisol level was positively correlated and IGF-1 level was negatively correlated with the Brief Psychiatric Rating Scale score in patients with schizophrenia. The differences in the level of these hormones suggest pathophysiological differences between these disorders.https://doi.org/10.1038/s41598-023-28449-8 |
| spellingShingle | Hiroshi Arinami Yuichiro Watanabe Yutaro Suzuki Misuzu Tajiri Nobuto Tsuneyama Toshiyuki Someya Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia Scientific Reports |
| title | Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia |
| title_full | Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia |
| title_fullStr | Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia |
| title_full_unstemmed | Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia |
| title_short | Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia |
| title_sort | serum cortisol and insulin like growth factor 1 levels in major depressive disorder and schizophrenia |
| url | https://doi.org/10.1038/s41598-023-28449-8 |
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