Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats
The beneficial immunomodulation effects of a biological response modifier glucan (BRMG) produced by two strains of Aureobasidium pullulans, AFO-202 and N-163, have already been reported. Herein, we compared their efficacy on immune-inflammatory parameters in Sprague Dawley (SD) rats. This study was...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Clinical Immunology Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772613421000081 |
| _version_ | 1811297818460028928 |
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| author | Nobunao Ikewaki Kadalraja Raghavan Vidyasagar Devaprasad Dedeepiya Suryaprakash Vaddi Masaru Iwasaki Rajappa Senthilkumar Senthilkumar Preethy Samuel JK Abraham |
| author_facet | Nobunao Ikewaki Kadalraja Raghavan Vidyasagar Devaprasad Dedeepiya Suryaprakash Vaddi Masaru Iwasaki Rajappa Senthilkumar Senthilkumar Preethy Samuel JK Abraham |
| author_sort | Nobunao Ikewaki |
| collection | DOAJ |
| description | The beneficial immunomodulation effects of a biological response modifier glucan (BRMG) produced by two strains of Aureobasidium pullulans, AFO-202 and N-163, have already been reported. Herein, we compared their efficacy on immune-inflammatory parameters in Sprague Dawley (SD) rats. This study was performed on four groups of healthy SD rats, n=6 in each group: Group 1, euthanised on Day 0 for baseline values; Group 2, control (drinking water); Group 3, AFO-202 beta glucan, 200 mg/kg/day; and Group 4, N-163 beta glucan, 300 mg/kg/day. The neutrophil to lymphocyte ratio (NLR) decreased and leukocyte-to C-reactive protein ratio (LeCR) increased in Group 3 (AFO-202) at 15 and 29 days whereas the lymphocyte to C-reactive protein ratio (LCR) increased in group 4 (N-163), within the normal physiological range. These promising results warrant further investigations in larger numbers of healthy and diseased models to develop appropriate strategies for balancing immune system dysregulation. |
| first_indexed | 2024-04-13T06:10:47Z |
| format | Article |
| id | doaj.art-69e105b6050f4bdda3ec62937fa195d2 |
| institution | Directory Open Access Journal |
| issn | 2772-6134 |
| language | English |
| last_indexed | 2024-04-13T06:10:47Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Immunology Communications |
| spelling | doaj.art-69e105b6050f4bdda3ec62937fa195d22022-12-22T02:59:05ZengElsevierClinical Immunology Communications2772-61342021-12-0112934Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley ratsNobunao Ikewaki0Kadalraja Raghavan1Vidyasagar Devaprasad Dedeepiya2Suryaprakash Vaddi3Masaru Iwasaki4Rajappa Senthilkumar5Senthilkumar Preethy6Samuel JK Abraham7Dept. of Medical Life Science, Kyushu University of Health and Welfare, Japan; Institute of Immunology, Junsei Educational Institute, Nobeoka, Miyazaki, JapanResearch & Development Division, Sarvee Integra Private Limited, Chennai, India.; Dept. of Paediatric Neurology, Jesuit Antonyraj memorial Inter-disciplinary Centre for Advanced Rehabilitation and Education (JAICARE), Madurai, IndiaMary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, IndiaDepartment of Urology, Yashoda Hospitals, Hyderabad, IndiaCentre for Advancing Clinical Research (CACR), University of Yamanashi - School of Medicine, Chuo, Japan.Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, IndiaFujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, IndiaMary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, India; Centre for Advancing Clinical Research (CACR), University of Yamanashi - School of Medicine, Chuo, Japan.; Antony- Xavier Interdisciplinary Scholastics (AXIS), GN Corporation Co. Ltd., Kofu, Japan; Corresponding Author: Dr. Samuel JK Abraham, University of Yamanashi, School of Medicine, Chuo, Japan, 3-8, Wakamatsu, Kofu, Yamanashi 400-0866, Japan, Phone: +81-55-235-7527The beneficial immunomodulation effects of a biological response modifier glucan (BRMG) produced by two strains of Aureobasidium pullulans, AFO-202 and N-163, have already been reported. Herein, we compared their efficacy on immune-inflammatory parameters in Sprague Dawley (SD) rats. This study was performed on four groups of healthy SD rats, n=6 in each group: Group 1, euthanised on Day 0 for baseline values; Group 2, control (drinking water); Group 3, AFO-202 beta glucan, 200 mg/kg/day; and Group 4, N-163 beta glucan, 300 mg/kg/day. The neutrophil to lymphocyte ratio (NLR) decreased and leukocyte-to C-reactive protein ratio (LeCR) increased in Group 3 (AFO-202) at 15 and 29 days whereas the lymphocyte to C-reactive protein ratio (LCR) increased in group 4 (N-163), within the normal physiological range. These promising results warrant further investigations in larger numbers of healthy and diseased models to develop appropriate strategies for balancing immune system dysregulation.http://www.sciencedirect.com/science/article/pii/S2772613421000081Beta glucansAureobasidium pullulansAFO-202N-163neutrophil to lymphocyte ratio (NLR)lymphocyte to c-reactive protein ratio (LCR), leucocyte to c-reactive protein ratio (LeCR) |
| spellingShingle | Nobunao Ikewaki Kadalraja Raghavan Vidyasagar Devaprasad Dedeepiya Suryaprakash Vaddi Masaru Iwasaki Rajappa Senthilkumar Senthilkumar Preethy Samuel JK Abraham Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats Clinical Immunology Communications Beta glucans Aureobasidium pullulans AFO-202 N-163 neutrophil to lymphocyte ratio (NLR) lymphocyte to c-reactive protein ratio (LCR), leucocyte to c-reactive protein ratio (LeCR) |
| title | Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats |
| title_full | Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats |
| title_fullStr | Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats |
| title_full_unstemmed | Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats |
| title_short | Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats |
| title_sort | beneficial immune regulatory effects of novel strains of aureobasidium pullulans afo 202 and n 163 produced beta glucans in sprague dawley rats |
| topic | Beta glucans Aureobasidium pullulans AFO-202 N-163 neutrophil to lymphocyte ratio (NLR) lymphocyte to c-reactive protein ratio (LCR), leucocyte to c-reactive protein ratio (LeCR) |
| url | http://www.sciencedirect.com/science/article/pii/S2772613421000081 |
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