Evaluation of allylestrenol for clinical pregnancies in patients treated with assisted reproductive techniques: a retrospective, propensity score matched, observational study
Abstract Background Allylestrenol is an oral progestogen being increasingly used for luteal phase support in assisted reproductive techniques. However, evidence of the clinical efficacy of allylestrenol in luteal phase support is lacking. Dydrogesterone is a representative drug used for luteal phase...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-023-05970-2 |
| _version_ | 1797451123445989376 |
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| author | Yuexin Yu Tingting Yu Weiping Ding Yinling Xiu Mengsi Zhao Kaixuan Sun Qian Zhang Xiaohang Xu |
| author_facet | Yuexin Yu Tingting Yu Weiping Ding Yinling Xiu Mengsi Zhao Kaixuan Sun Qian Zhang Xiaohang Xu |
| author_sort | Yuexin Yu |
| collection | DOAJ |
| description | Abstract Background Allylestrenol is an oral progestogen being increasingly used for luteal phase support in assisted reproductive techniques. However, evidence of the clinical efficacy of allylestrenol in luteal phase support is lacking. Dydrogesterone is a representative drug used for luteal phase support, the efficacy of which has been clinically confirmed. As such, we aimed to compare the effects of allylestrenol with the standard dydrogesterone on clinical pregnancy rates and pregnancy outcomes. Methods This retrospective study included 3375 assisted reproductive technique cycles using either allylestrenol or dydrogesterone between January 2015 and March 2020. Patients using either allylestrenol or dydrogesterone were matched in a 1:1 ratio using propensity scores. The primary outcomes were clinical pregnancy rate and pregnancy outcomes. Results No significant difference was found in the clinical pregnancy rate (53.5% vs. 53.2%, P = 0.928) and pregnancy outcomes (all P > 0.05) between allylestrenol and dydrogesterone. Compared with dydrogesterone, the use of allylestrenol significantly reduced the rate of biochemical pregnancies (6.4% vs. 11.8%, P < 0.001) and multiple gestation rate (16.8% vs. 26.3%, P = 0.001). Moreover, endometrial thickness, morphology, and blood flow were significantly improved by allylestrenol treatment (all P < 0.05). Conclusions Allylestrenol exhibited similar effects on clinical pregnancy rates and pregnancy outcomes as dydrogesterone. Moreover, allylestrenol can significantly reduce the biochemical pregnancy rate and improve the endometrial receptivity. |
| first_indexed | 2024-03-09T14:50:22Z |
| format | Article |
| id | doaj.art-69e047561ae041d187cdf3309f1a19d1 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-09T14:50:22Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-69e047561ae041d187cdf3309f1a19d12023-11-26T14:30:43ZengBMCBMC Pregnancy and Childbirth1471-23932023-09-012311810.1186/s12884-023-05970-2Evaluation of allylestrenol for clinical pregnancies in patients treated with assisted reproductive techniques: a retrospective, propensity score matched, observational studyYuexin Yu0Tingting Yu1Weiping Ding2Yinling Xiu3Mengsi Zhao4Kaixuan Sun5Qian Zhang6Xiaohang Xu7Department of Reproductive Medicine, General Hospital of Northern Theater CommandDepartment of Reproductive Medicine, General Hospital of Northern Theater CommandObstetrics and gynecology clinic of the 79th Army Group HospitalDepartment of Reproductive Medicine, General Hospital of Northern Theater CommandDepartment of Reproductive Medicine, General Hospital of Northern Theater CommandDepartment of Reproductive Medicine, General Hospital of Northern Theater CommandDepartment of Reproductive Medicine, General Hospital of Northern Theater CommandDepartment of Reproductive Medicine, General Hospital of Northern Theater CommandAbstract Background Allylestrenol is an oral progestogen being increasingly used for luteal phase support in assisted reproductive techniques. However, evidence of the clinical efficacy of allylestrenol in luteal phase support is lacking. Dydrogesterone is a representative drug used for luteal phase support, the efficacy of which has been clinically confirmed. As such, we aimed to compare the effects of allylestrenol with the standard dydrogesterone on clinical pregnancy rates and pregnancy outcomes. Methods This retrospective study included 3375 assisted reproductive technique cycles using either allylestrenol or dydrogesterone between January 2015 and March 2020. Patients using either allylestrenol or dydrogesterone were matched in a 1:1 ratio using propensity scores. The primary outcomes were clinical pregnancy rate and pregnancy outcomes. Results No significant difference was found in the clinical pregnancy rate (53.5% vs. 53.2%, P = 0.928) and pregnancy outcomes (all P > 0.05) between allylestrenol and dydrogesterone. Compared with dydrogesterone, the use of allylestrenol significantly reduced the rate of biochemical pregnancies (6.4% vs. 11.8%, P < 0.001) and multiple gestation rate (16.8% vs. 26.3%, P = 0.001). Moreover, endometrial thickness, morphology, and blood flow were significantly improved by allylestrenol treatment (all P < 0.05). Conclusions Allylestrenol exhibited similar effects on clinical pregnancy rates and pregnancy outcomes as dydrogesterone. Moreover, allylestrenol can significantly reduce the biochemical pregnancy rate and improve the endometrial receptivity.https://doi.org/10.1186/s12884-023-05970-2AllylestrenolDydrogesteroneAssisted reproductive techniquesLuteal phase supportProgesterone |
| spellingShingle | Yuexin Yu Tingting Yu Weiping Ding Yinling Xiu Mengsi Zhao Kaixuan Sun Qian Zhang Xiaohang Xu Evaluation of allylestrenol for clinical pregnancies in patients treated with assisted reproductive techniques: a retrospective, propensity score matched, observational study BMC Pregnancy and Childbirth Allylestrenol Dydrogesterone Assisted reproductive techniques Luteal phase support Progesterone |
| title | Evaluation of allylestrenol for clinical pregnancies in patients treated with assisted reproductive techniques: a retrospective, propensity score matched, observational study |
| title_full | Evaluation of allylestrenol for clinical pregnancies in patients treated with assisted reproductive techniques: a retrospective, propensity score matched, observational study |
| title_fullStr | Evaluation of allylestrenol for clinical pregnancies in patients treated with assisted reproductive techniques: a retrospective, propensity score matched, observational study |
| title_full_unstemmed | Evaluation of allylestrenol for clinical pregnancies in patients treated with assisted reproductive techniques: a retrospective, propensity score matched, observational study |
| title_short | Evaluation of allylestrenol for clinical pregnancies in patients treated with assisted reproductive techniques: a retrospective, propensity score matched, observational study |
| title_sort | evaluation of allylestrenol for clinical pregnancies in patients treated with assisted reproductive techniques a retrospective propensity score matched observational study |
| topic | Allylestrenol Dydrogesterone Assisted reproductive techniques Luteal phase support Progesterone |
| url | https://doi.org/10.1186/s12884-023-05970-2 |
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