Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome
Post-viral fatigue syndrome (PVFS) is a widespread chronic neurological disease with no definite etiological factor(s), no actual diagnostic test, and no approved pharmacological treatment, therapy, or cure. Among other features, PVFS could be accompanied by various irregularities in creatine metabo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/2/503 |
| _version_ | 1797415474262179840 |
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| author | Sergej M. Ostojic |
| author_facet | Sergej M. Ostojic |
| author_sort | Sergej M. Ostojic |
| collection | DOAJ |
| description | Post-viral fatigue syndrome (PVFS) is a widespread chronic neurological disease with no definite etiological factor(s), no actual diagnostic test, and no approved pharmacological treatment, therapy, or cure. Among other features, PVFS could be accompanied by various irregularities in creatine metabolism, perturbing either tissue levels of creatine in the brain, the rates of phosphocreatine resynthesis in the skeletal muscle, or the concentrations of the enzyme creatine kinase in the blood. Furthermore, supplemental creatine and related guanidino compounds appear to impact both patient- and clinician-reported outcomes in syndromes and maladies with chronic fatigue. This paper critically overviews the most common disturbances in creatine metabolism in various PVFS populations, summarizes human trials on dietary creatine and creatine analogs in the syndrome, and discusses new frontiers and open questions for using creatine in a post-COVID-19 world. |
| first_indexed | 2024-03-09T05:48:08Z |
| format | Article |
| id | doaj.art-69e28af822c2459aaa10fc00559303a1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T05:48:08Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-69e28af822c2459aaa10fc00559303a12023-12-03T12:19:15ZengMDPI AGNutrients2072-66432021-02-0113250310.3390/nu13020503Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue SyndromeSergej M. Ostojic0FSPE Applied Bioenergetics Lab, University of Novi Sad, 21000 Novi Sad, SerbiaPost-viral fatigue syndrome (PVFS) is a widespread chronic neurological disease with no definite etiological factor(s), no actual diagnostic test, and no approved pharmacological treatment, therapy, or cure. Among other features, PVFS could be accompanied by various irregularities in creatine metabolism, perturbing either tissue levels of creatine in the brain, the rates of phosphocreatine resynthesis in the skeletal muscle, or the concentrations of the enzyme creatine kinase in the blood. Furthermore, supplemental creatine and related guanidino compounds appear to impact both patient- and clinician-reported outcomes in syndromes and maladies with chronic fatigue. This paper critically overviews the most common disturbances in creatine metabolism in various PVFS populations, summarizes human trials on dietary creatine and creatine analogs in the syndrome, and discusses new frontiers and open questions for using creatine in a post-COVID-19 world.https://www.mdpi.com/2072-6643/13/2/503post-viral fatigue syndromechronic fatigue syndromecreatineGAAcreatine kinase |
| spellingShingle | Sergej M. Ostojic Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome Nutrients post-viral fatigue syndrome chronic fatigue syndrome creatine GAA creatine kinase |
| title | Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome |
| title_full | Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome |
| title_fullStr | Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome |
| title_full_unstemmed | Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome |
| title_short | Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome |
| title_sort | diagnostic and pharmacological potency of creatine in post viral fatigue syndrome |
| topic | post-viral fatigue syndrome chronic fatigue syndrome creatine GAA creatine kinase |
| url | https://www.mdpi.com/2072-6643/13/2/503 |
| work_keys_str_mv | AT sergejmostojic diagnosticandpharmacologicalpotencyofcreatineinpostviralfatiguesyndrome |